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J-GLOBAL ID：202202287704135321   整理番号：22A0965010

ヒト組織におけるSARS-CoV-2RNAの細胞下検出は肺胞2型肺細胞および肺胞マクロファージにおける明確な局在を明らかにする【JST・京大機械翻訳】

Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages

著者 (25件)： Acheampong Kofi K. (Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Schaff Dylan L. (Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Emert Benjamin L. (Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Lake Jonathan (Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Reffsin Sam (Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Shea Emily K. (Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Comar Courtney E. (Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Comar Courtney E. (Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Comar Courtney E. (Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Philadelphia, Pennsylvania, USA) ,  Comar Courtney E. (Clinical Microbiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Comar Courtney E. (Infectious Disease Diagnostics Laboratory, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA) ,  Litzky Leslie A. (Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Khurram Nigar A. (Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Khurram Nigar A. (Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA) ,  Linn Rebecca L. (Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Linn Rebecca L. (Division of Anatomic Pathology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA) ,  Feldman Michael (Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Weiss Susan R. (Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Weiss Susan R. (Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Philadelphia, Pennsylvania, USA) ,  Montone Kathleen T. (Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Cherry Sara (Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Cherry Sara (Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Philadelphia, Pennsylvania, USA) ,  Cherry Sara (Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Shaffer Sydney M. (Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA) ,  Shaffer Sydney M. (Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania, USA)
資料名： mBio  (mBio)
巻： 13  号： 1  ページ： Null  発行年： 2022年 
JST資料番号： W5746A  ISSN： 2150-7511  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： ここでは,SARS-CoV-2ウイルスにより生成されたRNAに対するin situ RNA検出アッセイを開発した。著者らは,COVID患者の病理学標本からの肺,リンパ節,および胎盤サンプルにおけるウイルスRNAを発見した。高倍率顕微鏡を用いて,単一細胞におけるこれらのRNAの細胞内分布を可視化できる。Please refer to the publisher for the copyright holders. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *RNA【核酸】 ,  胎盤 ,  *肺胞 ,  ヒト ,  リンパ節 ,  可視化 ,  細胞内分布 ,  *肺胞マクロファージ
準シソーラス用語： *SARSウイルス ,  ウイルスRNA ,  単一細胞 , 【Automatic Indexing@JST】

分類 (1件)： ウイルス感染の生理と病原性  (EG04042Y)

タイトルに関連する用語 (6件)： ヒト ,  組織 ,  細胞 ,  肺胞 ,  肺 ,  肺胞マクロファージ