文献

J-GLOBAL ID：202202282053261388   整理番号：22A1107252

集中治療室に入院したCOVID-19患者における中間用量対標準用量予防的抗凝固療法: INSPIRATION無作為化試験からの90日の結果【JST・京大機械翻訳】

Intermediate-Dose versus Standard-Dose Prophylactic Anticoagulation in Patients with COVID-19 Admitted to the Intensive Care Unit: 90-Day Results from the INSPIRATION Randomized Trial

著者 (77件)： Rashidi Farid ( Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran) ,  Bakhshandeh Hooman ( Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran) ,  Bakhshandeh Hooman ( Department of Anesthesiology, School of Medicine Anesthesiology Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Rafiee Farnaz ( Department of Anesthesiology, School of Medicine Anesthesiology Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Rezaeifar Parisa ( Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran) ,  Baghizadeh Elahe ( Department of Anesthesiology, School of Medicine Anesthesiology Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Matin Samira ( Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran) ,  Jamalkhani Sepehr ( Department of Internal Medicine, School of Medicine, Shariati Hospital, Tehran, Iran) ,  Tahamtan Ouria ( Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran) ,  Sharif-Kashani Babak ( Department of Pharmacotherapy, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran) ,  Sharif-Kashani Babak ( Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran) ,  Beigmohammadi Mohammad Taghi ( Chronic Respiratory Disease Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Farrokhpour Mohsen ( Yale/YNHH Center for Outcomes Research and Evaluation, New Haven, Connecticut, United States) ,  Sezavar Seyed Hashem ( Department of Pharmacotherapy, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran) ,  Payandemehr Pooya ( School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran) ,  Dabbagh Ali ( Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran) ,  Moghadam Keivan Gohari ( Department of Pulmonary and Critical Care, School of Medicine, Shariati Hospital, Tehran, Iran) ,  Khalili Hossein ( Advanced Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran) ,  Yadollahzadeh Mahdi ( Yale/YNHH Center for Outcomes Research and Evaluation, New Haven, Connecticut, United States) ,  Riahi Taghi ( Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Abedini Atefeh ( Shahid Dr. Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Lookzadeh Somayeh ( Shahid Dr. Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Rahmani Hamid ( College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, United States) ,  Zoghi Elnaz ( Respiratory Department, Hospital Ramon y Cajal, Madrid, Spain) ,  Mohammadi Keyhan ( Respiratory Department, Hospital Ramon y Cajal, Madrid, Spain) ,  Sadeghipour Pardis ( Yale/YNHH Center for Outcomes Research and Evaluation, New Haven, Connecticut, United States) ,  Abri Homa ( Yale/YNHH Center for Outcomes Research and Evaluation, New Haven, Connecticut, United States) ,  Tabrizi Sanaz ( Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Mousavian Seyed Masoud ( Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Shahmirzaei Shaghayegh ( School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran) ,  Amin Ahmad ( Department of Anesthesiology, School of Medicine Anesthesiology Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Mohebbi Bahram ( Medicine Department, Universidad de Alcala, Madrid, Spain) ,  Parhizgar Seyed Ehsan ( Department of Anesthesiology, School of Medicine Anesthesiology Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Aliannejad Rasoul ( Cardiovascular Research Foundation, New York, New York, United States) ,  Aliannejad Rasoul ( CIBER Enfermedades Respiratorias, Madrid, Spain) ,  Eslami Vahid ( Division of Cardiology, Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York, New York, United States) ,  Kashefizadeh Alireza ( Department of Internal Medicine, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain) ,  Dobesh Paul P. ( Universidad Catolica de Murcia, Murcia, Spain) ,  Kakavand Hessam ( Respiratory Department, Hospital Ramon y Cajal, Madrid, Spain) ,  Hosseini Seyed Hossein ( Respiratory Department, Hospital Ramon y Cajal, Madrid, Spain) ,  Shafaghi Shadi ( Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran) ,  Ghazi Samrand Fattah ( Chronic Respiratory Disease Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Najafi Atabak ( School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran) ,  Jimenez David ( Department of Pharmacotherapy and Outcome Science, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, United States) ,  Jimenez David ( Division of Cardiology, Department of Internal Medicine, Pauley Heart Center, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, United States) ,  Jimenez David ( The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States) ,  Gupta Aakriti ( Department of Cardiology, Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Gupta Aakriti ( Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran) ,  Gupta Aakriti ( Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom) ,  Madhavan Mahesh V. ( Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran) ,  Madhavan Mahesh V. ( Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom) ,  Sethi Sanjum S. ( Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran) ,  Sethi Sanjum S. ( Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom) ,  Parikh Sahil A. ( Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran) ,  Parikh Sahil A. ( Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom) ,  Monreal Manuel ( Aalborg University, Aalborg, Denmark) ,  Monreal Manuel ( Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States) ,  Hadavand Naser ( Department of Anesthesiology, School of Medicine Anesthesiology Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Hajighasemi Alireza ( Department of Internal Medicine, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran) ,  Maleki Majid ( Department of Anesthesiology, School of Medicine Anesthesiology Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Sadeghian Saeed ( Department of Internal Medicine, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran) ,  Piazza Gregory ( Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States) ,  Kirtane Ajay J. ( Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran) ,  Kirtane Ajay J. ( Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom) ,  Van Tassell Benjamin W. ( Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran) ,  Van Tassell Benjamin W. ( Department of Health Policy and Administration, Yale School of Public Health, New Haven, Connecticut, United States) ,  Stone Gregg W. ( Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran) ,  Stone Gregg W. ( Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran) ,  Lip Gregory Y. H. ( Clinical Trial Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran) ,  Lip Gregory Y. H. ( Rajaie Cardiovascular Medical and Research Center, Iran university of Medical Sciences, Tehran, Iran) ,  Krumholz Harlan M. ( Department of Cardiology, Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Krumholz Harlan M. ( Student Research Committee, Iran University of Medical Sciences, Tehran, Iran) ,  Krumholz Harlan M. ( Tobacoo Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Goldhaber Samuel Z. ( Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States) ,  Sadeghipour Parham ( Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran) ,  Sadeghipour Parham ( Department of Anesthesiology, School of Medicine Anesthesiology Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran) ,  Sadeghipour Parham ( Respiratory Department, Hospital Ramon y Cajal, Madrid, Spain)
資料名： Thrombosis and Haemostasis  (Thrombosis and Haemostasis)
巻： 122  号： 01  ページ： 131-141  発行年： 2022年 
JST資料番号： T0298A  ISSN： 0340-6245  CODEN： THHADQ  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 背景:血栓性合併症は,コロナウイルス疾患2019(COVID-19)の主な肺外症状の間で考えられている。これらの患者における予防的抗血栓療法の最適型と期間は,不明のままである。【方法】:本論文は,COVID-19:An opeNラベルランダム化比較試験(INSPIRATION)研究による,中間対標準用量のプロフィラクチック抗凝固薬(cRitical-ill pATIents)の最終(90日)結果を報告する。集中治療に入院したCOVID-19患者を,病院退院状態に関係なく,30日間,中間用量対標準用量予防抗凝固に対して無作為化した。一次有効性転帰は,アジュバント静脈または動脈血栓症,体外膜酸素化(ECMO)による治療,または全死因死亡の複合体であった。主な安全性転帰は,主要な出血であった。結果:600人の無作為化患者のうち,562人は修正意図-治療分析(年齢中央値[Q1,Q3]:62[50,71]歳;237[42.2%]女性)に入り,そのうち336人(59.8%)は退院に生存した。一次転帰は,中間用量に割り当てられた患者132名(47.8%)および標準用量予防抗凝固薬(ハザード比[HR]:1.21,95%信頼区間[CI]:0.95~1.55,p=0.11)に割り当てられた130名(45.4%)の患者で発生した。所見は,他の有効性転帰,および31日から90日(HR:1.59,95%CI:0.45-5.06)までのランドマーク分析において類似していた。中用量群(3致死事象を含む)および4(1.4%)主要出血イベントの7(2.5%)大出血イベントが,標準用量群(非致死的)(HR:1.82,95%CI:0.53~6.24)にあった。結論:標準用量予防的抗凝固と比較した中用量は,90日の追跡調査で,死亡,ECMOによる治療,または静脈または動脈血栓症の複合体を減少させなかった。Please refer to the publisher for the copyright holders. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *凝固 ,  血栓症 ,  抗凝固薬 ,  死 ,  出血 ,  静脈 ,  薬物療法 ,  複合体 ,  *用量 ,  合併症 ,  死因 ,  ランダム化比較試験 ,  *抗凝固療法
準シソーラス用語： *集中治療 ,  大量出血 ,  抗血栓療法 ,  *COVID-19 , 【Automatic Indexing@JST】

著者キーワード (5件)： 抗凝固療法 ,  ヘパリン ,  エノキサパリン ,  COVID-19 ,  試験

分類 (4件)： 循環系疾患の薬物療法  (GJ05020M) ,  循環系の疾患  (GJ03000C) ,  血液・体液作用薬の臨床への応用  (GW14020X) ,  呼吸器の疾患  (GI03000Z)

タイトルに関連する用語 (7件)： 集中治療室 ,  入院 ,  患者 ,  用量 ,  標準 ,  予防的抗凝固療法 ,  無作為化試験