Ito Mikako

イトウミカコ | Ito Mikako

Affiliation and department：
Job title： Lecturer

Research field (4)： Applied molecular and cellular biology , Molecular biology , Genetics , Neuroscience - general

Research theme for competitive and other funds (19)：

2020 - 2023 Pathological analysis of limb girdle congenital myasthenia and development of new therapy
2017 - 2021 Pathological analysis of GFPT1 congenital myasthenia and development of new therapy using iPS cells.
2019 - 2020 先天性筋無力症候群における分子病態の解明と新規治療法の開発
2019 - 2020 iPS 細胞を用いた先天性筋無力症候群の病態解析および新規治療法の開発
2018 - 2019 腸内細菌叢の変動によるパーキンソン病発症機序の解明と発症抑制・病態進行抑制法の開発

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Papers (96)：

Bisei Ohkawara, Hiroyuki Tomita, Taro Inoue, Shaochuan Zhang, Shunsuke Kanbara, Hiroyuki Koshimizu, Yuki Miyasaka, Jun-Ichi Takeda, Hiroshi Nishiwaki, Hiroaki Nakashima, et al. Calcitriol ameliorates motor deficits and prolongs survival of Chrne-deficient mouse, a model for congenital myasthenic syndrome, by inducing Rspo2. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024. 21. 2. e00318
Ayako Muraoka, Miho Suzuki, Tomonari Hamaguchi, Shinya Watanabe, Kenta Iijima, Yoshiteru Murofushi, Keiko Shinjo, Satoko Osuka, Yumi Hariyama, Mikako Ito, et al. Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts. Science translational medicine. 2023. 15. 700. eadd1531
Samira Bushra, Ying-Ni Lin, Atefeh Joudaki, Mikako Ito, Bisei Ohkawara, Kinji Ohno, Akio Masuda. Neural Isoforms of Agrin Are Generated by Reduced PTBP1-RNA Interaction Network Spanning the Neuron-Specific Splicing Regions in AGRN. International journal of molecular sciences. 2023. 24. 8
Shaochuan Zhang, Bisei Ohkawara, Mikako Ito, Zhizhou Huang, Fei Zhao, Tomohiko Nakata, Tomoya Takeuchi, Hidetoshi Sakurai, Hirofumi Komaki, Masayoshi Kamon, et al. A mutation in DOK7 in congenital myasthenic syndrome forms aggresome in cultured cells, and reduces DOK7 expression and MuSK phosphorylation in patient-derived iPS cells. Human Molecular Genetics. 2022
Jun Ueyama, Mai Hayashi, Masaaki Hirayama, Hiroshi Nishiwaki, Mikako Ito, Isao Saito, Yoshio Tsuboi, Tomohiko Isobe, Kinji Ohno. Effects of Pesticide Intake on Gut Microbiota and Metabolites in Healthy Adults. International journal of environmental research and public health. 2022. 20. 1

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MISC (27)：

西脇寛, 伊藤美佳子, 石田智大, 浜口知成, 前田哲也, 柏原健一, 坪井義夫, 上山純, 島村鉄平, 森宙史, et al. パーキンソン病患者の腸内細菌叢異常のメタ分析と予後因子. 腸内細菌学雑誌. 2020. 34. 2. 113-113
片岡直行, 伊藤美佳子, 増田章男, 大野欽司, 江口加代子, 伯野史彦, 高橋伸一郎, 中山恒. 低酸素条件下における選択的スプライシング機構の解明. 日本RNA学会年会要旨集. 2019. 21st
Kinji Ohno, Bisei Ohkawara, Mikako Ito. Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders. EXPERT OPINION ON THERAPEUTIC TARGETS. 2017. 21. 10. 949-958
Kinji Ohno, Bisei Ohkawara, Mikako Ito. Recent advances in congenital myasthenic syndromes. Clinical and Experimental Neuroimmunology. 2016. 7. 3. 246-259
Mikako Ito, Yumi Suzuki, Takashi Okada, Takayasu Fukudome, Toshiro Yoshimura, Akio Masuda, Shin'ichi Takeda, Eric Krejci, Kinji Ohno. PROTEIN-ANCHORING THERAPY FOR DELIVERING ACETYLCHOLINESTERASE TO THE NEUROMUSCULAR JUNCTION. JOURNAL OF GENE MEDICINE. 2014. 16. 7-8. 271-272

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Books (5)：

生物の科学遺伝 63ー5 タンパク質係留治療
エヌ・ティー・エス 2009 ISBN:4860432819
「クロモソーム植物染色体研究の方法」福井希一、向井康比己、谷口研至編著アラビドプシスにおける染色体観察方法
養賢堂 2006
細胞工学別冊植物細胞工学シリーズ13「植物細胞の分裂」シロイヌナズナ染色体の識別・同定(共著)
秀潤社 2000
植物細胞工学シリーズ13「植物細胞の分裂」町田康則、福田泰穂監修シロイヌナズナ染色体の識別・同定
秀潤社 2000
クロモソーム植物染色体研究の方法「アラビドプシスにおける染色体観察方法」
2006

Lectures and oral presentations (7)：

Protein-anchoring therapy for delivering acetylcholinesterase to the neuromuscular junction
(11th International Meeting on Cholinesterases (Poster), Kazan, Russia 2012)
Protein-anchoring therapy For delivering acetylcholinesterase to the neuromuscular junction
(17th Annual Meeting of the Japan Society of Gene Therapy (Poster), Fukuoka, Japan 2011)
分子状水素はパーキンソン病モデルラットの発症を抑制し、ヒト筋疾患の各種マーカーを改善する
(日本分子生物学会神戸ワークショップ 2010)
rAAV8-Mediated Protein-Anchoring Therapy for Targeting Collagen Q-Tailed Acetylcholinesterase to the Neuromuscular Junction
(American Society of Gene & Cell Therapy 13th Annual Meeting (Platform), Washington DC, USA 2010)
rAAV8-mediated protein anchoring of asymmetric acetylcholinesterase (AChE) to the synaptic basal lamina at the neuromuscular junction (NMJ)
(48th Annual Meeting of the American Society for Cell Biology (Poster), San Francisco, San Diego, California, USA 2008)

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Education (2)：

- 2001 Osaka University
- 2001 Osaka University Graduate School, Division of Engineering

Professional career (1)：

工学 (大阪大学)

Work history (5)：

2022/03 - 現在 Nagoya University Graduate School of Medicine Center for Neural Disease and Cancer Division Lecturer
2017/04 - 2022/03 Nagoya University Graduate School of Medicine Center for Neural Disease and Cancer Division Designated lecturer
2013/04/01 - 2017/03/31 Nagoya University Graduate School of Medicine Center for Neural Disease and Cancer Division Assistant Professor
2009/04/01 - 2013/03/31 Nagoya University Graduate School of Medicine Center for Neural Disease and Cancer Assistant Professor
2008/04/01 - 2009/03/31 Nagoya University Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Assistant Professor

Association Membership(s) (3)：

日本生化学会 , 日本筋学会 , The molecular biology society of Japan

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