Mizumoto Shuji

ミズモトシュウジ | Mizumoto Shuji

Affiliation and department：
Job title：准教授
Homepage URL (1)： https://scholar.google.co.jp/citations?hl=ja&user=b0ZTepcAAAAJ

Research field (8)： Genetics , Genomics , Pathobiochemistry , Developmental biology , Molecular biology , Pharmaceuticals - health and biochemistry , Cell biology , Structural biochemistry

Research keywords (25)：フィラミン , 糖鎖医学 , 糖鎖病態学 , RAGE , がん転移 , 神経・免疫・骨格異常症候群 , 脊椎骨端骨幹端異形性症 , エーラス・ダンロス症候群 , 遺伝病 , 結合組織疾患 , 皮膚疾患 , 骨系統疾患 , 包括脳ネットワーク , ヘパラン硫酸 , デルマタン硫酸 , コンドロイチン硫酸 , グリコサミノグリカン , プロテオグリカン , zebrafish , heparin , heparan sulfate , dermatan sulfate , chondroitin sulfate , glycosaminoglycan , proteoglycan

Research theme for competitive and other funds (12)：

2022 - 2023 多嚢胞性腎症におけるグリコサミノグリカンのクロストーク
2019 - 2022 プロテオグリカンとフィラミンのクロストークとその変異による遺伝性骨疾患
2019 - 2021 Crosstalk of chondroitin sulfate and filamin in hereditary bone dyaplasias
2018 - 2020 RAGEが関わる糖尿病合併症におけるグリコサミノグリカンの役割とその阻害効果
2016 - 2019 Golginによるグリコサミノグリカン生合成調節機構と遺伝性骨・皮膚疾患との関連

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Papers (97)：

Parker Wengryn, Felicity Fenrich, Karina da, Costa Silveira, Connor Oborn, Shuji Mizumoto, Alexander Beke, Carrie-Lynn Soltys, Shuhei Yamada, Peter Kannu. Integrative Analysis of Lunatic Fringe Variants Associated with Spondylocostal Dysostosis Type-III. The FASEB Journal. 2024. 38. 13. e23753
Lin Wang, Shuji Mizumoto, Ruixue Zhang, Yuqi Zhang, Yuan Liu, Wenjing Cheng, Xin Li, Min Dan, Chunyan Zhang, Xinru Gao, et al. Identification of a novel LFNG variant in a Chinese fetus with spondylocostal dysostosis and a systematic review. Journal of Human Genetics. 2024. 69. 7. 321-327
Hayato Ota, Hirokazu Sato, Shuji Mizumoto, Ken Wakai, Kei Yoneda, Kazuo Yamamoto, Hayao Nakanishi, Jun-Ichiro Ikeda, Shinichi Sakamoto, Tomohiko Ichikawa, et al. Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer. Scientific Reports. 2023. 13. 1. 11618-11618
Soichiro Saito, Shuji Mizumoto, Tsukasa Yonekura, Rina Yamashita, Kenta Nakano, Tadashi Okubo, Shuhei Yamada, Tadashi Okamura, Tatsuya Furuichi. Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis. PLoS One. 2023. 18. 4. e0284292
Shuji Mizumoto, Shuhei Yamad. Histories of Dermatan Sulfate Epimerase and Dermatan 4-O-Sulfotransferase from Discovery of Their Enzymes and Genes to Musculocontractural Ehlers-Danlos Syndrome. Genes. 2023. 14. 2. 509

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Patents (2)：

グリコサミノグリカン分解促進剤
ムコ多糖分解促進剤

Books (26)：

Hereditary neurological, immune, and connective tissue disorders caused by defect in glycosaminoglycans
The CELL (the New Science Co. Ltd.), 56(9), pp. 690-694 2024
Biochemistry in New Direction
Kyoto Hirokawa 2023
Editorial: Roles of Chondroitin Sulfate and Dermatan Sulfate as Regulators for Cell and Tissue Development
Frontiers in Cell and Developmental Biology, 10, 941178 2022
Application of anti-glycosaminoglycan antibody and biotinylated hyaluronan binding protein (bHABP) [5] ~ enzyme-linked immunosorbent assay for hyaluronan quantification
In: Glycoscience Protocols (GlycoPODv2), (Japan Consortium for Glycobiology and Glycotechnology; Shoko Nishihara, Kiyohiko Angata, Kiyoko F. Aoki-Kinoshita, Jun Hirabayashi eds) 2021
Application of anti-glycosaminoglycan antibody and biotinylated hyaluronan binding protein (bHABP) [1] ~ Characteristics and epitopes for anti-heparan sulfate antibodies
In: Glycoscience Protocols (GlycoPODv2), (Japan Consortium for Glycobiology and Glycotechnology; Shoko Nishihara, Kiyohiko Angata, Kiyoko F. Aoki-Kinoshita, Jun Hirabayashi eds) 2021

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Lectures and oral presentations (108)：

Glycostasis: A new paradigm for supra-multitasking molecule, “carbohydrates”
(The 97th Annual Meeting of the Japanese Biochemical Society 2024)
Role of glycosaminoglycans revealed by analysis of genetic disorders and knockout mice
(The 97th Annual Meeting of the Japanese Biochemical Society 2024)
ウリジン二リン酸によるグリコミサノグリカン生合成に関わる酵素の活性阻害
(糖鎖科学中部拠点第20回若手の力フォーラム 2024)
Inhibitory activity of UDP toward xylosyltransferase, glucuronyltransferase-I and UDP-GlcA-decarboxylase, which are involved in glycosaminoglycan biosynthesis
(5th Australasian Glycoscience Symposium 2024)
Glycobiology of hereditary disorders caused by defects in biosynthesis of chondroitin, dermatan, and heparan sulfate
(The Department of Pathology Seminar in University of Otago, New Zealand 2024)

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Education (1)：

2001 - 2006 Kobe Pharmaceutical University Research Division in Pharmacy

Professional career (1)：

Ph.D.

Work history (4)：

2019/04 - 現在 Meijo University Graduate School/Faculty of Pharmacy Associate Professor
2013/10 - 2019/03 Meijo University Faculty of Pharmacy
2017/04 - 2018/03 University of Otago, Dunedin School of Medicine, Department of Women’s and Children’s Health, Clinical Genetics Group (Stephen Robertson’s Lab) Visiting Researcher
2006/04 - 2013/09 Hokkaido University Faculty of Advanced Life Science

Committee career (11)：

2022/07 - 現在 Frontiers in Molecular Bioscience (Section for Glycoscience) Associate Editor
2020/07 - 現在 Genes (Section for Human Genomics and Genetic Diseases) Editorial Board member
2020/01 - 現在 Trends in Glycoscience and Glycotechnology Associate Editor
2020/01 - 現在 Forum: Carbohydrates Coming of Age Associate Secretary
2023/01 - 2023/01 糖鎖科学中部拠点第18回若手の力フォーラム世話人

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Awards (3)：

2018/06 - 日本薬学会東海支部日本薬学会東海支部学術奨励賞コンドロイチン/デルマタン硫酸の生合成不全による遺伝性の骨・皮膚疾患と肺癌転移の分子メカニズム
2016/09 - The Japanese Society of Carbohydrate Research Research Award for Japanese Society of Carbohydrate Research Glycobiological approaches for bone and skin disorders caused by deficiency of glycosaminoglycans and its role for tumor metastasis
2015/08 - 9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium Travel Award

Association Membership(s) (11)：

The Japanese Society of Bone and Mineral Research , The American Society for Biochemistry and Molecular Biology (U.S.A.) , The Japan Society of Human Genetics , The Japanese Society of Cartilage Metabolism , Society for Glycobiology (U.S.A.) , The Japanese Society for Matrix Biology and Medicine , The Molecular Biology Society of Japan , The Pharmaceutical Society of Japan , The Japanese Biochemical Society , Forum: Carbohydrate Coming of Age (FCCA) , The Japanese Society of Carbohydrate Research

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