Uezono Yasuhito

2021 - 2024 オピオイド受容体の細胞内局在と活性変化に基づく最適なオピオイド順次投与法の確立

2021 - 2024 がん口腔支持医療における半夏瀉心湯の有用性を明らかにするための基礎及び臨床研究

2021 - 2024 がん患者のせん妄発症を予防する抑肝散、および口腔粘膜炎の早期治癒に資する半夏瀉心湯のメタボローム解析によるレスポンダーバイオマーカーの開発ならびに「証」の可視化とその臨床応用

2021 - 2024 せん妄ハイリスクがん患者の術後せん妄予防におけるラメルテオンの有効性と安全性に関する多施設共同二重盲検化プラセボ対照ランダム化比較試験

2021 - 2024 ヒトiPS細胞由来心筋細胞を用いた抗がん剤の心毒性評価法の開発と国際標準化

2020 - 2023 難治性疼痛に対するヒト間葉系幹細胞による鎮痛作用のメカニズム解明とその臨床応用

2018 - 2023 リアルタイム可視化アッセイによるオピオイド受容体細胞内動態解析と新規鎮痛法の開拓

2018 - 2021 Development of novel, specific heterodimerized opioid agonists with less tolerance and side effects

2017 - 2021 Elucidation of risk factors and establishment of new treatment methods for oral complications of cancer patient by salivary metabolome analysis

2018 - 2021 外科的がん切除後のデクスメデトミジンによる鎮静に不応な重症せん妄発症を予測するバイオマーカーの開発

2017 - 2020 Study on taste disorders and its treatment strategies: A comparative study between Japan and Thailand

2016 - 2020 Analysis to reveal the roles of TREK1 on cancer pain and to develop TREK1 agonists as novel analgesics for cancer patients

2016 - 2020 Investigation of the mechanism of opioid tolerance formation by visualization real-time analysis and development of new analgesic methods

2015 - 2019 Discovery of novel Nav1.7 inhibitors by using bioinformatics

2015 - 2019 Influence of cancer progression on central fluid regulation and its mechanism

2015 - 2019 Analysis of the role of Gs and Gi protein coupled receptors in the mechanism of action of anesthetics and analgesics

2015 - 2018 Research and development of novel mu and delta opioid receptor-specific analgesics

2015 - 2018 A pharmacological and clinical study of G protein-coupled antidepressant receptors on astrocytes

2013 - 2017 Comparative study on taste sensitivity between Japan and Thailand

2013 - 2017 Optimization of opioid therapy based on the diversity of dimerized opioid receptors

2013 - 2017 Does Aquaporin channel have an important role in cancer ascites?

2012 - 2016 Internalization and recycling profiles of dimeric opioid receptors induced by remifentanil ; Implication for the mechanism of tolerance and hyperalgesia

2015 - 2016 漢方薬および生薬有効成分、ならびに食物含有有効成分の安全性・有効性を科学的、客観的に評価する手法の開発

2013 - 2015 Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans.

2012 - 2015 Management of intolerable pain: development of novel methods for the persistent analgesia by simultaneous activation of heterodimerized Gi-coupled receptors

2011 - 2015 The pharmacological analysis of anesthetics in Dorsal root ganglia

2011 - 2015 Analysis of the molecular mechanism of the interaction of heterodimerized m-opioid and CB1 receptors

2010 - 2013 Development of mechanism-based novel medicaments to pain in advanced cancer

2011 - 2013 Investigation of the relationship between opioid kappa receptor subtype and receptor dimerization

2011 - 2013 Analysis of central water homeostasis in pathophysiology of cancer cachexia

2011 - 2013 The effect of anesthetics on opioid receptor

2010 - 2012 Improvement of QOL for cancer patients by a traditional Japanese medicine: Ameliorative effects of cachexia by rikkunshito through ghrelin receptors

2010 - 2012 Influence of the chronic pain on skin wound healing

2010 - 2012 Analysis of analgesic action of remifentanil through dimerized mu-delta opioid receptors

2010 - 2011 Identification of tumor-cell producing novel endogenous analgesic substance

2009 - 2011 Overcoming refractory pain : prevention of tolerance of pain by simultaneous activation of G_<i/o>-coupled receptors

2009 - 2011 Internalization and recycling profiles ofμ-and dimerizedμ-δopioid receptors induced by remifentanil : implication of acute tolerance of remifentanil.

2009 - 2011 Internalization and recycling profiles ofμ-opioid receptors induced by remifentanil ; Implication for the mechanism of tolerance and hyperalgesia

2008 - 2010 The molecular mechanism of the prion protein and the homolog which cause the neuro-degenerative/-protective function.

2008 - 2010 Internalization profiles of dimerized opioid receptors ; Implication for the mechanism of tolerance

2008 - 2009 Gi/o共役型受容体同時活性化による持続的鎮痛療法の開発

2007 - 2008 The study on the G protein coupled receptors to find the new analgesics

2007 - 2008 Overcome of intolerable pain : improvement of intrathecal drugapplication and its clinical use.

2007 - 2008 The analgesic effects of intrathecal morphine and baclofen for refractory pain

2006 - 2008 The study of anesthetics and analgesics on opioid receptors

2006 - 2007 麻酔薬作用における中枢神経系各部位の果たす役割解析

2005 - 2007 The study of the pain mechanisms using rat dorsal root ganglia

2005 - 2007 The role of the metabotropic gultamete receptor in the pain mechanism

2005 - 2006 Attempt of obstinacy pain easing by spinal cord GABA-B receptor continuation activation.

2004 - 2006 麻酔薬、鎮痛薬の痙攣誘発作用におけるセロトニン受容体のはたす役割解明

2001 - 2006 G蛋白共役型受容体の多量体化・複合体化とシグナル伝達機構との関連

2004 - 2005 Analysis of body GABAB receptor of two hetero amounts that makes creation of improvement of movement in digestive tube medicine target

2004 - 2005 麻酔薬の動脈硬化予防作用の臨床応用を目指した研究-麻酔薬の新たなる作用の検討-

2003 - 2005 The study of antinociceptive effects of anesthetics and analgesics using dorsal root ganglia cells.

2003 - 2004 Identification of factors that modify either the heterodimerization of G protein-coupled receptors or the trafficking of heterodimerized receptors to the cell surface

2003 - 2004 Analysis of the neuroendocrine system in PAC1 knock out mice

2002 - 2004 The effects of anesthetics and ethanol on cannabinoid receptor function.

2001 - 2004 Analysis of singaling mechanisms via heteromultimized or dimerized G protein-coupled receptors.

1997 - 2004 G蛋白共役型受容体から成長因子によるシグナル経路へのクロストーク

2002 - 2003 G蛋白質共役型受容体発現調節に関わる補助因子をターゲットとした創薬研究の基盤確立

2002 - 2003 ニューロステロイドのG蛋白結合受容体及びリガンド結合イオンチャンネルに及ぼす影響

2001 - 2002 Regulatory mechanism of aquaporin expression in cerebral microvessels : its pathophysiological significance

2001 - 2002 Analysis of the molecular mechanisms of formation and trafficking to the cell surface of the G protein-coupled receptors that require accessory proteins for their expression.

1999 - 2002 The role of ATP and purinoceptor in osteoblast-like cell proliferation induced by mechanical stimulation

1998 - 2002 Physiological function and gene expression of adremnomedullinfamily : adrenal medullary cells and isolated blood vessels

2000 - 2001 Analysis of prostaglandig-mediated regulatory mechanisms in the neuronal and endocrine systems

2000 - 2001 Regulation of cell surface expression of voltage-dependent sodium channels by multiple calcium signalings : their mRNA levels and intracellular trafficking

1999 - 2000 Identification and analysis of factors that regulate cell surface expression of G-protein coupled receptor

1999 - 2000 Modulation of sympathetic nervous system by environmental estrogens : Molecular and pharmacological analysis in adrenal medulla

1998 - 1999 Naチャネルの細胞膜発現調節:サブユニットmRNA変動と細胞内輸送・局在化機構

1997 - 1998 Electrophysiological and molecular biological analysis on GABA_Breceptors in hypothalamic neuroendocrine cells

1997 - 1998 Molecular and pharmacological analysis of the noradrenaline transporter

1995 - 1995 副腎髄質細胞の刺激一分泌連関の再構成とその解析〜アフリカツメガエル卵母細胞発現系を用いて〜

1995 - 1995 ラット大脳及び血管平滑筋からのアドレノメデュリン受容体のクローニングと機能解析-電気生理学的手法による機能性クローニング法を用いて-

1994 - 1994 血圧降下作用を持つペプチドアドレノメデュリンの受容体クローニングとその機能解析-電気生理学を用いた新しい機能性クローニング法によるアプローチ-

1991 - 電気生理学的手法を用いての受容体のクローニングと機能的アッセイ

Cross-talk signaling from G-protein coupled receptors to growth factor-mediated pathway

Cloning and functional characterization of receptors with electrophysiological methods