Uno Yasuhiro

ウノヤスヒロ | Uno Yasuhiro

Affiliation and department：
Job title： Professor

Research field (1)： Zoological sciences

Research keywords (8)：ゲノム , Veterinary Medicine , Genomics , Molecular Biology , Drug Metabolism , 分子生物学 , 獣医学 , 薬物代謝学

Research theme for competitive and other funds (4)：

2020 - 2023 Systematic identification and characterization of essential drug-metabolizing enzyme toward establishment of platform for drug metabolism research in veterinary species
2005 - 2007 Molecular mechanism of chemical-induced toxicity in fetal livers
2005 - 2006 薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらす薬物相互作用と疾病の個人差
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Papers (190)：

Yasuhiro Uno, Yuhki Minami, Kyoko Tsukiyama-Kohara, Norie Murayama, Hiroshi Yamazaki. Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity. Biochemical Pharmacology. 2024. 228
Yasuhiro Uno, Kyoko Tsukiyama-Kohara, Mayumi Ishizuka, Hazuki Mizukawa, Norie Murayama, Hiroshi Yamazaki. Investigation of Functional Cytochrome P450 4A Enzymes in Liver and Kidney of Pigs, Cats, Tree Shrews, and Dogs in Comparison with the Metabolic Capacity of Human P450 4A11. Drug Metabolism and Disposition. 2024. 52. 9. 1009-1019
Makiko Shimizu, Miaki Makiguchi, Yasuhiro Uno, Hiroshi Yamazaki. Quinuclidine N-Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs. Drug Metabolism and Disposition. 2024. 52. 8. 906-910
Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno. Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan. Drug Metabolism and Disposition. 2024. 52. 4. 305-311
Yasuhiro Uno, Miaki Makiguchi, Genki Ushirozako, Kyoko Tsukiyama-Kohara, Makiko Shimizu, Hiroshi Yamazaki. Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 2024. 277

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MISC (29)：

Yasuhiro Uno, Makiko Shimizu, Hiroshi Yamazaki. A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models. Biochemical Pharmacology. 2024. 228
田中真織, 井川佳之, 大浦華代子, 細川正清, 宇野泰広, 今井輝子. 小腸特異的に発現するサルカルボキシルエステラーゼ2の同定と基質認識特性の解析. 日本薬剤学会年会講演要旨集(Web). 2018. 33rd. 264 (WEB ONLY)
S. Uehara, Y. Uno, T. Inoue, E. Sasaki, H. Yamazaki. Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1 (vol 44, pg 8, 2016). DRUG METABOLISM AND DISPOSITION. 2017. 45. 8. 956-956
Yasuhiro Uno, Akinori Matsushita, Norie Murayama, Hiroshi Yamazaki. Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9 (vol 30, pg 130, 2015). DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 3. 192-192
Kazuhide Iwasaki, Yusuke Kitsugi, Kanami Ikeda, Takahiro Yoshikawa, Shotaro Uehara, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki. EFFECT OF CYP2C9 GENOTYPE FOR PHARMACOKINETICS OF EFAVIRENZ IN VIVO IN CYNOMOLGUS MONKEYS. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S39-S39

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Lectures and oral presentations (167)：

ヒトモデル動物での薬物体内情報を利用したヒト治療薬動態予測とモニタリング
(第51回日本毒性学会学術年会 2024)
イヌ、ブタ、カニクイザル、ツパイにおけるチトクロムP450の同定・解析
(第51回日本毒性学会学術年会 2024)
イヌ、ブタ、ツパイおよびヒトチトクロムP450 2B分子種の薬物酸化酵素活性
(日本薬学会第143年会 2023)
Identification and characterization of tree shrew CYP2Cs
(日本薬物動態学会第38回年会/第23回シトクロムP450国際会議国際合同大会 2023)
Identification and characterization of tree shrew CYP2Ds
(2023)

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Education (5)：

2008 - Hokkaido University Graduate School of Veterinary Medicine
2001 - 2003 University of Tokyo Institute of Medical Science
1998 - 2001 University of Minnesota, Molecular Veterinary Science
1994 - 1998 University of Massachusetts, Animal Science
1988 - 1994 Hokkaido University Faculty of Veterinary Medicine Department of Veterinary Medicine

Professional career (1)：

博士(獣医学) (北海道大学)

Work history (6)：

2024 - 現在 Kagoshima University Joint faculty of Veterinary Medicine Professor
2019 - 2024 Kagoshima University Joint Faculty of Veterinary Medicine Associate Professor
2017 - 2019 Shin Nippon Biomedical Laboratories, Ltd. Preclinical Research Support Division, Research Planning Unit Unit Leader
2006 - 2017 Shin Nippon Biomedical Laboratories, Ltd. Pharmacokinetics and Bionanalysis Center Unit Leader
2003 - 2006 Hokkaido University Graduate School of Pharmaceutical Science Assistant Professor

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Awards (4)：

2010 - The Japanese Society for the Study of Xenobiotics Young Investigator’s Awards
1998 - Poultry Science Association Graduate Student Research Certificate of Excellence
1998 - University of Minnesota Animal Biotechnology Center Travel Award
1994 - Yoshida Scholarship Foundation Scholarship

Association Membership(s) (2)：

THE JAPANESE SOCIETY OF VETERINARY SCIENCE , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS

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