Rchr
J-GLOBAL ID：200901005162981897   Update date: May. 04, 2024

Tokumitsu Hiroshi

Tokumitsu Hiroshi
Affiliation and department：
Okayama University Graduate School of Interdisciplinary Science and Engineering in Health Systems

About Okayama University Graduate School of Interdisciplinary Science and Engineering in Health Systems


Job title： Professor
Homepage URL  (1)： http://www.okayama-u.ac.jp/user/saibou/
Research field  (4)： Neuroscience - general ,  Pharmacology ,  Metabolism and endocrinology ,  Functional biochemistry
Research keywords  (34)： KN-62 ,  TIM-062 ,  TIM-063 ,  S100 protein ,  包括脳ネットワーク ,  insulin ,  glucose ,  糖尿病 ,  PREB ,  グルコース ,  インスリン ,  プロテインキナ-ゼ ,  タンパク質リン酸化酵素 ,  Numbl ,  SAD-kinase ,  タンパク質リン酸化酵素阻害剤 ,  タンパク質リン酸化反応 ,  CaM-kinase I ,  タンパク質リン酸化 ,  STO-609 ,  MLCK-A ,  Numb ,  CaMKK ,  線虫 ,  細胞内情報伝達 ,  CREB ,  CaM-キナーゼカスケード ,  リン酸化酵素カスケード ,  CaM-kinase IV ,  CaM-キナーゼ ,  シグナル伝達 ,  カルモデュリン ,  細胞内カルシウム ,  CaM-kinase kinase
Research theme for competitive and other funds  (19)：
  • 2021 - 2024 CaMKKシグナル伝達の制御機構解明とそれに基づく分子標的薬創製
  • 2019 - 2022 Regulatory mechanism of transcription by ciliary proteins.
  • 2018 - 2021 Regulation of CaMKKbeta/AMPK signaling and drug development
  • 2015 - 2019 Improvement of an animal cell-displaying technology by using a splicing factor
  • 2014 - 2017 Phosphorylation-dependent regulatory mechanism of calmoudlin-kinase cascade
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Papers (113)：
  • Akari Yoshida, Satomi Ohtsuka, Fumiya Matsumoto, Tomoyuki Miyagawa, Rei Okino, Yumeya Ikeda, Natsume Tada, Akira Gotoh, Masaki Magari, Naoya Hatano, et al. Development of a novel AAK1 inhibitor via Kinobeads-based screening. Scientific reports. 2024. 14. 1. 6723-6723
  • Satomi Ohtsuka, Yumi Miyai, Hiroyuki Mima, Masaki Magari, Yoichi Chiba, Futoshi Suizu, Hiroyuki Sakagami, Masaki Ueno, Hiroshi Tokumitsu. Transcriptional, biochemical, and immunohistochemical analyses of CaMKKβ/2 splice variants that co-localize with CaMKIV in spermatids. Cell calcium. 2024. 117. 102820-102820
  • Jason A. Kirkbride, Garbo Young Nilsson, Jee In Kim, Kosuke Takeya, Yoshinori Tanaka, Hiroshi Tokumitsu, Futoshi Suizu, Masumi Eto. PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis. Biomolecules. 2023. 13. 12. 1741-1741
  • Kento Nlandu Nakamura, Haruki Yamauchi, Hiroyuki Mima, Yerun Chen, Satomi Ohtsuka, Masaki Magari, Ryo Morishita, Hiroshi Tokumitsu. Rapid detection of calmodulin/target interaction via the proximity biotinylation method. Biochemical and biophysical research communications. 2023. 659. 29-33
  • Riku Kaneshige, Satomi Ohtsuka, Yuhei Harada, Issei Kawamata, Masaki Magari, Naoki Kanayama, Naoya Hatano, Hiroyuki Sakagami, Hiroshi Tokumitsu. Substrate recognition by Arg/Pro-rich insert domain in calcium/calmodulin-dependent protein kinase kinase for target protein kinases. The FEBS journal. 2022. 289. 19. 5971-5984
ｍore...
MISC (33)：
ｍore...
Books (2)：
  • Ca2+/calmodulin-dependent protein kinase kinase -カルシウムシグナル伝達から創薬へ-
    生化学(公益財団法人 日本生化学会) 2018
  • Ca2+/カルモデュリン依存性蛋白質リン酸化酵素カスケ-ドと生理機能
    蛋白質核酸酵素(共立出版) 1998
Professional career (1)：
  • Ph.D. (Nagoya Univ.)
Work history (11)：
  • 2021 - 現在 岡山大学 学術研究院ヘルスシステム統合科学学域 教授
  • 2018 - 現在 Okayama University Graduate School of Interdisciplinary Science and Engineering in Health Systems
  • 2012 - 2018 Okayama University Graduate School of Natural Science and Technology
  • 2007 - 2012 Kagawa University Faculty of Medicine
  • 2003 - 2007 Kagawa University Faculty of Medicine
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