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J-GLOBAL ID：202202285945629577   整理番号：22A0567914

尿のプロテオミクスおよびメタボロミクスプロファイリングはCOVID-19患者における免疫応答を明らかにする【JST・京大機械翻訳】

Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19

著者 (53件)： Bi Xiaojie (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Liu Wei (Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China) ,  Liu Wei (Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China) ,  Liu Wei (Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China) ,  Liu Wei (Westlake Omics (Hangzhou) Biotechnology, Hangzhou 310024, China) ,  Ding Xuan (Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China) ,  Ding Xuan (Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China) ,  Ding Xuan (Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China) ,  Liang Shuang (Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China) ,  Liang Shuang (Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China) ,  Liang Shuang (Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China) ,  Zheng Yufen (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Zhu Xiaoli (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Quan Sheng (Calibra Lab at DIAN Diagnostics, 329 Jinpeng Street, Hangzhou 310030, Zhejiang Province, China) ,  Yi Xiao (Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China) ,  Yi Xiao (Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China) ,  Yi Xiao (Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China) ,  Yi Xiao (Westlake Omics (Hangzhou) Biotechnology, Hangzhou 310024, China) ,  Xiang Nan (Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China) ,  Xiang Nan (Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China) ,  Xiang Nan (Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China) ,  Xiang Nan (Westlake Omics (Hangzhou) Biotechnology, Hangzhou 310024, China) ,  Du Juping (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Lyu Haiyan (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Yu Die (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Zhang Chao (Calibra Lab at DIAN Diagnostics, 329 Jinpeng Street, Hangzhou 310030, Zhejiang Province, China) ,  Xu Luang (Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China) ,  Xu Luang (Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China) ,  Xu Luang (Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China) ,  Ge Weigang (Westlake Omics (Hangzhou) Biotechnology, Hangzhou 310024, China) ,  Zhan Xinke (Westlake Omics (Hangzhou) Biotechnology, Hangzhou 310024, China) ,  He Jiale (Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China) ,  He Jiale (Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China) ,  He Jiale (Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China) ,  Xiong Zi (Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China) ,  Zhang Shun (Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China) ,  Li Yanchang (State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Institute of Lifeomics, Beijing, 102206, China) ,  Xu Ping (State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Institute of Lifeomics, Beijing, 102206, China) ,  Zhu Guangjun (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Wang Donglian (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Zhu Hongguo (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Chen Shiyong (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Li Jun (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Zhao Haihong (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Zhu Yi (Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China) ,  Zhu Yi (Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China) ,  Zhu Yi (Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China) ,  Liu Huafen (Calibra Lab at DIAN Diagnostics, 329 Jinpeng Street, Hangzhou 310030, Zhejiang Province, China) ,  Xu Jiaqin (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Shen Bo (Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang, China) ,  Guo Tiannan (Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China) ,  Guo Tiannan (Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China) ,  Guo Tiannan (Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China)
資料名： Cell Reports  (Cell Reports)
巻： 38  号： 3  ページ： Null  発行年： 2022年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 感染症における尿プロテオームの有用性は不明である。ここでは,COVID-19患者と健常対照者の尿と血清試料のプロテオームとメタボロームを分析した。著者らのデータは,尿蛋白質が重度によってCOVID-19を効果的に分類することを示した。尿中で197のサイトカインとその受容体を検出したが,TMTに基づくプロテオミクスを用いて血清で124のみを検出した。尿中ESCRT複合体蛋白質の減少は活性SARS-CoV-2複製と相関した。重度のCOVID-19症例における尿中CXCL14のダウンレギュレーションは,血液リンパ球数と正に相関した。統合マルチミクス分析は,先天性免疫活性化と炎症がCOVID-19患者において腎損傷を誘発することを示唆する。尿プロテオームのCOVID-19関連調節は,この疾患の病因へのユニークな洞察を提供する。本研究は,COVID-19の免疫病理生物学と臨床経過,および潜在的に他の感染症を評価する際に,一連のマルチオミクス検体における尿プロテオームを含む付加価値を示した。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *解析 ,  炎症 ,  血清 ,  受容体 ,  タンパク質 ,  感染症 ,  病状経過 ,  ダウンレギュレーション ,  サイトカイン ,  タンパク質複合体 ,  病因 ,  *プロテオミクス ,  自然免疫 ,  プロテオーム
準シソーラス用語： *メタボロミクス ,  尿蛋白質 ,  メタボローム , 【Automatic Indexing@JST】

著者キーワード (8件)： COVID-19 ,  プロテオミクス ,  メタボロミクス ,  血清 ,  尿 ,  CXCL14 ,  ESCRT超複合体 ,  腎臓損傷

分類 (2件)： 蛋白質・ペプチド一般  (EB03010N) ,  代謝異常・栄養性疾患一般  (GD05010J)

タイトルに関連する用語 (4件)： 尿 ,  プロテオミクス ,  患者 ,  免疫応答