Rchr
J-GLOBAL ID:200901004108662011   Update date: Oct. 24, 2024

Suzuki Tadashi

スズキ タダシ | Suzuki Tadashi
Affiliation and department:
Job title: Chief Scientist
Research field  (1): Functional biochemistry
Research keywords  (7): Glycoprotein ,  Proteasome ,  Peptide:<i>N</i>-glycanase: quality control system ,  糖タンパク質 ,  プロテアソーム ,  品質管理機構 ,  ペプチド:<i>N</i>-グリカナーゼ
Research theme for competitive and other funds  (5):
  • 2018 - 2023 Clarification of novel glycan catabolic pathways by free glycan analysis of budding yeast and its application to human rare genetic disorders
  • 2002 - 2007 糖タンパク質の品質管理における糖鎖機能の解明
  • 2002 - 2007 Clarification of Function of Glycan Chains on Quality Control of Glycoproteins
  • 2001 - 2004 小胞体におけるタンパク質品質管理機構に関わるPNGaseの構造と機能
  • 2001 - 2004 Structure and Functions of PNGase Implicated in the ER Quality Control System
Papers (132):
  • Hiroto Hirayama, Haruhiko Fujihira, Tadashi Suzuki. Development of new NGLY1 assay systems - toward developing an early screening method for NGLY1 deficiency. Glycobiology. 2024. 34. 11
  • Tadashi Satoh, Maho Yagi-Utsumi, Nozomi Ishii, Tsunehiro Mizushima, Hirokazu Yagi, Ryuichi Kato, Yuriko Tachida, Hiroaki Tateno, Ichiro Matsuo, Koichi Kato, et al. Structural basis of sugar recognition by SCFFBS2 ubiquitin ligase involved in NGLY1 deficiency. FEBS Letters. 2024. 598. 18. 2259-2268
  • Yukiko Yoshida, Tsuyoshi Takahashi, Nozomi Ishii, Ichiro Matsuo, Satoshi Takahashi, Haruka Inoue, Akinori Endo, Hikaru Tsuchiya, Meari Okada, Chikara Ando, et al. Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation. Molecular Cell. 2024. 84. 16. 3115-3127.e11
  • Haruhiko Fujihira, Keiko Sato, Yuji Nishiuchi, Takefumi Murase, Yuka Matsuda, Yukiko Yoshida, Takayuki Kamei, Tadashi Suzuki. ELISA-based highly sensitive assay system for the detection of endogenous NGLY1 activity. Biochemical and Biophysical Research Communications. 2024. 710. 149826-149826
  • Yukimasa Makita, Makoto Asahina, Reiko Fujinawa, Hiroshi Yukitake, Tadashi Suzuki. Intranasal oxytocin suppresses seizure-like behaviors in a mouse model of NGLY1 deficiency. Communications Biology. 2024. 7. 1. 460-460
more...
MISC (16):
  • Tadashi Suzuki, Richard D. Cummings, Markus Aebi, Armando Parodi. Glycans in Glycoprotein Quality Control. 2022. 529-538
  • Hiroto Hirayama, Tadashi Suzuki. Purification and analysis of free N-glycans in Saccharomyces cerevisiae. 2021
  • Chengcheng Huang, Tadashi Suzuki. Purification method for serum free glycans. 2021
  • Sheng-tao Li, Tadashi Suzuki. Assay for dolichol-linked oligosaccharide: pyrophosphatase. 2021
  • Hiroto Hirayama, Tadashi Suzuki. Enzyme assay of endogenous activity of peptide-N-glycanase (PNGase)/N-Glycanase 1 (NGLY1) in cells and tissues using glycosylated cyclopeptide as a substrate. 2021
more...
Books (1):
  • Sugar chains : decoding the functions of glycans
    Springer 2015 ISBN:9784431553809
Education (1):
  • 1990 - 1992 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
Professional career (2):
  • Master of Sciences (The University of Tokyo)
  • Doctor of Sciences (The University of Tokyo)
Work history (11):
  • 2018/04 - 現在 RIKEN Glycometabolic Biochemistry Laboratory, Cluster for Pioneering Research (CPR) Chief Scientist
  • 2017/04 - 2024/03 T-CiRA (joint research program by Takeda and the Center for iPS Cell Research and Application (CiRA), Kyoto University NGLY1 Deficiency Project Principal Investigator
  • 2007/10 - 2018/03 RIKEN Glycometabolome Team, Systems Glycobiology Research Group Team Leader
  • 2004/01 - 2007/09 Osaka University Graduate School of Medicine Visiting Associate Professor
  • 2001/12 - 2005/03 Japan Science and Technology Agency Researcher, PRESTO
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Awards (12):
  • 2023/08 - International Glycoconjugate Organization IGO Hakomori Award
  • 2022/10 - Japanese Biochemical Society JB Reviewer Award
  • 2016/11 - Society for Glycobiology Glycobiology Significant Achievement Award
  • 2009/10 - Japanese Biochemical Society Samuro Kakiuchi Memorial Research Award for Young Scientists
  • 2008/08 - Japanese Society for Carbohydrate Research Young Investigator Award
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Association Membership(s) (6):
日本分子生物学会 ,  日本糖質学会 ,  日本生化学会 ,  The Molecular Biology Society of Japan ,  The Japanese Society of Carbohydrate Research ,  The Japanese Biochemical Society
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