Rchr
J-GLOBAL ID:200901002517715094
Update date: Dec. 18, 2024
Miyagi Yohei
ミヤギ ヨウヘイ | Miyagi Yohei
Affiliation and department:
Job title:
Director and Chief of Molecular Pathology and Genetics Division
Other affiliations (1):
Homepage URL (1):
http://kcch.kanagawa-pho.jp/kccri/organization/byoutai.html
Research field (5):
Experimental pathology
, Human pathology
, Medical biochemistry
, Cell biology
, Molecular biology
Research keywords (11):
プロテアーゼ・プロテアーゼインヒビター
, 血液凝固
, 浸潤・転移
, 遺伝子多型
, 遺伝子変異解析
, 分子腫瘍学
, Serine protease
, Proteinase inhibitor
, Blood coagulation
, Invasion and metastasis
, Molecular oncology
Research theme for competitive and other funds (55):
- 2022 - 2028 Platform of Supporting Cohort Study and Biospecimen Analysis
- 2022 - 2025 MED12野生型の子宮筋腫に対する新規治療戦略の確立
- 2022 - 2025 Pathological analysis of malignant rhabdoid tumor by utilizing the human disease model library
- 2021 - 2024 卵巣明細胞腺がんにて発現するICAM-1:アポトーシス抑制機構を含む全容の解明
- 2020 - 2023 Development of novel diagnostic markers for pancreatic cancer focused on the tumor microenvironment associated with hypoxia and nutrient depletion.
- 2019 - 2023 Development of therapeutic strategies for DDLS with CDK4 inhibitor in PDX
- 2019 - 2023 Establishment of novel drug susceptibility testing and biomarker using anaplastic thyroid cancer organoid
- 2019 - 2023 甲状腺未分化癌におけるエピジェネティクスをターゲットとした治療戦略
- 2019 - 2022 Leiomyoma therapy targeting growth effect of erythropoietin
- 2019 - 2022 Exploring the novel mechanisms of the massive growth of uterine leiomyoma by Erythropoietin
- 2020 - 2021 バイオバンクの効果的な利用に向けた品質予測法の開発
- 2018 - 2021 Effect of ectopically synthesized coagulation factor VII on venous thromboembolism and malignancy
- 2018 - 2021 胸腔系浸潤肺癌PDXのCASTIN解析によるがん幹細胞いかり分子機構の解明
- 2016 - 2021 コホート・生体試料支援プラットフォーム
- 2017 - 2020 Translational research focused on the abnormal blood coagulation system in patients with clear cell carcinoma of ovary
- 2017 - 2020 Investigation of pathophysiology and biomarker discovery for prostate cancer in the lipid-deficient hypoxia microenvironment
- 2017 - 2020 Pathological features and histogenesis of interstitial pneumonia-related lung adenocarcinoma
- 2015 - 2018 Molecular biological mechanisms of uterine leiomyoma growth.
- 2015 - 2018 Multidimensional Analysis of Cancer Stem Cell - Microenvironment Interaction with Patient Derived Xenografts (PDX) or Cancer Xenopatients
- 2014 - 2017 Exploratory study to determine predictive factors of effectiveness of paclitaxel and to establish new therapy for histone modification in anaplastic thyroid cancer.
- 2014 - 2017 Development of therapeutic strategy of poor prognostic ovarian cancer targeting ischemia-driven expression of ICAM-1
- 2014 - 2017 Roles of tumor invasion marker laminin gamma2 chain in tumor progression and cancer stem cell functions
- 2014 - 2017 Multi-dimensional interactome analyses of patient derived cancer xenograft model for personalized medicine system
- 2013 - 2016 Study to overcome the inherent chemoresistance of ovarian clear cell adenocarcinoma based on the functional analyses of ANXA4 molecular subtypes
- 2013 - 2016 Invention of novel cancer drug for refractory solid tumor
- 2013 - 2016 The basic research of preclinical simulation system for chemotherapy using "individual Cancer Xenografts"
- 2010 - 2016 Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- 2012 - 2015 Molecular biological mechanisms of tumor growth in uterine leiomyoma
- 2012 - 2015 Investigation of mechanisms to keep blood vessels patent in hepatocellular carcinoma.
- 2011 - 2013 Analysis of novel chemokine receptor variant in cancer-associated inflammatory microenvironment
- 2011 - 2013 Analysis of Sp1-dependent adaptation mechanism of cancer cells to hypoxia for tumor microenvironment-targeted therapy
- 2010 - 2012 Elucidating a determinant of development as a novel therapeutic target of ovarian clear cell adenocarcinoma
- 2010 - 2012 Fundamental research on target therapies for hormone-resistant prostate cancer
- 2009 - 2011 Coagulation factor VII producing tumors and their release of microparticles with coagulation initiating capacity
- 2008 - 前立腺癌の治療法選択に有用な分子・遺伝子診断の開発
- 2005 - 2007 ALTERNATIVE METHOD FOR THE DIAGNOSIS OF EARLY CANCER USING PLASMA FREE AMINO ACID PROFILES
- 2004 - 2007 Human kallikrein subtypes produced by gynecplogical cancer
- 2005 - 2006 molecular and pathological study on pathogenesis of cystic lung diseases : Analysis of congenital cystic adenomatoid malformation as a model.
- 2004 - 遺伝子変異・ポリモルフィズムとがんの生物学的悪性度、治療抵抗性の評価
- 1999 - 2001 Investigation for Mechanism of Cancer Metastasis Utilizing Green
- 1999 - 2000 Analysis of interaction between a novel PDZ protein and glutamate receptor δ subunit C-terminus.
- 1999 - 2000 選択的COX-2と血管新生阻害剤の時間差投与による癌再発予防
- 1999 - 2000 Study on pathogenesis of idiopathic interstitial pneumonia : Analysis of Hermansky-Pudlak syndrome as a model.
- 1998 - 2000 Study of expression of NMDA receptors molecular-biologically and the pathophysiological roles in the lung
- 1998 - 1999 簡便な遺伝子導入法を用いた遺伝子治療の基礎的研究とアレルギー性疾患治療の試み
- 1998 - 1999 Protease inhibitor PP5/TFP1-2 expression in breast cancer
- 1998 - 1999 Basic study on a gene therapy for allergic diseases
- 1998 - 1998 ウイルスベクター等を用いたグルタミン酸受容体チャネルの分子構造・生理機能解析
- 1998 - 血液凝固因子を介する癌の浸潤転移の分子機序の解明
- 1998 - Molecular mechanisms of tumor invasion and metastasis by blood coagulation factors
- 1996 - 1997 CLINICO-PATHOLOGICAL STUDY OF PEDIATRIC TUMORS
- 1996 - 1996 ヒト絨毛癌細胞におけるPP5/TFPI-2の発現制御と血行性転移における役割
- 1995 - 1996 PATHOLOGICAL AND MOLECULAR BIOLOGICAL RESEARCH ON BIOLOGICAL FEATURES OF PEDIATRIC TUMORS
- 1995 - 1995 腫瘍の浸潤・転移におけるセリンプロテアーゼインヒビターPP5/TFPI-2の役割
- 1994 - 1994 乳幼児腫瘍の自然退縮機構に関する細胞病理学及びアポトーシス関連遺伝子の研究
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Papers (278):
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Nobuyasu Suganuma, Yuka Matsubara, Akari Takahashi, Takashi Yamanaka, Toshinari Yamashita, Emi Yoshioka, Kae Kawachi, Tomonori Yokose, Hiroto Narimatsu, Daisuke Hoshino, et al. Impact of Warm Ischemia Time on HER2 Expression in Breast Cancer Surgical Specimens. Anticancer research. 2024. 44. 12. 5225-5230
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Nobuyasu Suganuma, Nao Saito, Mio Yasukawa, Takashi Yamanaka, Toshinari Yamashita, Yohei Miyagi, Aya Saito, Daisuke Hoshino. Exposure to Hypoxic Conditions Up-regulates HER2 in Breast Cancer Cell Lines. Anticancer research. 2024. 44. 12. 5187-5192
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Hirotaka Nagasaka, Shinya Sato, Atsuto Suzuki, Hideyuki Terao, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Yoichiro Okubo, Kota Washimi, Tomoyuki Yokose, Takeshi Kishida, et al. Clinicopathological Significance of Extranodal Adipose Tissue Invasion in Metastatic Lymph Nodes in Patients With Prostate Cancer. The Prostate. 2024
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Yoichiro Okubo, Nagisa Toyama, Rika Kasajima, Soji Toda, Hiroyuki Hayashi, Emi Yoshioka, Kota Washimi, Shinya Sato, Yukihiko Hiroshima, Chie Hasegawa, et al. Effective Preparation of FFPE Tissue Samples for Preserving Appropriate Nucleic Acid Quality for Genomic Analysis in Thyroid Carcinoma. Endocrine pathology. 2024
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Yuhya Hirahara, Kanako Shimizu, Satoru Yamasaki, Tomonori Iyoda, Shogo Ueda, Shinya Sato, Jotaro Harada, Haruya Saji, Satoshi Fujii, Yohei Miyagi, et al. Crucial immunological roles of the invasion front in innate and adaptive immunity in cervical cancer. British Journal of Cancer. 2024
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MISC (232):
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宮城 洋平, 室井 敦, 澤崎 達也, 太田 幸秀, 宮城 悦子, 横瀬 智之, 中村 圭靖. 新規抗がん物質PACMA5は卵巣明細胞がん細胞にpyroptosisiを誘導する(The propionic acid carbamoyl methyl amide, PACMA5, induces pyroptosis in ovarian clear cell carcinoma cells). 日本癌学会総会記事. 2022. 81回. P-1329
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宮城 洋平, 室井 敦, 澤崎 達也, 太田 幸秀, 宮城 悦子, 横瀬 智之, 中村 圭靖. 新規抗がん物質PACMA5は卵巣明細胞がん細胞にpyroptosisiを誘導する(The propionic acid carbamoyl methyl amide, PACMA5, induces pyroptosis in ovarian clear cell carcinoma cells). 日本癌学会総会記事. 2022. 81回. P-1329
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高野淳, 高野淳, 高野淳, 宮城洋平, 醍醐弥太郎, 醍醐弥太郎, 醍醐弥太郎. 肺がんの新規予後マーカー,治療標的分子URST1の同定. 日本人類遺伝学会大会プログラム・抄録集. 2022. 67th
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大島 貴, 木村 弥生, 廣島 幸彦, 大上 直秀, 横堀 武彦, 橋本 至, 渡邊 勇人, 末松 秀明, 神尾 一樹, 高橋 恒輔, et al. リキッドバイオプシーを用いたStageIII局所進行胃癌における高度リンパ節転移補助診断法の構築. 日本臨床外科学会雑誌. 2021. 82. 増刊. S620-S620
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項 慧慧, 笠島 理加, 笹田 哲朗, 宮城 洋平. 肺腺癌におけるアミノ酸代謝の新規予後予測遺伝子シグネチャーの構築. 日本癌学会総会記事. 2021. 80回. [E14-2]
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Education (4):
- - 1992 Yokohama City University Graduate Graduate School of Medicine
- - 1992 Yokohama City University Graduate School Graduate School, Division of Medicine Medical Science
- - 1986 Yokohama City University
- - 1986 Yokohama City University Faculty of Medicine
Professional career (1):
- Doctor of Medicine (Yokohama City University)
Work history (6):
- 2018/06 - 現在 Kanagawa Cancer Center Research Institute
- 2005 - Kanagawa Cancer Center, Research Institute
- 2004 - Kanagawa Cancer Center, Research Institute
- 2000 - Kanagawa Cancer Center, Research Institute
- 1999 - 横浜市立大学医学部病理学教室講師
- 1993 - 横浜市立大学医学部病理学教室助手
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Committee career (2):
- 2012/04 - 現在 日本癌学会 評議員
- 日本病理学会 学術評議員
Association Membership(s) (10):
米国癌学会
, 日本臨床検査医学会
, 日本分子生物学会
, 日本病理学会
, 日本癌学会
, The Molecular Biology Society of Japan
, The Japanese Society of Pathology
, The Japanese Cancer Association
, Japan Society of Laboratory Medicine
, American Association for Cancer Research
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