Ohkubo Akihiro

オオクボアキヒロ | Ohkubo Akihiro

Affiliation and department：
Job title： Associate Professor

Research field (1)： Biochemistry

Research keywords (2)： Biological Organic Chemistry , 生物有機化学

Research theme for competitive and other funds (8)：

2016 - 2019 Development of modified U1 snRNA derivatives as new nucleic acid drugs
2012 - 2015 Development of a new method for chemical synthesis of genomic DNAs
2010 - 2011 Development of artificial aminoacylated tRNA with high efficiency of turnover
2009 - 2011 Exploration of Innovative Methods for the synthesis of RNA Capable of Machting Requirement for New day
2008 - 2009 Development of a new method for chemical synthesis of aminoacylated tRNA.

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Papers (70)：

Takashi Kanamori, Yoshiaki Masaki, Yuki Oda, Hiroki Ohzeki, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio. DNA triplex-based fluorescence turn-on sensors for adenosine using a fluorescent molecular rotor 5-(3-methylbenzofuran-2-yl) deoxyuridine. Organic and Biomolecular Chemistry. 2019. 17. 8. 2077-2080
Yoshiaki Masaki, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. Effects of 2'-O-modifications on RNA duplex stability. Synthesis of Therapeutic Oligonucleotides. 2018. 187-199
Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. Non-protected synthesis of oligonucleotides. Synthesis of Therapeutic Oligonucleotides. 2018. 3-16
Takeshi Inde, Shuhei Nishizawa, Yuusaku Hattori, Takashi Kanamori, Hideya Yuasa, Kohji Seio, Mitsuo Sekine, Akihiro Ohkubo. Synthesis of and triplex formation in oligonucleotides containing 2’-deoxy-6-thioxanthosine. Bioorganic and Medicinal Chemistry. 2018
Tanasak Kaewsomboon, Shuhei Nishizawa, Takashi Kanamori, Hideya Yuasa, Akihiro Ohkubo. pH-Dependent Switching of Base Pairs Using Artificial Nucleobases with Carboxyl Groups. J. Org. Chem. 2018. Vol. 83. No. 3. 1320-1327

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MISC (32)：

Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. Development of New Methods for Synthesis of Artificial Nucleic Acids having Various Functional Groups. JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN. 2014. 72. 8. 899-909
石井陽大, 正木慶昭, 山田剛史, 岡庭夏己, 永田哲也, 武田伸一, 金森功吏, 大窪章寛, 清尾康志, 関根光雄. 筋ジストロフィー治療を指向した塩基部修飾2′-O-MCE RNAの合成と性質. 日本化学会講演予稿集. 2014. 94th. 3
石井陽大, 正木慶昭, LIU Tianai, 田胡信広, 岡庭夏己, 山田剛史, 永田哲也, 武田伸一, 金森功吏, 大窪章寛, et al. 塩基部修飾を導入した2′-O-[2-(N-メチルカルバモイル)エチル]修飾核酸の合成とその性質. アンチセンスシンポジウム講演要旨集. 2013. 23rd
関根光雄, 正木慶昭, 山田剛史, 實吉尚郎, 岡庭夏己, 宮坂隆太, 石井陽大, 山本恵士, 大窪章寛, 清尾康志, et al. 新規2′-O-修飾RNAの開発とそのエキソン・スキッピング活性. 日本RNA学会年会要旨集. 2013. 15th
山田剛史, 岡庭夏己, 角田浩佑, 大窪章寛, 清尾康志, 関根光雄. 2′-O-[(N-メチルカルバモイル)エチル]ウリジンを組み込んだRNAオリゴマーの合成と性質. 日本化学会講演予稿集. 2011. 91st. 3

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Education (1)：

Professional career (1)：

Work history (2)：

2004 - 2004 科学技術振興機構博士研究員
2004 - Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology

Association Membership(s) (2)：

日本化学会 , 有機合成化学協会

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