HIGUCHI KEIICHI

2016 - 2020 Molecular pathogenesis of amyloidosis: Integration of protein chemistry, mouse models and clinical pathology

2015 - 2018 The preventive effects of exercise + milk product intake on lifestyle-related diseases and heat illness: the establishment of remote research system on a large population of subjects

2014 - 2018 Analysis of Amyloid Related Proteins with Advanced Laser Microdissection

2014 - 2017 Development of preventive and therapeutic treatments based on the pathogenesis of the transmission of amyloidosis

2014 - 2017 Molecular design of novel phenylpropanoid-derived anti-amyloidal compounds using quantum-dot probes

2013 - 2016 Development and application of a reporter bioassay system to screen for phytochemicals mimicking the anti-aging effects of caloric restriction

2013 - 2016 Molecular pathological environments promoting/inhibiting the development of amyloidosis: the synergistic interaction of protein science and animal models

2013 - 2016 Changes in expression of L-type calcium channel subunits in skeletal muscle with aging.

2012 - 2016 Preventive effects and molecular mechanisms for metabolic abnormalities by a short-term intervention of caloric restriction and exercise

2012 - 2015 The mechanisms for deterioration of thermoregulatory responses in older people and the counter measure against their heat illness

2011 - 2014 Pathological Investigation of the Pathogenesis and Development of Preventive and Therapeutic Procedures for Amyloidosis

2011 - 2013 Molecular modeling of anti-amyloidal catechol derivatives using amyloidogenic proteins

2011 - 2013 Comprehensive Proteome Analysis of Age-related Changes in Amyloid Like Aggregates

2010 - 2012 Clarification of the molecular pathogenesis of human amyloidosis by in vitro amyloid fibril formation systems and transgenic mouse model

2010 - 2011 アミロイド線維の伝播によるタンパク質社会の秩序破綻と回復機構の解析

2009 - 2011 Health promotional effects of the combination of supplementation and exercise in old mice having various genetic backgrounds

2008 - 2010 Systemic analysis of amyloidosis using animal models

2006 - 2008 Use of genetically altered mice to develop new preventives against familial amyloidoses.

2006 - 2008 Molecular pathogenesis of dialysis-related amyloidosis-A fusion of the in vitro model and the animal model-

2005 - 2008 Molecular-genetic analysis of age related hearing impairment

2005 - 2007 a-adrenergic receptor responsiveness and baroreflex control of muscle blood flow:human and animal studies

2005 - 2007 Investigation into the pathogenesis of amyloidosis using the newly developed animal models.

2005 - 2006 アミロイドーシス伝播機構解明と感染物質検出システムの開発

2005 - 2006 病的構造タンパク質(アミロイド線維)の伝播及び形成機構の解析

2005 - 2006 熟年体育大学を基盤とした運動効率関連遺伝子の探策

2003 - 2005 Elucidation of the molecular pathogenesis of dialysis-related amyloidosis.

2004 - 2004 骨粗鬆症モデルマウス(SAMP6)を用いた骨量決定遺伝子群の同定

2003 - 2004 病的構造タンパク質(アミロイド線維)の伝播及び形成機構の解析

2003 - 2004 RESEARCH ON THE MOLECULAR MECHANISM UNDERLYING THE TRANSMISSION PHENOMENON IN AMYLOIDOSES INVOLVING HUMAN NEUROLOGICAL SYSTEMS

2002 - 2004 Molecular Genetic Analysis of Senescence-Accelerated Mouse (SAM)

2003 - 2003 骨粗鬆症モデルマウス(SAMP6)を用いた骨量決定遺伝子群の同定

2003 - 2003 アミロイド線維による伝播/感染機構と宿主応答の解析

2002 - 2003 Analysis and application of newly discovered rat L1 retotransposon

2002 - 2003 新たに発見された活性型L1レトロトランスポゾンの実験病理学への応用

2001 - 2003 A new exercise training program for the elderly by developing a novel handy calorie meter and an IT network system after the determination of human genome sequences.

2002 - 2002 骨粗鬆症モデルマウス(SAMP6)を用いた骨量決定遺伝子群の同定

2002 - 2002 アミロイドタンパク質の病的構造伝播機構の解析

1999 - 2001 Effects of restricted food intake and spontaneous wheel running on aging and longevity in senescence-accelerated mouse ( SAM )

1997 - 2001 Roles of molecular chaperones in cell function

2000 - 2000 自然突然変異型OGG1を持つマウス群を用いたDNA酸化傷害と発がんとの関連の解明

1999 - 2000 Analysis of the mechanism of misfolding to amyloid protein using mouse amyloidosis

1999 - 2000 Analysis of repair systems for oxidative DNA damage in Senescence-Accelerated Mouso

1999 - 2000 マウス個体老化の分子的把握:老化臓器の遺伝子発現レパートリィの作成

1998 - 1998 アミロイド蛋白(apoA-II)の線維構造への変換を制御する分子シャペロン

1997 - 1998 Studies of the Pathogenesis of Amyloidosis : Verification of the Hypothesis 'Transmission of Abnormal Proteins Structure' Using Mouse Senile Amyloidosis.

1997 - 1998 Molecular and Cellular Basis of Senescence Acceleration

1997 - 1997 マウスアミロイド蛋白(apoA-II)の構造交換と分子シャペロン

1996 - 1997 Effect protein deficiency on lnsulin like growth factor-I and lnsulin like growth factor-II gene expression physiological reles of lnsulin like growth factors as a local factore in growing lambs-

1996 - 1997 Relationship between age-related immune dysfunction and senile amyloidosis in shortened life length in SAM mice

1995 - 1996 Development of the Gene Therapeutic Treatment to Mouse Senile Amyloidosis

1991 - 1993 Comprehensive studies on age-related deficits in learning and memory in SAM

1991 - 1992 Molecular genetic analysis of muirne senile amyloidosis.

1990 - 1992 Development of murine models for aging brain, Senescence-Accelerated Mouse (SAM)

1990 - 1990 ApoB mRNAに出現するゲノDNAにコ-ドサれないストップコドンに関する研究

1989 - 1990 Modulatory Effect of Dietary Restriction on the Advance of Senescence in Senescence Accelerated Mouse (SAM)

1989 - 1990 Molecular Genetic Study of Mouse Senile Amyloidosis

1989 - 1989 ApoBmRNAに出現するゲノムDNAにコ-ドされないストップコドンに関する研究

1987 - 1988 A New Strain of Mice with Late-appearing Cataract, It's development from Senescence Accelerated Mouse (SAM) and characters of cataract.

1986 - 1988 Experimental studies on the pathogenesis and modulation of age-related pathologies in Senescence Acelerated Mouse (SAM).

リポタンパク質特にHDLの代謝調整の基礎的研究

アミロイド-シス発祥機構の分子生物学的研究

マウス特に老化促進モデルマウス(SAM)を用いた老化、寿命、老化病態の遺伝的要因の解析