Rchr
J-GLOBAL ID:200901001794809709
Update date: Nov. 19, 2024
Tanokura Masaru
タノクラ マサル | Tanokura Masaru
Affiliation and department:
Homepage URL (1):
http://park.itc.u-tokyo.ac.jp/Yojokun/
Research field (3):
Food sciences
, Biophysics
, Structural biochemistry
Research keywords (6):
食品科学
, 生物物理学
, 構造生物化学
, Food Science
, Biophysics
, Structured Biochemistry
Research theme for competitive and other funds (51):
- 2018 - 2021 Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism
- 2015 - 2019 Neuronal differentiation of MUSE cells mediated by neuronal differentiation control peptides and application to neuronal regeneration medicine
- 2015 - 2018 Sperm recognition domain in mammalian egg coat matrix
- 2015 - 2018 Mechanism of effectof XOR inhibitors on delay of progress of neurodegenerative diseases
- 2016 - 2017 Analysis of age-related metabolic changes in mitochondria of Caenorhabditis elegans
- 2013 - 2016 Mechanisms for acquiring ability to degrade novel compounds in sphingomonads and their applications
- 2013 - 2016 Regulatory mechanism of ciliary functions by calaxin
- 2011 - 2016 Elucidation of aging regulatory mechanisms related to mitochondrial function and identification of anti-aging food factors
- 2012 - 2015 Sperm recognition domain in mammalian egg coat matrix
- 2012 - 2013 NMRを用いたメタボロミクス分析法の開発及び応用
- 2010 - 2012 Studies on molecular mechanisms for functional evolution of bacteria in the environment
- 2009 - 2011 Sperm recognition and matrix formation mechanisms of mammalian egg coats
- 2004 - 2006 ANALYSIS OF GENES AND PROTEINS RELATED TO COCHLEAR DAMAGE USING DNA MICROARRAY AND PROTEOMICS
- 2001 - 2005 Investigation of immuno-regulatory competency of dietary substances and its application for our own beneficial ends
- 2003 - 2004 New Methods for Measuring Heteronuclear Long Range Coupling Constants and Proton-Proton Coupling Constants
- 2003 - 2004 Improvement of Functions of Novel Enzymes in the Desulfurization Metaoblism of Petroleum by Protein Engineering and Molecular Genetics
- 2003 - 2004 Three dimensional structures of HCE and LCE and its mechanism of egg envelope digestion
- 2003 - 2003 WWドメインの機能と特異性に関する総合理解を目指した構造構能相関研究
- 2001 - 2003 Analysis of structure-function correlation of oryzacystatin and development of new functional foods
- 1998 - 2003 Structural Biology of Biological Machineries through X-ray Protein Crystallography Reinforced by Synchrotron Radiation
- 2001 - 2002 Development of the ^<31>P-NMR Probe with ultra high sensitivity and analysis of phosphate binding proteins, related to signal transduction
- 1999 - 2002 発光細菌の発光反応関連酵素群のX線結晶構造解析
- 1999 - 2000 X-Ray Crystallography of Flavin Reductase and Its Mutants
- 2000 - NMRによる食品の非破壊分析
- 1997 - 1999 Analysis of structure-function relationships on smooth muscle myosin using NMR and X-ray crystallography.
- 1998 - 1998 ブロメラインインヒビターの3次元構造解析とそれに基づく阻害剤の開発
- 1998 - 1998 X線とNMRによるクロコウジカビ酸性プロテアーゼAの折れたたみ機構の解析
- 1997 - 1997 キネシンとncdのNMRによる動的構造の解析
- 1997 - 1997 ブロメラインインヒビターの3次元構造解析とそれに基づく阻害剤の開発
- 1997 - 1997 NMRとX線によるクロコウジカビ酸性プロテアーゼAの折れたたみ機構の解析
- 1993 - 1997 Millisecond Order Dynamics of Protein Crystal Structure Using Syncrotron Radiation.
- 1996 - 1996 NMRとX線によるクロコウジカビ酸性プロテアーゼAの折れたたみ機構の解析
- 1993 - 1996 時間分割ラウエ法利用研究
- 1995 - 1995 NMRとX線小角散乱によるクロコウジカビ酸性プロテアーゼAの折れたたみ機構の解析
- 1994 - 1994 大腸菌ATP依存性プロテアーゼLonの構造と機能
- 1993 - 1994 Three-dimensional structural analysis of non-pepsin-type acid proteinase using NMR and x-ray crystaliography
- 1993 - 1994 Studies on Carboxyl Proteinases : Comparative Analysis of Functional Structures and Catalytic Mechanisms of Proctases A and B
- 1991 - 1991 りん核磁気共鳴法によるアクトミオシン反応中間体の立体構造の研究
- 1990 - 1991 Studies on the molecular properties and the structure-function relationships of carboxyl proteases of novel type
- 1989 - 1990 Conformation of Contractile Protein in its Transition State as Studied by Phosphorus-31 Nuclear Magnetic Resonance
- 1987 - 1989 Correlations between the mechanical and biochemical processes of muscle contraction by photogeneration of ATP.
- 立体構造に基づいた新しい機能を持ったタンパク質の創製
- 芳香族ニトロ(NO2)化合物分解酵素の応用
- 立体構造に基づいた新機能性タンパク質の創製
- タンパク質のX線結晶構造解析
- X-ray crystallography of proteins
- Design and production of proteins with novel functions on the basis of three-dimensional structures
- Application of enzymes to break down aromatic nitro compounds
- Design and production of novel functional proteins based on 3D structure
- NMR Study of Protein Conformation in Solution
- Protein Crystallography
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Papers (394):
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Feifei Wei, Masaru Tanokura. Changes in coffee beans during roasting. Coffee in Health and Disease Prevention. 2025. 125-137
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Mototaka Suzuki, Masayo Date, Tatsuki Kashiwagi, Kazutoshi Takahashi, Akira Nakamura, Masaru Tanokura, Eiichiro Suzuki, Keiichi Yokoyama. Random mutagenesis and disulfide bond formation improved thermostability in microbial transglutaminase. Applied Microbiology and Biotechnology. 2024. 108. 1
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Tsukasa Makino, Ryo Kanada, Teppei Mori, Ken-ichi Miyazono, Yuta Komori, Haruaki Yanagisawa, Shoji Takada, Masaru Tanokura, Masahide Kikkawa, Michio Tomishige. Tension-induced suppression of allosteric conformational changes explains coordinated stepping of kinesin-1. 2024
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Keiko Shibata, Harune Moriizumi, Koji Onomoto, Yuka Kaneko, Takuya Miyakawa, Shuhei Zenno, Masaru Tanokura, Mitsutoshi Yoneyama, Tomoko Takahashi, Kumiko Ui-Tei. Caspase-mediated processing of TRBP regulates apoptosis during viral infection. Nucleic Acids Research. 2024
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Ryo Tachibana, Susumu Abe, Momo Marugami, Ayumi Yamagami, Rino Akema, Takao Ohashi, Kaisei Nishida, Shohei Nosaki, Takuya Miyakawa, Masaru Tanokura, et al. BPG4 regulates chloroplast development and homeostasis by suppressing GLK transcription factors and involving light and brassinosteroid signaling. Nature Communications. 2024. 15. 1
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MISC (486):
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山中聡士, 山中聡士, 降旗大岳, 降旗大岳, 臼井麻衣, 長岡昂冶, 庄屋祐希, 西野耕平, 小迫英尊, 田之倉優, et al. ネオ基質分解制御のためのサリドマイド誘導体およびPROTACの開発. 日本生化学会大会(Web). 2023. 96th
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降旗大岳, 山中聡士, 本田敏章, 柴田哲男, 田之倉優, 澤崎達也, 宮川拓也. Structural bases for the degradation selectivity of C2H2 zinc finger by thalidomide metabolite. 量子ビームサイエンスフェスタ(Web). 2021. 2020
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楠林和貴, 宮園健一, 伊藤友子, 栗崎晃, 田之倉優. TGF-βシグナル主要伝達因子SMAD2及びSMAD3のMH2ドメインにおける性状比較. 日本生化学会大会(Web). 2020. 93rd
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楠林和貴, 宮園健一, 伊藤友子, 栗崎晃, 栗崎晃, 浅島誠, 田之倉優. Characteristics of MH2 domains of SMAD2 and SMAD3 in TGF-β signaling. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
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降旗大岳, 山中聡士, 本田敏章, 柴田哲男, 田之倉優, 澤崎達也, 宮川拓也. サリドマイド代謝物によるC2H2型ZFの分解選択性の構造基盤. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
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Patents (5):
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タンパク質結晶化方法
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平滑筋弛緩剤とその有効成分の抽出方法
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蛋白質の分離方法
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ザルコシン・オキシダーゼの結晶, その製造方法及び三次元構造
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リコンビナントMPOフラグメント及びそれを用いたMPO自己抗体の測定法.
Books (48):
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4.8 発生と分化. 入門 構造生物学-放射光X線と中性子で最新の生命現象を読み解く-(高エネルギー加速器研究機構構造生物学研究センター編 加藤龍一編集)165-172
共立出版, 東京 2010
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Effects of functional antioxidants on age-related hearing loss. Biotechnology in Functional Foods and Nutraceuticals
CRC Press, U. S. A. 2010
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老人性難聴におけるBak 依存性ミトコンドリアアポトーシスの役割
実験医学 28 (6), 917-920 2010
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Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys.
Curr. Aging Sci. 3 (1), 20-25. 2010
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近年の酵素・タンパク質結晶構造解析の進歩と展開
日本結晶学会誌 52 (1), 8-13. 2010
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Works (13):
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創薬等支援技術基盤プラットフォーム
2012 - 現在
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ターゲットタンパク研究プログラム
2007 - 2011
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ターゲットタンパク研究プログラム「キラル化合物の産業生産に有用な酵素の触媒反応機構の解明と高機能化」
2007 - 2011
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ターゲットタンパク研究プログラム「乾燥・高温ストレス耐性作物の開発に役立つ転写制御タンパク質の構造・機能解析」
2007 - 2011
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タンパク3000プロジェクト「発生・分化とDNAの複製・修復」
2002 - 2006
more...
Education (4):
- - 1979 The University of Tokyo
- - 1979 The University of Tokyo Graduate School, Division of Science
- - 1975 The University of Tokyo Faculty of Science
- - 1974 The University of Tokyo Faculty of Science
Professional career (2):
- Master of Science (The University of Tokyo)
- Ph.D. (The University of Tokyo)
Work history (13):
- 2017/06 - 現在 The University of Tokyo Professor Emeritus
- 2017/04 - 現在 The University of Tokyo Graduate School of Agricultural and Life Sciences Project Professor
- 1998/08 - 2017/03 The University of Tokyo Graduate School of Agricultural and Life Sciences Professor
- 1994/03 - 1998/07 The University of Tokyo Biotechnology Research Center Professor
- 1994 - 1998 Professor, University of Tokyo, Biotechnology Research Center
- 1993 - 1994 The University of Tokyo Graduate School of Science, Department of Biophysics and Biochemistry
- 1993 - 1994 Associate Professor, University of Tokyo, Graduate School of Science, Department of Biophysics and Biochemistry
- 1989 - 1993 The University of Tokyo Faculty of Science
- 1989 - 1993 Assssistant Professor, The University of Tokyo, Faculty of Science, Department of Biophysics and Biochemistry
- 1988 - 1989 Juntendo University Faculty of Medicine
- 1988 - 1989 Assssistant Professor, Juntendo University School of Medicine, Department of Pharmacology
- 1980 - 1988 Oita Medical University
- 1980 - 1988 Research Associate, Medical University of Oita School of Medicine
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Committee career (8):
- 2012/03 - 現在 日本農芸化学会関東支部 参与
- 2004/10 - 現在 日本食品免疫学会 評議員
- 1996/10 - 現在 日本生化学会 評議員
- 2011/10 - 2013/09 日本生化学会 理事
- 2009/01 - 2011/12 日本バイオイメージング学会 会長
- 2007/04 - 2011/03 日本蛋白質科学会 理事
- 1996/04 - 2006/03 日本動物細胞工学会 評議員,幹事
- 1998/10 - 2000/09 日本生物物理学会 運営委員
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Association Membership(s) (11):
日本蛋白質科学会
, American Society of Biochemistry and Molecular Biology
, Biophysical Society
, American Crystallographic Association
, Protein Society
, 日本動物細胞工学会
, 日本バイオイメージング学会
, 日本生物物理学会
, 日本農芸化学会
, 日本生化学会
, Biophysical society
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