文献

J-GLOBAL ID：202202288592008412   整理番号：22A0431551

汎癌調査における優性腫瘍免疫原型の発見【JST・京大機械翻訳】

Discovering dominant tumor immune archetypes in a pan-cancer census

著者 (110件)： Combes Alexis J. (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Combes Alexis J. (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Combes Alexis J. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Combes Alexis J. (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Samad Bushra (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Samad Bushra (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Samad Bushra (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Samad Bushra (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Tsui Jessica (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Tsui Jessica (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Tsui Jessica (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Tsui Jessica (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Chew Nayvin W. (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Chew Nayvin W. (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Chew Nayvin W. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Chew Nayvin W. (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Yan Peter (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Yan Peter (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Yan Peter (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Yan Peter (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Reeder Gabriella C. (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Reeder Gabriella C. (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Reeder Gabriella C. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Reeder Gabriella C. (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Kushnoor Divyashree (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Kushnoor Divyashree (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Kushnoor Divyashree (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Kushnoor Divyashree (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Shen Alan (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Shen Alan (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Shen Alan (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Shen Alan (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Davidson Brittany (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Davidson Brittany (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Davidson Brittany (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Barczak Andrea J. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Barczak Andrea J. (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Adkisson Michael (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Adkisson Michael (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Edwards Austin (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Edwards Austin (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Edwards Austin (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Edwards Austin (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Naser Mohammad (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Naser Mohammad (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Naser Mohammad (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Naser Mohammad (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Barry Kevin C. (Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA) ,  Courau Tristan (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Courau Tristan (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Courau Tristan (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Courau Tristan (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Hammoudi Taymour (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Hammoudi Taymour (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Hammoudi Taymour (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Hammoudi Taymour (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Argueello Rafael J. (Aix Marseille University, CNRS, INSERM, CIML, Centre d’Immunologie de Marseille-Luminy, Marseille, France) ,  Rao Arjun Arkal (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Rao Arjun Arkal (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Rao Arjun Arkal (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Rao Arjun Arkal (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Olshen Adam B. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Olshen Adam B. (Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Olshen Adam B. (Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Cai Cathy (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Cai Cathy (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Cai Cathy (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Cai Cathy (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Zhan Jenny (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Zhan Jenny (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Zhan Jenny (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Zhan Jenny (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Davis Katelyn C. (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Davis Katelyn C. (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Davis Katelyn C. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Davis Katelyn C. (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Kelley Robin K. (Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Chapman Jocelyn S. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Chapman Jocelyn S. (Departments of Obstetrics, Gynecology, and Reproductive Sciences, Medicine, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Atreya Chloe E. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Atreya Chloe E. (Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Atreya Chloe E. (Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Patel Amar (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Patel Amar (Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Daud Adil I. (Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Daud Adil I. (Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Ha Patrick (Department of Otolaryngology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Diaz Aaron A. (Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Kratz Johannes R. (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Kratz Johannes R. (Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Collisson Eric A. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Collisson Eric A. (Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Collisson Eric A. (Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Fragiadakis Gabriela K. (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Fragiadakis Gabriela K. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Fragiadakis Gabriela K. (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Fragiadakis Gabriela K. (Department of Medicine Division of Rheumatology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Erle David J. (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Erle David J. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Erle David J. (UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Erle David J. (Lung Biology Center, Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Boissonnas Alexandre (Sorbonne Universite, INSERM, CNRS, Centre d’Immunologie et des Maladies Infectieuses-CIMI, Paris, France) ,  Asthana Saurabh (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Asthana Saurabh (Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Chan Vincent (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Chan Vincent (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Chan Vincent (Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Krummel Matthew F. (Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Krummel Matthew F. (ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Krummel Matthew F. (UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 185  号： 1  ページ： 184-203.e19  発行年： 2022年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 癌は,起源の組織,ドライバー変異および周囲の組織の他の特徴に関して有意な不均一性を示す。個々の腫瘍は,免疫システム-here”原型”-創造的非破壊腫瘍免疫微小環境(TMEs)の共通パターンおよび腫瘍標的化の調節に共通する。優勢な免疫系弓型を発見するため,California,サンフランシスコ(UCSF)免疫プロファイルイニシアティブ(IPI)の大学は,標準化プロトコルを用いて12の癌タイプにわたって364の個々の腫瘍を加工した。細胞サブコンパートメントから得たフローサイトメトリーおよびトランスクリプトームデータのコンピュータクラスタリングは,癌にわたる免疫組成の優勢なパターンを明らかにした。これらの弓型は,ユニークな免疫および腫瘍遺伝子発現パターンに基づいて腫瘍を分化するので,重大なinsofarであった。また,それらは腫瘍生物学の十分に確立された分類を分割した。IPI資源は,免疫組織の主要なパターンの収集として癌免疫を理解するためのテンプレートを提供し,治療を改善するためにこれらをどのように調節するかを学ぶための合理的な経路を提供する。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 標準化 ,  *腫瘍 ,  *優性 ,  不均一性 ,  フローサイトメトリー ,  *腫瘍免疫 ,  トランスクリプトーム
準シソーラス用語： 免疫系 ,  微小環境 ,  腫瘍標的 ,  遺伝子発現パターン ,  癌生物学 , 【Automatic Indexing@JST】

著者キーワード (6件)： 汎癌分析 ,  腫瘍免疫学 ,  固形腫瘍微小環境 ,  免疫プロファイリング ,  システム免疫学 ,  教師なしクラスタリング

分類 (5件)： 発癌機序・因子  (GE02020C) ,  腫ようの化学・生化学・病理学  (GE02030N) ,  免疫反応一般  (ED03010T) ,  細胞生理一般  (EF02010S) ,  遺伝子発現  (EC02040Q)

タイトルに関連する用語 (5件)： 癌 ,  調査 ,  腫瘍免疫 ,  原型 ,  発見