Suenaga Hikaru

Homepage URL (1)： http://www.aist.go.jp/RESEARCHERDB/cgi-bin/worker_detail.cgi?call=namae&rw_id=H72007099

Research field (1)： Applied microbiology

Research theme for competitive and other funds (7)：

2023 - 2028 Studies on innovative technology for modification of structural skeleton of natural products and production of artificial novel natural compounds
2023 - 2026 Development of innovative synthetic biology tools utilizing novel gene regulatory systems of in microorganisms
2022 - 2026 Elucidation of horizontal gene transfer mechanism and intercellular network and development of occurrence prediction system
2020 - 2024 メタゲノミクスによる海綿における天然有機化合物生産機構の解明
2019 - 2023 Fermentative production of rare natural compounds found in marine organisms living in the seas of Thailand

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Papers (64)：

Takehiro Nishimura, Kei Kudo, Miho Izumikawa, Ikuko Kozone, Junko Hashimoto, Noritaka Kagaya, Hikaru Suenaga, Koh Takeuchi, Kazuo Shin-ya. Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster. Chemical and Pharmaceutical Bulletin. 2024. 72. 5. 475-479
Kei Kudo, Takehiro Nishimura, Miho Izumikawa, Ikuko Kozone, Junko Hashimoto, Manabu Fujie, Hikaru Suenaga, Haruo Ikeda, Nori Satoh, Kazuo Shin-ya. Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds. The Journal of Antibiotics. 2024. 77. 5. 288-298
Takuya Hashimoto, Hikaru Suenaga, Keita Amagai, Junko Hashimoto, Ikuko Kozone, Shunji Takahashi, Kazuo Shin-Ya. In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq -Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont. Angewandte Chemie (International ed. in English). 2024. e202317805
Shiina Suzuki, Shun Saito, Yuki Narushima, Shunta Kodani, Noritaka Kagaya, Hikaru Suenaga, Kazuo Shin-ya, Midori A. Arai. Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation. The Journal of Antibiotics. 2023
Hidehiko Fujihara, Jun Hirose, Hikaru Suenaga. Evolution of genetic architecture and gene regulation in biphenyl/PCB-degrading bacteria. Frontiers in microbiology. 2023. 14. 1168246-1168246

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MISC (13)：

末永光. 微生物ゲノム上の反復配列の機能とその生物学的意義メタゲノム解析からひも解く微生物の環境適応戦略. 化学と生物. 2023. 61. 1
末永光. 環境メタゲノムから発見した新規な遺伝子発現調節機構の解明と生理学的意義. Institute for Fermentation, Osaka. Research Communications. 2023. 37
末永光. バイオテクノロジーの新展開遺伝子発現をコントロールする新規な合成生物学装置の開発. ケミカルエンジニヤリング. 2020. 65. 1
末永光. 新しい合成生物学装置の開発~遺伝子発現のファインチューニング~. Bio Industry. 2020. 37. 1
松沢智彦, 木村信忠, 末永光, 末永光. メタゲノムを利用した有用酵素の探索. 応用糖質科学. 2018. 8. 2

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