文献

J-GLOBAL ID：202202288515707534   整理番号：22A0064716

既存のポリメラーゼ特異的T細胞が血清陰性のSARS-CoV-2不稔感染で増加する

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

著者 (120件)： SWADLING Leo (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  DINIZ Mariana O. (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  SCHMIDT Nathalie M. (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  AMIN Oliver E. (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  CHANDRAN Aneesh (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  SHAW Emily (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  JEFFERY-SMITH Anna (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  KUCYKOWICZ Stephanie (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  AIDOO-MICAH Gloryanne (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  ROSENHEIM Joshua (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  DAVIES Jessica (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  MCCOY Laura E. (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  CHAIN Benjamin M. (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  HINGORANI Aroon D. (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  NOURSADEGHI Mahdad (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  NOURSADEGHI Mahdad (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  MAINI Mala K. (Div. of Infection and Immunity, Univ. Coll. London, London, GBR) ,  PADE Corinna (Blizard Inst., Barts and the London School of Medicine and Dentistry, Queen Mary Univ. London, London, GBR) ,  GIBBONS Joseph M. (Blizard Inst., Barts and the London School of Medicine and Dentistry, Queen Mary Univ. London, London, GBR) ,  JEFFERY-SMITH Anna (Blizard Inst., Barts and the London School of Medicine and Dentistry, Queen Mary Univ. London, London, GBR) ,  BULLOCK Natalie (Blizard Inst., Barts and the London School of Medicine and Dentistry, Queen Mary Univ. London, London, GBR) ,  LEE Wing-Yiu Jason (Blizard Inst., Barts and the London School of Medicine and Dentistry, Queen Mary Univ. London, London, GBR) ,  JONES Meleri (Blizard Inst., Barts and the London School of Medicine and Dentistry, Queen Mary Univ. London, London, GBR) ,  MCKNIGHT Aine (Blizard Inst., Barts and the London School of Medicine and Dentistry, Queen Mary Univ. London, London, GBR) ,  MCKNIGHT Aine (Blizard Inst., Barts and the London School of Medicine and Dentistry, Queen Mary Univ. London, London, GBR) ,  LE BERT Nina (Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, SGP) ,  TAN Anthony T. (Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, SGP) ,  THAM Christine Y. L. (Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, SGP) ,  BERTOLETTI Antonio (Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, SGP) ,  TAN Cedric C. S. (UCL Genetics Inst., Univ. Coll. London, London, GBR) ,  VAN DORP Lucy (UCL Genetics Inst., Univ. Coll. London, London, GBR) ,  BALLOUX Francois (UCL Genetics Inst., Univ. Coll. London, London, GBR) ,  JOHNSON Marina (Great Ormond Street Inst. of Child Health NIHR Biomedical Res. Centre, Univ. Coll. London, London, GBR) ,  GOLDBLATT David (Great Ormond Street Inst. of Child Health NIHR Biomedical Res. Centre, Univ. Coll. London, London, GBR) ,  JENSEN Melanie P. (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  JOY George (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  MANISTY Charlotte (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  TREIBEL Thomas A. (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  MOON James C. (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  ABBASS Hakam (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  ABIODUN Aderonke (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  ALFARIH Mashael (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  ALLDIS Zoe (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  ANDIAPEN Mervyn (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  ARTICO Jessica (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  AUGUSTO Joao B. (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  BACA Georgina L. (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  BHUVA Anish N. (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  BOULTER Alex (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  BOWLES Ruth (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  O’BRIEN Ben (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  CHAMPION Nicola (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  CHAN Carmen (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  DE SOUSA Jorge Couto (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  COUTO-PARADA Xose (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  CUTINO-MOGUE Teresa (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  DAVIES Rhodri H. (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  DIEOBI-ANENE Keenan (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  FINLAY Malcolm (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  FOROOGHI Nasim (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  HAMBLIN Matt (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  HUGHES Gemma (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  HUGHES Rebecca (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  ITUA Ivie (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  JARDIM Victor (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  JENSEN Melanie Petra (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  JOY George (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  KAPIL Vikas (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  KURDI Hibba (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  LAMBOURNE Jonathan (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  MANDADAPU Vineela (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  MENACHO Katia (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  MFUKO Celina (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  MITCHELMORE Oliver (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  PALMA Susana (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  PATEL Kush (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  PETERSEN Steffen E. (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  PINIERA Brian (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  POPE Daniel (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  PROSSORA Mary (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  RICHARDS Amy (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  SAMBILE Genine (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  SERAPHIM Andreas (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  THORNTON George D. (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  TUCKER Art (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  VEERAPEN Jessry (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  VIJAYAKUMAR Mohit (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  WELCH Sophie (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  WODEHOUSE Theresa (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  WYNNE Lucinda (Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London, GBR) ,  JENSEN Melanie P. (Dep. of Cellular Pathology, Northwest London Pathology, Imperial Coll. London NHS Trust, London, GBR) ,  JENSEN Melanie Petra (Dep. of Cellular Pathology, Northwest London Pathology, Imperial Coll. London NHS Trust, London, GBR) ,  JOY George (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  MANISTY Charlotte (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  TREIBEL Thomas A. (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  MOON James C. (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  ABIODUN Aderonke (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  CAPTUR Gabriella (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  HOWES Lee (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  HUGHES Alun (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  HUGHES Rebecca (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  JOY George (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  KURDI Hibba (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  RAPALA Alicja (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  THORNTON George D. (Inst. of Cardiovascular Sci., Univ. Coll. London, London, GBR) ,  VALDES Ana M. (Academic Rheumatology, Clinical Sci., Nottingham City Hospital, Nottingham, GBR) ,  VALDES Ana M. (NIHR Nottingham Biomedical Res. Centre, Nottingham Univ. Hospitals NHS Trust and Univ. Nottingham, Nottingham, GBR) ,  ALTMANN Daniel M. (Dep. of Immunology and Inflammation, Imperial Coll. London, London, GBR) ,  BOYTON Rosemary J. (Dep. of Infectious Disease, Fac. of Medicine, Imperial Coll. London, London, GBR) ,  BAILEY Sasha N. L. (Dep. of Infectious Disease, Fac. of Medicine, Imperial Coll. London, London, GBR) ,  BOYTON Rosemary J. (Dep. of Infectious Disease, Fac. of Medicine, Imperial Coll. London, London, GBR) ,  BUTLER David K. (Dep. of Infectious Disease, Fac. of Medicine, Imperial Coll. London, London, GBR) ,  LIN Kai-Min (Dep. of Infectious Disease, Fac. of Medicine, Imperial Coll. London, London, GBR) ,  MUNOZ-SANDOVAL Diana (Dep. of Infectious Disease, Fac. of Medicine, Imperial Coll. London, London, GBR) ,  MURRAY Sam M. (Dep. of Infectious Disease, Fac. of Medicine, Imperial Coll. London, London, GBR) ,  PIEPER Franziska P. (Dep. of Infectious Disease, Fac. of Medicine, Imperial Coll. London, London, GBR) ,  REYNOLDS Catherine J. (Dep. of Infectious Disease, Fac. of Medicine, Imperial Coll. London, London, GBR) ,  BOYTON Rosemary J. (Lung Div., Royal Brompton & Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, GBR) ,  BOYTON Rosemary J. (Lung Div., Royal Brompton & Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, GBR) ,  FEEHAN Karen (Singapore Immunology Network, A*STAR, Singapore, SGP)
資料名： Nature (London)  (Nature (London))
巻： 601  号： 7891  ページ： 110-117  発行年： 2022年01月06日 
JST資料番号： D0193B  ISSN： 0028-0836  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 重症急性呼吸器症候群コロナウイルス2(SARS-CoV-2)に曝露された可能性のある人が,必ずしもPCR陽性や抗体陽性になるわけではない。これは,一部の人ではセロコンバージョン前に不顕性感染が消失する可能性を示唆している。T細胞は,SARS-CoV-2をはじめとするコロナウイルスの感染の迅速な除去に寄与することができる。今回我々は,SARS-CoV-2に対する交差防御能を有する既存の記憶T細胞応答がin vivoで増大し,急速なウイルス抑制を促して不稔感染を誘導するという仮説を立てた。我々は,PCR検査,抗体結合検査,中和抗体検査で繰り返し陰性[血清陰性HCW(SN-HCW)]と判定された,集中的にモニタリングを受けた医療従事者において,SARS-CoV-2反応性T細胞[初期に転写された複製-転写複合体(RTC)に対するものを含む]を測定した。SN-HCWは,パンデミック以前の曝露歴のない人の集団(パンデミック前コホート)と比較して,より強力で多特異的な記憶T細胞を持ち,これらの細胞は,対応付けされた同時的コホートで検出可能な感染後に見られる構造タンパク質が支配的な反応よりも,RTCに対してより頻繁に反応した。最も強力なRTC特異的T細胞を持つSN-HCWでは,SARS-CoV-2のロバストな初期自然免疫シグネチャーであるIFI27が上昇しており,これは不稔感染を示唆する。RTC内のRNAポリメラーゼは,ヒト季節性コロナウイルス(HCoV)やSARS-CoV-2クレードを通じて,高い配列保存性を示す最も大きな領域であった。RNAポリメラーゼは,パンデミック前コホートやSN-HCW由来のT細胞によって(調べた領域の中では)優先的に標的化されていた。SN-HCWでは,HCoV変異株を交差認識するRTCエピトープ特異的なT細胞が見つかった。濃縮されたすでに多く存在するRNAポリメラーゼ特異的T細胞は,顕性のSARS-CoV-2感染と比較して不稔感染だと推定されるSARS-CoV-2感染の後,in vivoで拡大し,記憶応答で優先的に蓄積した。我々のデータは,RTC特異的なT細胞が,エンデミックおよびコロナウイルス科(Coronaviridae)のウイルス科の新興ウイルスに対するワクチンの標的であることを示している。Copyright Nature Japan KK 2022

シソーラス用語： RNAポリメラーゼ ,  *血清 ,  抗体 ,  ヒト ,  ワクチン ,  *T細胞 ,  母集団 ,  *不発感染 ,  エピトープ ,  ターゲティング ,  潜伏感染 ,  中和抗体 ,  自然免疫
準シソーラス用語： コロナウイルス ,  メモリーT細胞 , 【Automatic Indexing@JST】

分類 (2件)： 感染免疫  (ED03030P) ,  ウイルス感染の生理と病原性  (EG04042Y)

タイトルに関連する用語 (4件)： T細胞 ,  血清 ,  SARS-CoV-2 ,  不稔感染