Research keywords (7):
Glycoprotein
, Proteasome
, Peptide:<i>N</i>-glycanase: quality control system
, 糖タンパク質
, プロテアソーム
, 品質管理機構
, ペプチド:<i>N</i>-グリカナーゼ
Research theme for competitive and other funds (5):
2018 - 2023 Clarification of novel glycan catabolic pathways by free glycan analysis of budding yeast and its application to human rare genetic disorders
2002 - 2007 糖タンパク質の品質管理における糖鎖機能の解明
2002 - 2007 Clarification of Function of Glycan Chains on Quality Control of Glycoproteins
2001 - 2004 小胞体におけるタンパク質品質管理機構に関わるPNGaseの構造と機能
2001 - 2004 Structure and Functions of PNGase Implicated in the ER Quality Control System
Papers (132):
Hiroto Hirayama, Haruhiko Fujihira, Tadashi Suzuki. Development of new NGLY1 assay systems - toward developing an early screening method for NGLY1 deficiency. Glycobiology. 2024. 34. 11
Sheng-tao Li, Tadashi Suzuki. Assay for dolichol-linked oligosaccharide: pyrophosphatase. 2021
Hiroto Hirayama, Tadashi Suzuki. Enzyme assay of endogenous activity of peptide-N-glycanase (PNGase)/N-Glycanase 1 (NGLY1) in cells and tissues using glycosylated cyclopeptide as a substrate. 2021
Sugar chains : decoding the functions of glycans
Springer 2015 ISBN:9784431553809
Education (1):
1990 - 1992 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
Professional career (2):
Master of Sciences (The University of Tokyo)
Doctor of Sciences (The University of Tokyo)
Work history (11):
2018/04 - 現在 RIKEN Glycometabolic Biochemistry Laboratory, Cluster for Pioneering Research (CPR) Chief Scientist
2017/04 - 2024/03 T-CiRA (joint research program by Takeda and the Center for iPS Cell Research and Application (CiRA), Kyoto University NGLY1 Deficiency Project Principal Investigator
2007/10 - 2018/03 RIKEN Glycometabolome Team, Systems Glycobiology Research Group Team Leader
2004/01 - 2007/09 Osaka University Graduate School of Medicine Visiting Associate Professor
2001/12 - 2005/03 Japan Science and Technology Agency Researcher, PRESTO
2002/02 - 2004/01 Undergraduate Program for Bioinformatics and Systems Biology, Graduate School of Science, University of Tokyo, Specially-appointed Assistant Professor
2000/07 - 2002/03 State University of New York at Stony Brook Research Assistant Professor
2000/04 - 2001/11 State University of New York at Stony Brook Research Scientist
1998/04 - 2000/03 Japan Society for the Promotion of Science (JSPS) Oversea Research Fellow
1997/07 - 2000/03 State University of New York at Stony Brook Postdoctoral Research Fellow,
1996/04 - 1998/03 Japan Society for the Promotion of Science (JSPS) Predoctoral Research Fellow
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Awards (12):
2023/08 - International Glycoconjugate Organization IGO Hakomori Award
2022/10 - Japanese Biochemical Society JB Reviewer Award
2016/11 - Society for Glycobiology Glycobiology Significant Achievement Award
2009/10 - Japanese Biochemical Society Samuro Kakiuchi Memorial Research Award for Young Scientists
2008/08 - Japanese Society for Carbohydrate Research Young Investigator Award
2005/10 - Japan Biochemical Society Young Investigator Award
2001/05 - International Symposium on Protein Traffic, Glycosylation, and Human Health (Interlaken) Young Scientist Award
1997/11 - Society for Glycobiology Genzyme Award
1997/09 - International Glycoconjugate Organization (GlycoXIV, Zuerich) Young Scientist Travel Award
1997/07 - Japanese Biochemical Society Travel Award for 17th IUBMB Meeting
1997 - Kato Memorial Bioscience Foundation International Exchange Fellowship
1996/02 - FCCA (Forum: Carbohydrate Coming of Age) FCCA Award for Young Researcher
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Association Membership(s) (6):
日本分子生物学会
, 日本糖質学会
, 日本生化学会
, The Molecular Biology Society of Japan
, The Japanese Society of Carbohydrate Research
, The Japanese Biochemical Society