Akai Shuji

アカイシュウジ | Akai Shuji

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://handai-seizo.jp/

Research field (4)： Pharmaceuticals - chemistry and drug development , Synthetic organic chemistry , Bioorganic chemistry , Structural/physical organic chemistry

Research keywords (6)： synthetic organic chemistry , enzymatic catalysts , catalyst chemistry , medicinal chemistry , fluorine chemistry , organic chemistry

Research theme for competitive and other funds (27)：

2022 - 2026 Synergy of biocatalysts and transition metal catalysts: Innovative syntheses of optically pure, highly functional organic compounds
2021 - 2024 高分子薬の有効化に寄与する癌微小環境改善薬の開発
2021 - 2024 Sustainable Asymmetric Synthesis: Collaboration of Enzymes and Metal Catalysts
2018 - 2022 Development of Cooperative Chemo- and Biocatalysts and their Application in the Practical Synthesis of Biologically Active Molecules
2018 - 2021 Multistep one-pot asymmetric synthesis by enzyme-metal combo-catalysis

2018 - 2020 Continuous flow synthesis by integrated reactions: Efficient synthesis and transformation of naturally occurring bioactive middle molecules

2016 - 2018 加水分解酵素との触媒集積化による生物機能分子の高効率不斉合成

2015 - 2018 次世代型多触媒動的光学分割法の開発とドミノ型不斉合成への応用

2015 - 2018 Development of enzymatic multi-step one-pot reactions using nanoporous inorganic materials

2014 - 2016 Development of highly selective synthetic methods by utilizing unique nano space of porous inorganic materials

2012 - 2014 金属と酵素の複合固定化触媒による反応集積型不斉合成法の開発

2009 - 2011 The development of innovative asy mmetric synthetic methods by the enzyme-metal combo catalysis

2005 - 2006 Construction of Carbon Skeleton via Lipase-Catalyzed Domino-Type Syntheses with Dynamic Kinetic Resolution

2001 - 2005 Environmentally benign reactions for large-scale syntheses of bioactive natural products and their application to drug discovery

2003 - 2004 Development of Lipase-Catalyzed Domino-Type Asymmetric Syntheses

2001 - 2002 Development of New Method for Construction of Chiral, Non-Racemic Quaternary Carbon Center by Enzymatic Acylation of Alcohols and Application Thereof

1999 - 2000 Development of Lipase-Catalyzed, Effective, Asymmetric Synthetic Methods

1997 - 1998 Effective Enzymatic Kinetic Resolution of Alcohols using Reactive Ketene-acetal Acylating Reagents

1995 - 1996 Practical Application of Ketene Acetal-type Reactive Acylating Reagents

リパーゼ触媒不斉合成反応の開発研究

酵素を用いる不斉合成反応の開発研究

生物活性天然化合物

硫黄原子の特性を利用する新規合成反応の開発研究

Development of Lipase-Catalyzed Asymmetric Synthetic Methods

Development of asymmetric synthetic methods using enzymes

Total Synthesis of Biologically Active Natural Products

Development of novel synthetic methods utilizing sulfur-functional groups

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Papers (238)：

Neha Dhiman, Gamal A. I. Moustafa, Kengo Kasama, Hiroshi Aoyama, Kyohei Kanomata, Harald Gröger, Shuji Akai. Dynamic Kinetic Resolution of 2-Hydroxybiaryl Atropisomers via Lipase-Catalyzed Enantioselective O-Acylation. ChemCatChem. 2024
Riku Ogasahara, Kazuho Ban, Miyu Mae, Shuji Akai, Yoshinari Sawama. Deuterated Alkyl Sulfonium Salt Reagents; Importance of H/D Exchange Methods in Drug Discovery. ChemMedChem. 2024. 19. 16
Satoshi Horino, Karla Wagner, Anke Hummel, Kyohei Kanomata, Harald Gröger, Shuji Akai. Kinetic Resolution of Cyclic Tertiary Alcohols with Lipase A from Candida Antarctica. European Journal of Organic Chemistry. 2024. 27. 21
Karla Wagner, Anke Hummel, Jianing Yang, Satoshi Horino, Kyohei Kanomata, Shuji Akai, Harald Gröger. Protein engineering of lipase A from Candida antarctica to improve esterification of tertiary alcohols. Chembiochem : a European journal of chemical biology. 2024. e202400082
Takaaki Aijima, Rina Ueda, Takanori Nakane, Fumiaki Makino, Yusuke Ohnishi, Jin Tokunaga, Keiichiro Nakajima, Shinichiro Kamino, Genji Kurisu, Keiichi Namba, et al. Versatile Biaryls and Fused Aromatics through Oxidative Coupling of Hydroquinones with (Hetero)Arenes. ChemistrySelect. 2024. 9. 15

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MISC (16)：

牧野雅義, 駒川晋輔, 井川貴詞, 赤井周司. Computational Study of Solvent Effects on Racemization of Optically Pure Propargyl Alcohols. 日本薬学会年会要旨集(Web). 2020. 140th
井川貴詞, 衣斐勇人, 野崎俊史, 繁田尭, 守川由起, 赤井周司. ベンザインとフランの位置選択的Diels-Alder反応を連続的に利用するaloinの合成研究. 複素環化学討論会講演要旨集. 2018. 48th
井川貴詞, 衣斐勇人, 野崎俊史, 繁田尭, 守川由起, 赤井周司. ベンザインを用いるアロインの合成研究. 日本薬学会年会要旨集(CD-ROM). 2018. 138th
Takashi Ikawa, Shigeaki Masuda, Akira Takagi, Tsuyoshi Nishiyama, Shuji Akai. Synthesis of aryl fluorides through one-pot benzyne generation/nucleophilic fluorination. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2014. 248
Takashi Ikawa, Hirohito Urata, Yutaka Fukumoto, Tsuyoshi Nishiyama, Shuji Akai. Silicon directed Diels-Alder reactions of 3,4-pyridynes for the synthesis of multisubstituted isoquinolines. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2014. 248

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Books (14)：

Recent Trends in Flow Microreactor Synthesis
2021 ISBN:9784781316154
Modern Organic Industrial Chemistry
2020 ISBN:9784759820256
Dynamic Kinetic Resolution for Asymmetric Synthesis: Synergy of Enzyme and Metal Catalysts
Academic Press 2018
Hydrolase-Catalyzed Dynamic Kinetic Resolution of Racemic Alcohols
Future Directions in Biocatalysis, 2nd Edition”. Ed. by Tomoko Matsuda, Elsevier, 2017, Chapter 16 2017 ISBN:9780444637437
ベーシック薬学教科書シリーズ5 有機化学, 第2版
化学同人 2016

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Education (3)：

1984 - 1987 Osaka University Graduate School of Pharmaceutical Sciences Doctoral course
1982 - 1984 Osaka University Graduate School of Pharmaceutical Sciences Master's course
1978 - 1982 Osaka University School of Pharmaceutical Sciences

Professional career (1)：

(BLANK)

Work history (6)：

2013/03 - 現在 Osaka University Graduate School of Pharmaceutical Sciences Professor
2005/06 - 2013/03 University of Shizuoka School of Pharmaceutical Sciences Professor
2005/04 - 2005/05 Osaka University Graduate School of Pharmaceutical Sciences Associate Professor
1989/04 - 2005/03 Osaka University School of Pharmaceutical Sciences Assistant Professor
1997/05 - 1998/05 MEXT Overseas Researcher MIT Visiting Researcher

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Awards (8)：

2023/03 - 日本薬学会 2023年度日本薬学会賞持続可能な社会構築に資する高選択的精密合成の開発と医薬学への応用
2014 - Asian Core Program Lectureship Award Dynamic Kinetic Resolution of Racemic Alcohols by Vanadium-Lipase Combo Catalysis
2013 - 日本学術振興会平成24年度特別研究員等審査会専門委員表彰
2012 - Excellent Poster Award Dynamic Kinetic Resolution of Racemic Allyl Alcohols by Lipase-Vanadium Combo Catalysis
2011/08 - JSPC Award for Excellence 2011 Asymmetric Synthesis of Allyl Esters via Vanadium-Lipase Combo Catalyzed Dynamic Kinetic Resolution

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Association Membership(s) (16)：

臨床医薬品化学研究会 , フロー・マイクロ合成研究会 , 生体触媒化学研究会 , The Kinka Chemical Society, Japan , International Society of Heterocyclic Chemistry , The Society of Fluorine Chemistry, Japan , 日本プロセス化学会 , 日本化学会 , アメリカ化学会 , 有機合成化学協会 , 日本薬学会 , The Japanese Society for Process Chemistry , The Chemical Society of Japan , American Chemical Society , The Society of Synthetic Organic Chemistry, Japan , The Pharmeceutical Society of Japan

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