2024 - 2027 Study on Biologically Active Gas Molecules Using Synthetic Heme-model Compounds
2022 - 2027 Design of transition state of the enzyme catalyzing oxidation reactions by molecules that make the enzyme malfunction
2023 - 2025 高速分子動画が明らかにする光感受性タンパク質の作用機序
2022 - 2024 Molecular movie for nitric oxide reduction at the active site of metalloenzyme
2021 - 2024 Elucidation of the chemistry of gaseous molecule at iron binuclear center using nuclear resonance spectroscopies
2022 - 2024 薬剤耐性淋菌・緑膿菌に有効な新規抗菌剤の開発
2020 - 2022 Observation of NO reduction reaction in the active site of metalloenzyme by molecular movie
2019 - 2022 Structural determination of the reaction intermediate of nitrile hydratase by XFEL and neutron beam
2019 - 2021 Characterization of a metalloenzyme producing oxygen molecule from nitric oxide
2017 - 2021 Elucidation of effective consecutive chemical reaction in cell with formation of supramolecular enzyme complex
2016 - 2019 Surface-sensitve spectro-electrochemistry on metalloenzyme electrodes
2014 - 2019 Molecular Science of NO Dyanmics in Biological System
2015 - 2018 Development of a micro-flow time-resolved IR spectrometer for analyzing short-lived reaction intermediates of enzymes
2015 - 2017 Elucidation of reaction mechanism of biological Stimuli-responsive Chemical Species by structure and electronic state observation
2009 - 2012 Molecular Evolution of Respiratory Enzymes; Functional Conversion from NO Reduction to O2 Reduction
2010 - 2011 Mechanism of catalytic nitric oxide reduction by membrane-bound nitric oxide reductase : comparison with oxygen reduction reaction
2007 - 2009 フェリチンにおける鉄と酸素の化学
2004 - 2006 共鳴ラマン分光法を用いたアレンオキサイド合成酵素の反応機構の解明
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Papers (90)：
Chai C. Gopalasingam, Haruka Egami, Hideki Shigematsu, Masatora Sakaue, Kouki Fukumoto, Christoph Gerle, Masaki Yamamoto, Yoshitsugu Shiro, Kazumasa Muramoto, Takehiko Tosha. Monomer-dimer structural comparison in quinol-dependent nitric oxide reductase reveals a functional basis for superior enzymatic activity in the dimer. 2024
Rachel Bolton, Moritz M Machelett, Jack Stubbs, Danny Axford, Nicolas Caramello, Lucrezia Catapano, Martin Malý, Matthew J Rodrigues, Charlotte Cordery, Graham J Tizzard, et al. A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 12. e2308478121
Hongjie Li, Yoshiki Nakajima, Eriko Nango, Shigeki Owada, Daichi Yamada, Kana Hashimoto, Fangjia Luo, Rie Tanaka, Fusamichi Akita, Koji Kato, et al. Oxygen-evolving photosystem II structures during S1-S2-S3 transitions. Nature. 2024. 626. 7999. 670-677
Cecilia Safari, Swagatha Ghosh, Rebecka Andersson, Jonatan Johannesson, Petra Båth, Owens Uwangue, Peter Dahl, Doris Zoric, Emil Sandelin, Adams Vallejos, et al. Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase. Science advances. 2023. 9. 49. eadh4179
Alisia Fadini, Christopher D.M. Hutchison, Dmitry Morozov, Jeffrey Chang, Karim Maghlaoui, Samuel Perrett, Fangjia Luo, Jeslyn C.X. Kho, Matthew G. Romei, R. Marc L. Morgan, et al. Serial Femtosecond Crystallography Reveals that Photoactivation in a Fluorescent Protein Proceeds via the Hula Twist Mechanism. Journal of the American Chemical Society. 2023. 145. 29. 15796-15808
GOPALASINGAM Chai, YAMAOKA Hiroaki, SHIBATA Akitoshi, FUKUMOTO Kouki, SHIGEMATSU Hideki, TOSHA Takehiko, MURAMOTO Kazumasa, SHIRO Yoshitsugu. Probing functional and structural differences of quinol dependent Nitric Oxide Reductases’ (qNOR) within a lipidic nanodisc environment. 日本蛋白質科学会年会プログラム・要旨集. 2021. 21st
吉田生未, 鳴海旭, 増田侑也, 當舎武彦, 加藤優, 加藤優, 八木一三, 八木一三. In situ observation of metalloenzymes adsorption process and construction of lipid bilayer on SAM-Au electrode. 日本表面真空学会学術講演会要旨集(Web). 2020. 2020
