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J-GLOBAL ID：202202285115743415   整理番号：22A0569013

ヨーロッパ,アフリカおよびアジアの祖先の女性の子宮腫瘍におけるペプチド祖先の有益なマーカー【JST・京大機械翻訳】

Peptide ancestry informative markers in uterine neoplasms from women of European, African, and Asian ancestry

著者 (51件)： Bateman Nicholas W. (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Bateman Nicholas W. (The John P. Murtha Cancer Center, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Bateman Nicholas W. (Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Dr., Suite 100, Bethesda, MD 20817, USA) ,  Tarney Christopher M. (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Abulez Tamara S. (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Abulez Tamara S. (Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Dr., Suite 100, Bethesda, MD 20817, USA) ,  Hood Brian L. (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Hood Brian L. (Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Dr., Suite 100, Bethesda, MD 20817, USA) ,  Conrads Kelly A. (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Conrads Kelly A. (Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Dr., Suite 100, Bethesda, MD 20817, USA) ,  Zhou Ming (Department of Obstetrics and Gynecology, Inova Fairfax Medical Campus, 3300 Gallows Road, Falls Church, VA 22042, USA) ,  Soltis Anthony R. (Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Dr., Suite 100, Bethesda, MD 20817, USA) ,  Soltis Anthony R. (The American Genome Center; Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA) ,  Teng Pang-Ning (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Teng Pang-Ning (Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Dr., Suite 100, Bethesda, MD 20817, USA) ,  Jackson Amanda (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Tian Chunqiao (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Tian Chunqiao (Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Dr., Suite 100, Bethesda, MD 20817, USA) ,  Dalgard Clifton L. (The American Genome Center; Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA) ,  Dalgard Clifton L. (Department of Anatomy Physiology and Genetics, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA) ,  Wilkerson Matthew D. (The John P. Murtha Cancer Center, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Wilkerson Matthew D. (Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Dr., Suite 100, Bethesda, MD 20817, USA) ,  Wilkerson Matthew D. (The American Genome Center; Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA) ,  Wilkerson Matthew D. (Department of Anatomy Physiology and Genetics, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA) ,  Kessler Michael D. (Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA) ,  Goecker Zachary (University of California, Davis, One Shields Avenue, Davis, CA 95616, USA) ,  Loffredo Jeremy (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Shriver Craig D. (The John P. Murtha Cancer Center, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Hu Hai (The John P. Murtha Cancer Center, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Hu Hai (Chan Soon-Shiong Institute of Molecular Medicine at Windber, Windber, PA 15963, USA) ,  Cote Michele (Wayne State University, Detroit, MI 48202, USA) ,  Parker Glendon J. (University of California, Davis, One Shields Avenue, Davis, CA 95616, USA) ,  Segars James (Johns Hopkins University Medical Center, Baltimore, MD 21218, USA) ,  Al-Hendy Ayman (The University of Illinois College of Medicine, Chicago, IL 60612, USA) ,  Risinger John I. (Department of Obstetrics and Gynecology, Michigan State University, East Lansing, MI 48824, USA) ,  Phippen Neil T. (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Phippen Neil T. (The John P. Murtha Cancer Center, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Casablanca Yovanni (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Casablanca Yovanni (The John P. Murtha Cancer Center, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Darcy Kathleen M. (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Darcy Kathleen M. (The John P. Murtha Cancer Center, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Darcy Kathleen M. (Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Dr., Suite 100, Bethesda, MD 20817, USA) ,  Maxwell G. Larry (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Maxwell G. Larry (The John P. Murtha Cancer Center, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Maxwell G. Larry (Department of Obstetrics and Gynecology, Inova Fairfax Medical Campus, 3300 Gallows Road, Falls Church, VA 22042, USA) ,  Conrads Thomas P. (Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Conrads Thomas P. (The John P. Murtha Cancer Center, Uniformed Services University and Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA) ,  Conrads Thomas P. (Department of Obstetrics and Gynecology, Inova Fairfax Medical Campus, 3300 Gallows Road, Falls Church, VA 22042, USA) ,  O’Connor Timothy D. (Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA) ,  O’Connor Timothy D. (Program in Personalize and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA) ,  O’Connor Timothy D. (Marlene and Stewart Greenebaum Comprehensive Cancer, University of Maryland School of Medicine, Baltimore, MD 21201, USA)
資料名： iScience  (iScience)
巻： 25  号： 1  ページ： Null  発行年： 2022年 
JST資料番号： W5512A  ISSN： 2589-0042  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 疾患関連患者組織における祖先結合ペプチド変異体の特性化は,患者祖先を疾患病因と結びつける基礎段階である。ペプチド祖先情報マーカー(pAIM)と呼ばれる,ヨーロッパ,アフリカおよび東アジア人集団における高い対立遺伝子頻度を示すトリプシンペプチド内のミスセンス置換をコードする非同義単一ヌクレオチド多型を1000ゲノムから優先した。in silico分析は,20pAIMsが>260K SNP(R2=0.99)と同様に祖先比率を決定できることを確認した。>100のヒト子宮内膜癌細胞系および子宮平滑筋腫組織の多重プロテオーム分析は,患者人種および遺伝子型確認祖先と相関する62のpAIMsの定量をもたらした。Candidatesはアフリカとヨーロッパの集団におけるビタミンDレベルの変化に以前に関連するGCビタミンD結合蛋白質におけるD451E置換を含み,pAIMsは,ヒトプロテオームに対する祖先の影響,およびこれが子宮新生物の病因とどのように関連するかを調査する努力と同様に,全般的なプロテオーム評価を支持する。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *ペプチド ,  遺伝子型 ,  *子宮 ,  *腫瘍 ,  ビタミンD ,  ヒト ,  ゲノム ,  多重化 ,  遺伝子頻度 ,  子宮内膜癌 ,  病因 ,  プロテオミクス ,  一塩基多型 ,  プロテオーム
準シソーラス用語： in silico , 【Automatic Indexing@JST】

著者キーワード (4件)： ゲノミクス ,  精密医学 ,  プロテオミクス ,  プロテオゲノミクス

分類 (1件)： 集団遺伝学  (EC01040J)

タイトルに関連する用語 (7件)： ヨーロッパ ,  アフリカ ,  アジア ,  女性 ,  子宮腫瘍 ,  ペプチド ,  マーカー