Research field (6)：
Tumor diagnostics and therapeutics
, Tumor diagnostics and therapeutics
, Medical systems
, Tumor diagnostics and therapeutics
, Nanomaterials
, Clinical pharmacy
Research keywords (7)：
Microbubble
, Liposome
, Nanotechnology
, Theranostics
, Cancer immunotheraoy
, Ultrasound
, Drug Delivery System
Research theme for competitive and other funds (27)：
2024 - 2027 Development of intra-arterial infusion therapy of immune checkpoint inhibitors using microspheres
2023 - 2027 Deletion of seizure susceptibility via transcranial deep brain stimulation
2023 - 2026 Establishment of Ultrasound Control Technique of Microbubble-Encapsulated Vesicles and Its Medical Applications
2022 - 2025 新規メンケス病治療薬創製を目指した銅錯体の体内動態および薬効の検討
2022 - 2025 Photoreaction of thioamides and its application to medicinal chemistry
2020 - 2024 Development of the integrated therapeutic strategy aiming toward drug discovery and pharmacotherapy for treatment-resistant schizophrenia
2020 - 2024 Fablication of three-dimensional tube structure with multilayer by applying active cell control using microbubbles and acoustic radiation force
2020 - 2023 Development of novel cancer therapy based on promotion of tumor infiltrating lymphocyte by the immunomodulation with ultrasound technology
2020 - 2023 Elucidation of mechanical and biological effects of oscillating microbubbles on capillary endothelial cells and extravasation
2020 - 2023 in vivo遺伝子導入による軟骨再生医療への展開
2017 - 2021 Elucidation of mechanisms and expansion of application range of sonoporation by in situ observation of bubble-cell interaction
2017 - 2020 Development of novel strategy for pancreatic cancer with ultrasound sensitive nanomedicine
2017 - 2020 Development of cell delivery system attaching flexible ultrasound array on body surface
2016 - 2019 Development of bubble preparation for ultrasound theranostics
2016 - 2019 Development of antibody delivery system by ultrasound responsive nano bubble and breast cancer treatment strategy
2015 - 2018 Development of ultrasound-responsive nanobubbles containing physiologically active gas and construction of disease treatment system
2014 - 2017 Establishment of in vivo cell delivery technique using bubble aggregation under ultrasound exposure
2014 - 2016 Development of theranostics for cancer with tumor targeted bubbles and ultrasound
2011 - 2014 Ultrasound cancer therapy in next-generation with liposomal nanobubbles having both functions of diagnostics and therapeutics
2011 - 2013 Development of drug and gene delivery into brain with ultrasound technologies
2009 - 2010 The combination therapy of mild-hyperthermia with therapeutic ultrasound and dendritic cell-based immunotherapy
2008 - 2010 Development of in vivo sonoporation method using short-pulsed ultrasound with microbubbles adjacent to cells.
2004 - 2010 腫瘍組織へのリポソームを用いて薬物デリバリー
2004 - 2010 Drug Delivery to Tumor tissue using liposome
2007 - 2009 Development of siRNA delivery system by the combination of bubble liposomes and ultrasound
2007 - 2009 cancer gene therapy using non-invasive gene delivery with Bubble liposomes and ultrasound
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Papers (262)：
Atsushi Kawai, Masahiro Noda, Haruki Hirata, Lisa Munakata, Teppei Matsuda, Daiki Omata, Naoki Takemura, Sakura Onoe, Mika Hirose, Takayuki Kato, et al. Lipid Nanoparticle with 1,2-Di-O-octadecenyl-3-trimethylammonium-propane as a Component Lipid Confers Potent Responses of Th1 Cells and Antibody against Vaccine Antigen. ACS nano. 2024. 18. 26. 16589-16609
野口彩子, 渡部舜也, 小西康太, 小川なる美, 宮本義孝, 小俣大樹, 鈴木亮, 桝田晃司. Modulation of interferential acoustic field for effective retention of vascular endothelial cells conjugated with bubbles toward elastic wall. 超音波医学 Supplement. 2024. 51
小西康太, 渡部舜也, 吉田直也, 宮本義孝, 小俣大樹, 鈴木亮, 桝田晃司. Comparison between simulation and experiment to retain vascular endothelial cells on wall surface using microbubbles and ultrasound. 超音波医学 Supplement. 2024. 51
加藤吏恵, 宗像理紗, 青枝大貴, 小山正平, 小山正平, 小俣大樹, 鈴木悠乃, 岡田欣晃, 吉岡靖雄, 吉岡靖雄, et al. Development of effective cancer immunotherapy for Cold tumor. 日本薬学会年会要旨集(Web). 2023. 143rd
