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J-GLOBAL ID：202202286319601477   整理番号：22A0295876

最近の脳卒中と心房細動の最古高齢者における経口抗凝固薬【JST・京大機械翻訳】

Oral Anticoagulants in the Oldest Old with Recent Stroke and Atrial Fibrillation

著者 (51件)： Polymeris Alexandros A. (Department of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Polymeris Alexandros A. (Neurology and Neurorehabilitation, University Hospital for Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland) ,  Macha Kosmas (Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany) ,  Paciaroni Maurizio (Neurology - Stroke Unit, IRCCS MultiMedica, Milan, Italy) ,  Wilson Duncan (Stroke Research Center, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK) ,  Wilson Duncan (New Zealand Brain Research Institute, Christchurch, New Zealand) ,  Koga Masatoshi (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan) ,  Cappellari Manuel (Stroke Unit - Department of Neuroscience, Azienda Ospedaliera Universitaria Integrata, Verona, Italy) ,  Schaedelin Sabine (Clinical Trial Unit, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Zietz Annaelle (Department of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Peters Nils (Department of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Peters Nils (Neurology and Neurorehabilitation, University Hospital for Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland) ,  Peters Nils (Stroke Center, Klinik Hirslanden, Zurich, Switzerland) ,  Seiffge David J. (Stroke Research Center, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK) ,  Seiffge David J. (Department of Neurology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland) ,  Haupenthal David (Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany) ,  Gassmann Luise (Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany) ,  De Marchis Gian Marco (Department of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Wang Ruihao (Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany) ,  Gensicke Henrik (Department of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Gensicke Henrik (Neurology and Neurorehabilitation, University Hospital for Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland) ,  Stoll Svenja (Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany) ,  Thilemann Sebastian (Department of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Avramiotis Nikolaos S. (Department of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Bonetti Bruno (Stroke Unit - Department of Neuroscience, Azienda Ospedaliera Universitaria Integrata, Verona, Italy) ,  Tsivgoulis Georgios (Second Department of Neurology, Attikon University Hospital, National & Kapodistrian University of Athens, Athens, Greece) ,  Tsivgoulis Georgios (Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA) ,  Ambler Gareth (Department of Statistical Science, University College London, London, UK) ,  Alberti Andrea (Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy) ,  Yoshimura Sohei (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan) ,  Brown Martin M. (Stroke Research Center, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK) ,  Shiozawa Masayuki (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan) ,  Lip Gregory Y. H. (Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK) ,  Lip Gregory Y. H. (Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark) ,  Venti Michele (Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy) ,  Acciarresi Monica (Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy) ,  Tanaka Kanta (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan) ,  Mosconi Maria Giulia (Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy) ,  Takagi Masahito (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan) ,  Jaeger Rolf H. (Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK) ,  Muir Keith (Institute of Neuroscience & Psychology, University of Glasgow and Queen Elizabeth University Hospital, Glasgow, UK) ,  Inoue Manabu (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan) ,  Schwab Stefan (Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany) ,  Bonati Leo H. (Department of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Lyrer Philippe A. (Department of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Toyoda Kazunori (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan) ,  Caso Valeria (Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy) ,  Werring David J. (Stroke Research Center, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK) ,  Kallmuenzer Bernd (Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany) ,  Engelter Stefan T. (Department of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland) ,  Engelter Stefan T. (Neurology and Neurorehabilitation, University Hospital for Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland)
資料名： Annals of Neurology  (Annals of Neurology)
巻： 91  号： 1  ページ： 78-88  発行年： 2022年 
JST資料番号： T0008A  ISSN： 0364-5134  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 目的:85歳以上の心房細動(AF)患者における最近の脳卒中後のビタミンK拮抗薬(VKA)に対する直接経口抗凝固薬(DOAC)の安全性と有効性を調査すること。方法:7つの前向き脳卒中コホートからの個々の患者データ解析。AFと最近の脳卒中(<3か月)の患者のDOAC対VKA治療を≧85歳から<85歳まで比較した。一次転帰は,再発性脳卒中,頭蓋内出血(ICH)および全死因死亡の複合体であった。交絡因子を説明するために,単純,調整および加重Cox回帰を用いた。重み付きICHリスクに対する脳卒中低減のバランスにより,DOAC対VKAの正味利益を計算した。結果:全体で,6,267(95.5%)の患者の5,984は,分析に適格であった。それらの内,1380(23%)は≧85歳で,3,688(62%)はDOACを受けた。6,874人の患者年の追跡調査の間,複合転帰の危険に対する抗凝固剤型(DOAC対VKA)の影響は,≧85歳(HR≧85y=0.65,95%CI[0.52,0.81])と<85歳(HR_<85y=0.79,95%CI[0.66,0.95])の患者で,単純(p_相互作用=0.129),調整(p_相互作用=0.094)または加重(p_相互作用=0.512)モデルで差はなかった。再発脳卒中,ICHおよび死亡に関する分析は,90歳で二分化した年齢および連続変数としての感度解析と同様に,一次分析と一致した。DOACは,≧85歳(+1.73~+2.66)および<85歳(ICH体重1.5~3.1)の患者で,同様の正味の臨床的利点を有した。結論:AFと最近の脳卒中の患者におけるVKA上のDOACの好ましいプロフィールは,最も古い高齢者で維持された。ANN NEUROL 2022;91:78-88。Copyright 2022 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 相互作用 ,  リスク ,  *抗凝固薬 ,  死 ,  *心房細動 ,  複合体 ,  患者 ,  *脳卒中 ,  頭蓋内出血 ,  治療法 ,  母集団 ,  再発 ,  死因
準シソーラス用語： *経口抗凝固薬 ,  NOAC , 【Automatic Indexing@JST】

分類 (4件)： 血液・体液作用薬の臨床への応用  (GW14020X) ,  神経系の疾患  (GN03000O) ,  循環系疾患の治療一般  (GJ05010B) ,  循環系疾患の薬物療法  (GJ05020M)

タイトルに関連する用語 (4件)： 脳卒中 ,  心房細動 ,  高齢者 ,  経口抗凝固薬