Ohta Keisuke

オオタケイスケ | Ohta Keisuke

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Kurume University

Homepage URL (1)： http://airc.kurume-u.ac.jp

Research field (6)： Cell biology , Cell biology , Nanobioscience , Morphology, anatomy , Anatomy , Neuroanatomy and physiology

Research keywords (11)： CLEM correlative light electron microscopy , Array tomography , Structual biology , 三次元解析 , SEM , mitochondria , actin bundle , electron tomography , 3D electron microscope , FIB , Histochemistry

Research theme for competitive and other funds (24)：

2022 - 2028 Advanced Bioimaging Support
2023 - 2026 Correlative observation of contact site of mitochondria and endoplasmic reticulum between light microscopy and electron microscopy
2023 - 2026 Creation of Nanomulti sensitization cascade radiotherapy against the cytoskeleton and intracellular organelles
2020 - 2023 Three dimensional ultrastructural analyses of the distribution pattern and dynamics of the interstitial cells in the connective tissues in the mammalian body.
2020 - 2023 Development of hyperthermia radiation multi-theranostics nanoparticles highly accumulated in malignant melanoma

2020 - 2023 Mitochondrial shape determination mechanism with phosphorylation and dephosphorylation process

2016 - 2019 Development of Class Lesson Model based on Learning through Discussion

2015 - 2019 The function and relationship between interstitial cells in the detrusor bundle and smooth muscle cells

2015 - 2018 Advanced 3D analysis of the stromal cells interaction and formed network following acute muscle trauma by the FIB/SEM observation.

2015 - 2018 Three dimensional ultrastructural background of mitochondrial dynamics using novel CLEM method

2015 - 2018 Observation of corneal and scleral fibroblast network by using FIB/SEM

2015 - 2018 Analysis of scars and keloids using a focused ion beam/scanning electron microscope differentiation between hypertrophic scars and keloids

2014 - 2018 Development of comprehensive mapping method of target molecule linked with cell division process

2014 - 2017 Three dimensional ultrastructural analysis of fibroblasts and their cellular network in the connective tissue by FIB/SEM tomography

2014 - 2017 Development of new cell field structure technology to elucidate the basic mechanism of eukaryotes

2013 - 2017 A new strategy for the treatment of rett syndrome with ghrelin and bone marrow transplantation

2013 - 2015 The three dimensional fine structural analysis of ICC by FIB/SEM tomography

2012 - 2015 Pathological relevance of spatial relationships between dermal macrophages and fibroblasts by new generation structome analysis

2012 - 2012 ptimization of FIB/SEM techniques ? the novel ultrastructureeanalysis by combination of serial thin ablation and block surface material contrastobservation - for biomedical mesoscale three dimentional structural analysis.

2007 - 2008 Histological and ultrastructural examination of the GFP labeled-bone marrow derived cells

2004 - 2005 細胞内シグナル伝達系遺伝子変異による新たな消化管運動障害モデルの検討

2003 - 2004 生体内で軸索末端に投与された神経栄養因子に反応する神経細胞体の同定法開発

2001 - 2002 神経栄養因子BDNFの、脊髄神経節より脊髄後索に入る突起における作用

1999 - Study of the mode of transport and the mechanisms of signal transduction of neurotrophic factors in peripheral nervous tissue

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Papers (95)：

Magdeline E. Carrasco Apolinario, Ryohei Umeda, Hitoshi Teranishi, Mengting Shan, Phurpa, Wulan Apridita Sebastian, Shaohong Lai, Nobuyuki Shimizu, Hiroshi Shiraishi, Kenshiro Shikano, et al. Behavioral and neurological effects of Vrk1 deficiency in zebrafish. Biochemical and Biophysical Research Communications. 2023. 675. 10-18
Satoko Kurata, Aya Nawata, Takuya Morinishi, Keisuke Ohta, Eisuke Katafuchi, Satoshi Hisano, Seiji Tanaka, Masanori Hisaoka, Junki Koike, Ryuta Nishikomori, et al. Immunoglobulin G deposition on proximal tubules and the tubular basement membrane in acute tubular injury complicated with focal segmental glomerulosclerosis (FSGS): A possible prediction tool for subclinical FSGS. Annals of Diagnostic Pathology. 2023. 66. 152154-152154
Mami Nomura, Keisuke Ohta, Yukinori Nishigami, Takuro Nakayama, Kei-Ichiro Nakamura, Kenjiro Tadakuma, Josephine Galipon. Three-dimensional architecture and assembly mechanism of the egg-shaped shell in testate amoeba Paulinella micropora. Frontiers in Cell and Developmental Biology. 2023. 11
Shingo Hirashima, Keisuke Ohta, Akinobu Togo, Risa Tsuneyoshi, Jingo Kusukawa, Kei-Ichiro Nakamura. Mesoscopic structural analysis via deep learning processing, with a special reference to in vitro alteration in collagen fibre induced by a gap junction inhibitor. Microscopy (Oxford, England). 2023. 72. 1. 18-26
小松誠和, 力丸由起子, 太田啓介, 原樹, 渡部功一, 安陪等思, 安永悟. 協同を基盤としたPBLの改善. 医学教育. 2022. 53. Suppl. 223-223

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MISC (52)：

Hisashi Migita, Hideaki Rikimaru, Yukiko Rikimaru-Nishi, Noriyuki Koga, Koichi Watanabe, Keisuke Ohta, Kei-Ichiro Nakamura, Kensuke Kiyokawa. Analysis of Scars and Keloids by Focused Ion Beam/Scanning Electron Microscopy: Distinguishing Between Hypertrophic Scars and Keloids. Annals of plastic surgery. 2020. 84. 4. 379-384
広重佑, 上村慶一郎, 平嶋晋吾, 都合亜記暢, 太田啓介, 太田啓介, 中村桂一郎, 井川掌. Three-dimensional ultrastructural analysis of PDGFRα-positive interstitial cells in the mammalian vas deferens by FIB/SEM tomography. 西日本泌尿器科. 2020. 82
右田尚, 力丸由起子, 古賀憲幸, 太田啓介, 中村桂一郎, 清川兼輔. ケロイドの新たな診断と治療法肥厚性瘢痕とケロイドの電子顕微鏡による三次元解析. 日本創傷治癒学会プログラム・抄録集. 2017. 47回. 102-102
太田啓介, 金澤知之進, 力丸由起子, 平嶋伸悟, 安永悟, 中村桂一郎. アクティブ・ラーニングの実践例の紹介医学部組織学実習へのLTD基盤型授業を意識した協同学習の導入とその効果. 医学教育. 2017. 48. Suppl. 13-13
鴻崎香里奈, 竹垣淳也, 田村優樹, 小林正利, 中村桂一郎, 太田啓介, 中里浩一. デュシェンヌ型筋ジストロフィーモデルラットにおける筋機能と骨格筋内ミトコンドリアの特徴. 日本筋学会学術集会プログラム・抄録集. 2017. 3回. 76-76

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Lectures and oral presentations (7)：

Imaging Technology Bridging Macro-scale to Nanometer-scale The Latest Light Electron Correlative Microscopy (CLEM)
(The 81st Annual Meeting of the Japanese Cancer Association 2022)
Micro Volume Imaging
(2022)
Practical CLEM approach using SEM
(The 78th annual meeting of the Japanese Society of Microscopy 2022)
真皮内異種間細胞性コンタクトの光電子相関(CLEM)観察
(第128回日本解剖学会全国学術集会 2022)
エポキシ樹脂準超薄切片におけるコンゴーレッド染色によるアミロイドCLEM観察
(第127回日本解剖学会全国学術集会 2022)

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Education (2)：

1991 - 1993 Kyushu Univ.
1987 - 1991 Synsyu Univ. Faculty of FIber Applied Bioscience

Professional career (2)：

Ph.,D. (Kurume University)
Master (Kyushu University)

Work history (9)：

2019/07 - 現在 Kurume University School of Medicine Deptertment of Anatomy Professor
2019/07 - 現在 Kurume University School of Medicine Advanced Imaging Research Center Professor
2018/04 - 現在 RIKEN
2017/06 - 2019/06 Kurume Univ. Sch. Med. Advanced Imaging Research Center Associate Prof.
2011/08 - 2019/06 Kurume Univ. Sch. Med. Dept. Anat. Div. Microscopic & Developmental Anatomy Associate Prof.

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Committee career (6)：

2021/04 - 現在日本電子顕微鏡学会電子顕微鏡技術認定委員長
2020/05 - 現在日本顕微鏡学会誌「顕微鏡」編集委員会委員
2017/05 - 現在日本顕微鏡学会ソフトマテリアル研究部会幹事
2014 - 現在日本顕微鏡学会技術認定委員会委員
2018/05 - 2020/05 日本顕微鏡学会将来構想委員会委員

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Association Membership(s) (3)：

日本組織細胞化学会 , 日本顕微鏡学会 , 日本解剖学会

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