2021 - 2024 Translational research using molecular form of B-type natriuretic peptide
2020 - 2023 Elucidation of transcriptional and epigenomic circuit ro reveal molecular mechanisms underlying heart failure and identify novel therapeutic targets
2019 - 2022 Development of novel diagnostic and therapeutic methods for cardiac diseases based on the elucidation of the regulatory mechanism of glycosylation of proBNP
2018 - 2021 Study of sugar chains binding to BNP precursors; 1. Structure analysis, 2. Molecular mechanism, 3. relationship with heart failure condition
2018 - 2021 Potential significance of TRPC3/6 and CNP as novel therapeutic targets of pulmonary arterial hypertension
2017 - 2020 Elucidation of transcriptional and epigenomic regulation for maintaining normal cardiac function
2017 - 2020 Translational science from rare endocrine diseases to lifestyle related diseases
2016 - 2019 Evaluation for regulatory mechanism of glycosylation and secretion of less bioactive proBNP by O-linked glycosylation
2015 - 2018 Elucidation of the molecular mechanism and clinical application of increased plasma level of BNP precursor in patients with heart failure
2014 - 2017 Elucidation of epigenetic regulation of gene expresson involved in maintaining cardiac function and metabolism
2013 - 2016 Elucidation of pathophysiological significance of glycosylation in the regulatory mechanism of BNP processing
2011 - 2014 Elucidation of transcriptional and epigenomic regulation in the development of heart failure
2011 - 2013 Translational research of circulation-regulated peptide using B-type natriuretic peptide and adrenomedullin
2010 - 2012 Elucidation of significance of TRPM2 in progression of heart failure