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J-GLOBAL ID：202202293671041649   整理番号：22A0004104

2型糖尿病と血漿金属レベルの関連性およびマイクロRNAの媒介効果【JST・京大機械翻訳】

Associations of plasma metal levels with type 2 diabetes and the mediating effects of microRNAs

著者 (16件)： Nie Hongli (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  Hu Hua (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  Li Zhaoyang (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  Wang Ruixin (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  He Jia (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  He Jia (Department of Public Health, Shihezi University School of Medicine, Shihezi, 832000, Xinjiang, China) ,  Li Peiwen (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  Li Weiya (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  Cheng Xu (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  An Jun (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  Zhang Zefang (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  Bi Jiao (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  Yao Jinqiu (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  Guo Huan (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  Zhang Xiaomin (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) ,  He Meian (Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China)
資料名： Environmental Pollution  (Environmental Pollution)
巻： 292  号： PB  ページ： Null  発行年： 2022年 
JST資料番号： D0984B  ISSN： 0269-7491  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 本研究は,糖尿病リスクと複数の血漿金属レベルと血漿マイクロRNA(miRNAs)の関連性を決定し,さらに糖尿病リスクと血漿金属との関連に対する血漿miRNAの媒介効果を調査することを目的とする。94名の新規診断と非治療糖尿病症例と94名の健常対照者の間で,誘導結合プラズマ質量分析(ICP-MS)により23金属の血漿レベルを検出した。血漿miRNAsは,同じ研究集団の間でマイクロRNAアレイスクリーニングとTaqmanリアルタイムPCR検証によって調べられた。多変量ロジスティック回帰モデルを用いて,糖尿病リスクと血漿金属とmiRNAレベルの関連を調べた。一般化線形回帰モデルを用いて,血漿金属と血漿miRNA間の関係を調べ,血漿金属と糖尿病リスクの間の関係に対する血漿miRNAの仲介効果を評価するために,仲介分析を用いた。血しょうアルミニウム(Al),チタン(Ti),銅(Cu),亜鉛(Zn),セレン(Se),ルビジウム(Rb),ストロンチウム(Sr),バリウム(Ba),およびタリウム(Tl)レベルは糖尿病リスクの上昇と相関したが,糖尿病リスク低下を伴うモリブデン(Mo)(FDR多重補正後P<0.05)と相関した。MiR-122-5pとmiR-3141は,糖尿病リスクと正に相関した(すべてのP<0.05)。Ti,CuおよびZnはmiR-122-5pと正相関した(それぞれP=0.001,0.028および0.004)。Ti,CuおよびSeはmiR-3141と正相関した(それぞれP=0.003,0.015および0.031)。さらに,ZnはmiR-193b-3pと正相関した(P=0.002)。TiはmiR-26b-3pと負に相関した(P=0.016)が,MoとmiR-26b-3pは正相関した(P=0.042)。仲介分析において,miR-122-5pは,Tiと糖尿病リスクの間の関連の48.0%を媒介した。関連の生物学的機構は,さらなる研究で調査する必要がある。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： プラズマ ,  亜鉛 ,  セレン ,  チタン ,  モリブデン ,  *血漿 ,  血漿中濃度 ,  *糖尿病 ,  ICP-MS分析 ,  順相 ,  *2型糖尿病 ,  症例対照研究 ,  リアルタイムPCR法
準シソーラス用語： *マイクロRNA ,  線形回帰モデル , 【Automatic Indexing@JST】

著者キーワード (5件)： プラズマ金属 ,  2型糖尿病 ,  症例対照研究 ,  マイクロRNA ,  仲介効果

分類 (2件)： 重金属とその化合物一般  (SB05021R) ,  動物に対する影響  (EE05040R)

タイトルに関連する用語 (4件)： 2型糖尿病 ,  血漿 ,  関連性 ,  マイクロRNA