文献

J-GLOBAL ID：202202289784982826   整理番号：22A0650687

アペリンは変形性関節症におけるMeniscus内皮細胞アポトーシスを軽減する【JST・京大機械翻訳】

Apelin Alleviates Meniscus Endothelial Cell Apoptosis in Osteoarthritis

著者 (31件)： Lu Dinggui (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Lu Dinggui (Department of Traumatology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Wei Jihua (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Wei Jihua (Department of Traumatology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Wei Jihua (Department of Sport Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Chen Jian (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Chen Jian (Department of Spinal Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Zhao Jingjie (Life Science and Clinical Research Center, The Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi Province, China) ,  Wang Jiajia (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Gong Yuanxun (Life Science and Clinical Research Center, The Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi Province, China) ,  Wei Liuzhi (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Wei Liuzhi (School of Pharmacy, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Wei Qiuju (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Wei Qiuju (School of Pharmacy, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Ban Huadeng (Department of Foot and Hand Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Li Yueyong (Department of Interventive Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Wang Zechen (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Luo Changtai (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Luo Changtai (Department of Traumatology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Luo Changtai (Department of Sport Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Zhou Haidong (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Zhou Haidong (Department of Traumatology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Zhou Haidong (Department of Sport Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Shen Jiajia (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Liao Qiujiao (Department of Spinal Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  He Siyuan (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Zhang Weiyang (Department of Traumatology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Luo Qunqiang (Department of Foot and Hand Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Xie Kegong (Department of Spinal Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Song Jian (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China) ,  Meng Lingzhang (Center for Systemic Inflammation Research (CSIR), School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi Province, China)
資料名： Disease Markers  (Disease Markers)
巻： 2022  ページ： Null  発行年： 2022年 
JST資料番号： W1784A  ISSN： 0278-0240  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 変形性関節症(OA)は関節軟骨および/または軟骨細胞破壊を特徴とする変性疾患であり,それは長い間一次疾患と考えられてきたが,軟骨下微小環境における半月板内皮細胞調節の重要性は最近注目されている。以前の研究はアペリンが潜在的に細胞アポトーシスを阻害することを示した。しかし,アペリンがOA半月板における内皮の保護において保護的役割を果たすかどうかは不明である。本研究では,単一細胞RNA配列決定(scRNA-seq)データの利点を用いて,フローサイトメトリーと組み合わせて,Homeobox A13(HOXA13)とRas蛋白質特異的グアニンヌクレオチド受容体(RASGRF2)の高発現を特徴とする,半月板における2つの内皮サブクラスタを同定した。対照患者と比較して,両サブクラスターは絶対細胞数で減少し,APJ内因性リガンド(APLN,アペリンをコードする)をダウンレギュレートし,アペリン受容体(APLNR,アペリン受容体をコードする)をアップレギュレートした。さらに,OAにおいて,両方のサブクラスタを含む内皮細胞数の減少は,内因性アポトーシス因子,すなわちカスパーゼ3(CASP3)に関連する1つおよびBH3-相互作用ドメインDeathアゴニスト(BID)と関連することを確認した。患者から精製した半月板内皮細胞のin vitro培養は,アペリンが内皮細胞サブクラスターのこれら2つの因子のダウンレギュレーションによりアポトーシスを有意に阻害でき,アペリンがOA患者の治療標的として潜在的に機能することを示した。Copyright 2022 Dinggui Lu et al. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 相互作用 ,  RNA【核酸】 ,  受容体 ,  クラスタ ,  *変形性関節症 ,  フローサイトメトリー ,  *内皮 ,  *内皮細胞 ,  ダウンレギュレーション ,  in vitro実験 ,  *アポトーシス ,  軟骨細胞 ,  カスパーゼ ,  半月板
準シソーラス用語： カスパーゼ3 ,  治療標的 , 【Automatic Indexing@JST】

分類 (2件)： 運動器系の基礎医学  (GG01020B) ,  運動器系の疾患  (GG03000T)

引用文献 (43件)：

• P. Ghosh, P. A. Cheras, "Vascular mechanisms in osteoarthritis," Best Practice & Research. Clinical Rheumatology, vol. 15, pp. 693-709, 2001.
• S. M. Hussain, C. Dawson, Y. Wang, A. M. Tonkin, L. Chou, A. E. Wluka, F. M. Cicuttini, "Vascular pathology and osteoarthritis: a systematic review," The Journal of Rheumatology, vol. 47, pp. 748-760, 2020.
• W. Hu, Y. Chen, C. Dou, S. Dong, "Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis," Annals of the Rheumatic Diseases, vol. 80, pp. 413-422, 2021.
• S. Nebelung, L. Dötsch, D. Shah, D. B. Abrar, K. Linka, M. Knobe, P. Sewerin, J. Thüring, C. Kuhl, D. Truhn, "Functional MRI mapping of human meniscus functionality and its relation to degeneration," Scientific Reports, vol. 10, no. 1, pp. 2499, 2020.
• D. M. Findlay, "Vascular pathology and osteoarthritis," The Journal of Rheumatology, vol. 46, no. 12, pp. 1763-1768, 2007.

タイトルに関連する用語 (4件)： アペリン ,  変形性関節症 ,  内皮細胞 ,  アポトーシス