文献

J-GLOBAL ID：202202290208891083   整理番号：22A0431524

風疹ワクチン誘導肉芽腫は細胞毒性における遺伝的欠損の不完全浸透を伴う新規表現型である【JST・京大機械翻訳】

Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity

著者 (59件)： Gross Miriam (Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Gross Miriam (Faculty of Biology, University of Freiburg, Freiburg, Germany) ,  Speckmann Carsten (Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Speckmann Carsten (Center for Pediatrics and Adolescent Medicine, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  May Annette (Institute for Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Gajardo-Carrasco Tania (Molecular Basis of Altered Immune Homeostasis Laboratory, Institut National de la Sante et de la Recherche Medicale (INSERM), Unite Mixte de Recherche (UMR) 1163, Paris, France) ,  Gajardo-Carrasco Tania (Imagine Institute, Universite de Paris, Paris, France) ,  Wustrau Katharina (Division of Pediatric Stem Cell Transplantation and Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Maier Sarah Lena (Division of Pediatric Stem Cell Transplantation and Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Panning Marcus (Institute of Virology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Huzly Daniela (Institute of Virology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Agaimy Abbas (Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuernberg, Erlangen, Germany) ,  Bryceson Yenan T. (Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden) ,  Bryceson Yenan T. (Broegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, Bergen, Norway) ,  Choo Sharon (Department of Allergy and Immunology, The Royal Children’s Hospital, Melbourne, Australia) ,  Chow C.W. (Department of Anatomical Pathology, The Royal Children’s Hospital, Melbourne, Australia) ,  Dueckers Gregor (Helios Klinikum Krefeld, Zentrum fuer Kinder- und Jugendmedizin, Krefeld, Germany) ,  Fasth Anders (Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg, Gothenburg, Sweden) ,  Fraitag Sylvie (Department of Pathology, Necker-Enfants Malades Hospital, Paris, France) ,  Graewe Katja (Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Haxelmans Sabine (Life Imaging Center, University of Freiburg, Freiburg, Germany) ,  Holzinger Dirk (Department of Pediatric Hematology-Oncology, University of Duisburg-Essen, Essen, Germany) ,  Hudowenz Ole (Department of Rheumatology, Immunology, Osteology, and Physical Medicine, Campus Kerckhoff of Justus-Liebig-University Giessen, Bad Nauheim, Germany) ,  Huebschen Judith M. (World Health Organization European Regional Reference Laboratory for Measles and Rubella, Luxembourg Institute of Health, Department of Infection and Immunity, Esch-sur-Alzette, Luxembourg) ,  Khurana Claudia (Department of Pediatric Hematology and Oncology, Children’s Center Bethel, University Hospital Ostwestfalen-Lippe (OWL)/University Bielefeld, Bielefeld, Germany) ,  Kienle Korbinian (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ,  Klifa Roman (Immunology and Pediatric Hematology Department, Assistance Publique-Hopitaux de Paris (AH-PH), Paris, France) ,  Korn Klaus (Institute of Virology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuernberg, Erlangen, Germany) ,  Kutzner Heinz (Dermatopathology, Friedrichshafen, Germany) ,  Laemmermann Tim (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ,  Ledig Svea (Division of Pediatric Stem Cell Transplantation and Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Lipsker Dan (Faculte de Medecine, Universite de Strasbourg and Clinique Dermatologique, Hopitaux Universitaires, Strasbourg, France) ,  Meeths Marie (Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden) ,  Meeths Marie (Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden) ,  Meeths Marie (Theme of Children’s Health, Karolinska University Hospital, Stockholm, Sweden) ,  Naumann-Bartsch Nora (Division of Pediatric Hematology and Oncology, Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany) ,  Rascon Jelena (Center for Pediatric Oncology and Hematology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania) ,  Rascon Jelena (Faculty of Medicine, Vilnius University, Vilnius, Lithuania) ,  Schaenzer Anne (Institute of Neuropathology, Justus Liebig University Giessen, Giessen, Germany) ,  Seidl Maximilian (Institute for Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Seidl Maximilian (Institute of Pathology, Heinrich Heine University and University Hospital of Duesseldorf, Duesseldorf, Germany) ,  Tesi Bianca (Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden) ,  Tesi Bianca (Department of Clinical Genetics, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden) ,  Vauloup-Fellous Christelle (AP-HP, Hopital Paul-Brousse, Department of Virology, World Health Organization Rubella National Reference Laboratory, Groupe de Recherche sur les Infections pendant la Grossesse, University Paris Saclay, INSERM U1193, Villejuif, France) ,  Vollmer-Kary Beate (Institute for Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Warnatz Klaus (Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Warnatz Klaus (Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Wehr Claudia (Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Wehr Claudia (Department of Medicine I, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Neven Benedicte (Imagine Institute, Universite de Paris, Paris, France) ,  Neven Benedicte (Pediatric Hematology-Immunology and Rheumatology Department, Hopital Necker-Enfants Malades, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France) ,  Neven Benedicte (Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM UMR 1163, Imagine Institute, Universite de Paris, Paris, France) ,  Vargas Pablo (Institut Curie, Centre National de la Recherche Scientifique (CNRS) UMR 144 and Institut Pierre-Gilles de Gennes, and INSERM U932 Immunite et Cancer, Institut Curie, Paris Sciences et Lettres Research University, Paris, France) ,  Sepulveda Fernando E. (Molecular Basis of Altered Immune Homeostasis Laboratory, Institut National de la Sante et de la Recherche Medicale (INSERM), Unite Mixte de Recherche (UMR) 1163, Paris, France) ,  Sepulveda Fernando E. (Imagine Institute, Universite de Paris, Paris, France) ,  Sepulveda Fernando E. (Centre National de la Recherche Scientifique (CNRS), Paris, France) ,  Lehmberg Kai (Division of Pediatric Stem Cell Transplantation and Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Schmitt-Graeff Annette (Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany) ,  Ehl Stephan (Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany)
資料名： Journal of Allergy and Clinical Immunology  (Journal of Allergy and Clinical Immunology)
巻： 149  号： 1  ページ： 388-399.e4  発行年： 2022年 
JST資料番号： A0182B  ISSN： 0091-6749  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： Rubellaウイルス誘導肉芽腫は,免疫の様々な先天性エラーを有する患者で記述されている。ほとんどの欠損はT細胞免疫を損ない,風疹除去におけるT細胞の重要な役割を示唆した。しかし,ウイルス制御の分子機構は不明である。本研究は,肉芽腫における風疹ワクチンウイルスの持続性を可能にする欠陥エフェクター機構を理解することを試みた。Griscelli症候群2型および風疹皮膚肉芽腫のインデックス症例から始めて,この研究は,細胞毒性欠損および肉芽腫患者を同定するための文献検索と国際調査を組み合わせた。研究者は風疹ウイルス免疫組織化学およびPCRおよびT細胞移動アッセイを実施した。本研究では,皮膚および内臓肉芽腫を呈する様々な遺伝的に確認された細胞毒性欠損を有する21人の患者を同定した。Rubellaウイルスは全12のアクセス可能な生検で示された。肉芽腫発症は典型的には2歳前であり,病変は数か月から数年持続した。顆粒腫はMUNC13-4とRAB27A欠損で特に高頻度であり,リスクの患者の50%が影響を受けた。これらの蛋白質はリンパ球移動にも関与していたが,三次元移動アッセイは患者T細胞の移動障害の証拠を示さなかった。特に,患者は,同時投与した麻疹,ムンプス,または,他のウイルスによる重症感染の,同時に与えられた麻疹のコントロール低下の証拠を示さなかった。本研究は,生きた麻疹,ムンプス,または水痘ワクチンの制御におけるその必要性の証拠なしで,風疹ワクチンウイルスの制御のための主要なエフェクター機構としてリンパ球細胞毒性を同定した。Rubellaワクチン誘導肉芽腫は,細胞毒性の遺伝的障害の不完全な透過性を有する新規表現型である。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *遺伝 ,  タンパク質 ,  *表現型 ,  麻疹 ,  *ワクチン ,  *風疹 ,  T細胞 ,  風疹ウイルス ,  流行性耳下腺炎 ,  *肉芽腫 ,  *風疹ワクチン ,  *細胞毒性 ,  生検 ,  三次元 ,  免疫組織化学

著者キーワード (7件)： 細胞毒性 ,  風疹ウイルス ,  生ワクチン ,  肉芽腫 ,  原発性免疫不全 ,  血球貪食性リンパ組織球症 ,  Griscelli症候群2型

分類 (1件)： 感染症・寄生虫症一般  (GD01010H)

タイトルに関連する用語 (6件)： 風疹ワクチン ,  誘導 ,  肉芽腫 ,  細胞毒性 ,  欠損 ,  表現型