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J-GLOBAL ID：202202285764959812   整理番号：22A0775374

METTL16は,翻訳と腫瘍形成を促進するためにm=6A非依存性機能を発揮する【JST・京大機械翻訳】

METTL16 exerts an m⁶A-independent function to facilitate translation and tumorigenesis

著者 (48件)： Su Rui (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Dong Lei (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Li Yangchan (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Li Yangchan (Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China) ,  Gao Min (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Gao Min (Department of Pharmaceutics, School of Pharmaceutical Science, Jiangnan University, Wuxi, China) ,  He P. Cody (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA) ,  He P. Cody (Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA) ,  Liu Wei (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Liu Wei (Department of Immunology, Hebei Medical University, Shijiazhuang, China) ,  Wei Jiangbo (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA) ,  Wei Jiangbo (Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA) ,  Zhao Zhicong (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Zhao Zhicong (Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China) ,  Gao Lei (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Han Li (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Han Li (School of Pharmacy, China Medical University, Shenyang, China) ,  Deng Xiaolan (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Li Chenying (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Li Chenying (Key Laboratory of Hematopoietic Malignancies, The First Affiliated Hospital of Zhejiang University, Hangzhou, China) ,  Prince Emily (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Tan Brandon (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Qing Ying (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Qin Xi (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Shen Chao (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Xue Meilin (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Zhou Keren (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Chen Zhenhua (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Xue Jianhuang (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Li Wei (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Qin Hanjun (The Integrative Genomics Core, Beckman Research Institute of City of Hope, Duarte, CA, USA) ,  Wu Xiwei (The Integrative Genomics Core, Beckman Research Institute of City of Hope, Duarte, CA, USA) ,  Sun Miao (Keck School of Medicine, University of Southern California, and Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Los Angeles, CA, USA) ,  Nam Yunsun (Laboratory of RNA Biology, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA) ,  Chen Chun-Wei (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Chen Chun-Wei (City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA) ,  Huang Wendong (Department of Diabetes Complications and Metabolism, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, USA) ,  Huang Wendong (Graduate School of Biological Science, City of Hope, Duarte, CA, USA) ,  Horne David (City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA) ,  Horne David (Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA, USA) ,  Rosen Steven T. (City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA) ,  Rosen Steven T. (Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA) ,  Rosen Steven T. (Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA) ,  He Chuan (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA) ,  He Chuan (Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA) ,  Chen Jianjun (Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA) ,  Chen Jianjun (City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA) ,  Chen Jianjun (Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA)
資料名： Nature Cell Biology  (Nature Cell Biology)
巻： 24  号： 2  ページ： 205-216  発行年： 2022年 
JST資料番号： W1369A  ISSN： 1465-7392  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： METTL16は,いくつかの転写産物におけるN6-メチルアデノシン(m6A)の沈着に関与するRNAメチルトランスフェラーゼとして最近同定されている。METTL16はMETTL3とMETTL14と類似の転写産物の大きなセットをメチル化するかどうかは不明である。ここに,METTL16は遺伝子調節においてメチルトランスフェラーゼ活性依存性及び非依存性機能の両方を発揮することを示した。細胞核において,METTL16はm6Aの書き込みとして機能し,m6Aを数百のその特異的メッセンジャーRNA標的に沈着させる。サイトゾルにおいて,METTL16はm6A非依存性様式で翻訳を促進する。より具体的には,METTL16は,真核生物開始因子3aおよび-bならびにリボソームRNAと,そのMターゼドメインを介し直接相互作用し,翻訳開始複合体の集合を促進し,4,000以上のmRNA転写物の翻訳を促進する。さらに,METTL16が肝細胞癌の腫瘍形成に重要であることを示した。まとめると,著者らの研究は,m6Aの書き込み者としてMETTL16の以前に非承認された二重機能および翻訳開始促進因子を明らかにし,腫瘍形成における必須機能に寄与する。Suらは,METTL16が核においてm6Aの書き込みとして作用する一方で,リボソームRNAと真核生物開始因子3aおよび-bとの直接相互作用を介して翻訳を促進するサイトゾルにおいてm6A非依存性機能を発揮することを報告する。Copyright The Author(s), under exclusive licence to Springer Nature Limited 2022 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 相互作用 ,  メチル化 ,  RNA【核酸】 ,  mRNA ,  rRNA ,  細胞核 ,  転写【遺伝】 ,  メチルトランスフェラーゼ ,  遺伝的調節 ,  サイトゾル ,  プロモーター領域 ,  RNAメチルトランスフェラーゼ ,  沈着 ,  *腫瘤形成
準シソーラス用語： 転写産物 ,  翻訳開始 , 【Automatic Indexing@JST】

分類 (2件)： 遺伝子発現  (EC02040Q) ,  生物学的機能  (EB03040U)

タイトルに関連する用語 (4件)： 翻訳 ,  腫瘍形成 ,  促進 ,  非依存性