文献

J-GLOBAL ID：202202281073440111   整理番号：22A1178063

全身性硬化症における非コードRNAの役割【JST・京大機械翻訳】

The Roles of Noncoding RNAs in Systemic Sclerosis

著者 (15件)： Liu Yongmei (1Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China) ,  Liu Yongmei (2State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China) ,  Cheng Linlin (1Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China) ,  Cheng Linlin (2State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China) ,  Zhan Haoting (1Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China) ,  Zhan Haoting (2State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China) ,  Li Haolong (1Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China) ,  Li Haolong (2State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China) ,  Li Xiaomeng (1Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China) ,  Li Xiaomeng (2State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China) ,  Li Xiaomeng (3Department of Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China) ,  Huang Yuan (1Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China) ,  Huang Yuan (2State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China) ,  Li Yongzhe (1Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China) ,  Li Yongzhe (2State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China)
資料名： Frontiers in Immunology (Web)  (Frontiers in Immunology (Web))
巻： 13  ページ： 856036  発行年： 2022年 
JST資料番号： U7074A  ISSN： 1664-3224  資料種別： 逐次刊行物 (A)
記事区分： 文献レビュー  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 非コードRNA(ncRNA)は,ヒトゲノムにおけるRNAの90%以上を構成する。過去数十年間,研究は,染色体修飾,mRNAスプライシングおよび安定性および翻訳,ならびに重要なシグナル伝達経路を含む重要な過程を仲介する「junk」転写産物から機能的調節分子へのncRNAの著者らの認識を変化させた。新たな証拠は,ncRNAが癌だけでなく,全身性硬化症(SSc)のような自己免疫疾患でも異常に発現し,SScの診断および治療のための新規バイオマーカーおよび治療標的として役立つ可能性があることを示唆する。しかし,SScにおけるncRNAの機能および基礎となる機構は,不完全に理解されている。本レビューでは,マイクロRNAおよび長い非コードRNAを含むncRNAの生体遺伝学的過程および機能に関する現在の知見,ならびにSScに対する新生ncRNAに基づく診断および治療法を探索することを論じた。Copyright 2022 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 調整 ,  *RNA【核酸】 ,  染色体 ,  可能性 ,  ゲノム ,  遺伝学 ,  治療法 ,  自己免疫病 ,  アンチセンスRNA ,  バイオマーカー
準シソーラス用語： マイクロRNA ,  *非翻訳RNA ,  ヒトゲノム ,  全身性強皮症 ,  転写産物 ,  伝達経路 ,  治療標的 , 【Automatic Indexing@JST】

著者キーワード (6件)： ncRNA ,  miRNA ,  lncRNA ,  全身性硬化症 ,  機能 ,  バイオマーカー

分類 (2件)： 遺伝子発現  (EC02040Q) ,  分子遺伝学一般  (EC02010J)

引用文献 (122件)：

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タイトルに関連する用語 (3件)： 全身性硬化症 ,  非コードRNA ,  役割