Research theme for competitive and other funds (47)：
2018 - 2023 Malaria ecogenomics: Global emergence and spread of artemisinin-resistant malaria
2013 - 2016 Analysis of genetic background in a population that participated in the Phase 1b trial of BK-SE36
2013 - 2016 Genome analysis of mararia parasaite Plasmodiun gonderi
2012 - 2016 Basic research of BK-SE36 malaria vaccine clinical study
2010 - 2012 Establishment of producing method for detection antibody for primate using DNA immunization technology
2011 - 2011 Establishment of an experimental model system for a highly accelerated evolution using mutator malaria parasites generated by the disparity mutagenesis
2010 - 2011 Role of Lipocalin 2 during malaria infection
2009 - 2011 The diversity of Plasmodium SERA gene family : Adaptation of parasitism and host range
2006 - 2011 Matrix of Infection Phenomena
2008 - 2010 How P.vivax parasite maintains multiple infection in areas of low intensity malaria?
2006 - 2010 Malaria genetic diversity as a basis for parasite growth and pathogenicity
2007 - 2008 Phylogenetic analyses of Plasmodium SERA genes and the function of SERA gene families as antigen.
2007 - 2008 Mechanism of nucleic ac id-based vaccine immunogenicity
2005 - 2006 Molecular epidemiological study on the SERA antigen gene in Plasmodium falciparum
2005 - 2006 Clinical trial of SE36 malaria vaccine in the endemic area
2001 - 2006 Molecular Bases underlying Microbial Infections and the Host Responses
2001 - 2005 Basic study for the recombinant SERA malaria vaccine development
2002 - 2004 熱帯熱マラリア原虫におけるプロスタグランジン産生機構の解析
2002 - 2004 熱帯熱マラリア原虫におけるプロスタグランジン産生機構の解析
2001 - 2003 MALARIA VACCINE DEVELOPMENT BASED ON THE RECOMBINANT SERA
1999 - 2000 EPIDEMIOLOGICAL STUDY FOR DEVELOPING SERA MALARIA VACCINE
1999 - 2000 SERO-AND MOLECULAR-EPIDEMIOLOGICAL STUDY ON ECHINOCOCCOSIS AND CYSTICERCOSIS IN ASIA (2000)
1996 - 2000 Molecular approach for malaria control
1999 - 1999 マラリア制圧の総合戦略
1998 - 1999 MOLECULAR- AND IMMUNO-DIAGNOSIS FOR EMERGING/RE-EMERGING INFECTIOUS DISEASES, ECHINOCOCCOSIS AND CYSTICERCOSIS (1999)
1996 - 1999 Molecular analysis of parasitic adaptation in Malaria parasite
1997 - 1998 遺伝子鏡を用いたマラリア感染に対するDNAワクチネーションの基礎的研究
1997 - 1998 Immunodiagnosis and epidemiology of Echinococcosis/Cysticercosis in Asia
1997 - 1997 Plasmodium falciparumにおけるプロスタグランジンの機能
1996 - 1997 Development of Malaria Vaccine with Recombinant SERA Proteins
1997 - Study on host-parasite interaction of malaria infection.
1995 - 1996 Molecular-and Immuno-Biology of Echinococcosis
1993 - 1995 Development of Novel Antimalarials
1993 - 1995 Study of antigenic variation in Malaria for malaria vaccine.
1994 - 1994 Serological study on echinococcosis and cysticercosis
1991 - Development of Anti-Malarials by Computer Drug Design
1991 - Development of Malaria Vaccine
1988 - 1990 Molecular Mechanism for Initiation of DNA Replication of ColE2 and Co1E3 Plasmids
1988 - 1989 Functional domains of E.coli RecA protein for D-loop formation.
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Papers (170)：
Yusuke Hirasawa, Yusuke Kakizoe, Takahiro Tougan, Nahoko Uchiyama, Toshihiro Horii, Hiroshi Morita. Vincarostine A, a novel anti-malarial trimeric monoterpenoid indole alkaloid from Catharanthus roseus. Journal of natural medicines. 2024. 78. 3. 768-773
Nirianne Marie Q Palacpac, Ken J Ishii, Nobuko Arisue, Takahiro Tougan, Toshihiro Horii. Immune tolerance caused by repeated P. falciparum infection against SE36 malaria vaccine candidate antigen and the resulting limited polymorphism. Parasitology international. 2024. 99. 102845-102845
Issa Nebie, Nirianne Marie Q Palacpac, Edith Christiane Bougouma, Amidou Diarra, Alphonse Ouédraogo, Flavia D'Alessio, Sophie Houard, Alfred B Tiono, Simon Cousens, Toshihiro Horii, et al. Persistence of Anti-SE36 Antibodies Induced by the Malaria Vaccine Candidate BK-SE36/CpG in 5-10-Year-Old Burkinabe Children Naturally Exposed to Malaria. Vaccines. 2024. 12. 2. 166-166
Alfarius Eko Nugroho, Tomoyuki Komuro, Takuya Kawaguchi, Yusuke Shindo, Chin Piow Wong, Yusuke Hirasawa, Toshio Kaneda, Takahiro Tougan, Toshihiro Horii, A Hamid A Hadi, et al. Ceramicines U-Z from Chisocheton ceramicus and structure-antimalarial activity relationship study. Journal of natural medicines. 2024. 78. 1. 68-77
Alphonse Ouédraogo, Edith Christiane Bougouma, Nirianne Marie Q. Palacpac, Sophie Houard, Issa Nebie, Jean Sawadogo, Gloria D. Berges, Issiaka Soulama, Amidou Diarra, Denise Hien, et al. Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: a phase 1b randomised, controlled, double-blinded, age de-escalation trial. Frontiers in Immunology. 2023. 14
福田直到, BALIKAGALA Betty, 山内祐人, 牧喜子, 江本桜子, 落合紗雪, KATURO Osbert, 橘真一郎, ANYWAR Denis, PALACPAC Nirainne, et al. Sequestration and drug efficacy in falciparum malaria. 日本寄生虫学会大会プログラム・抄録集. 2020. 89th
Betty Balikagala, Miki Sakurai, Mie Ikeda, Shouki Yatsushiro, Nobuyuki Takahashi, Mary Auma, Edward H. Ntege, Daisuke Ito, Eizo Takashima, Nirianne Marie Q. Palacpac, et al. ABSENCE OF IN VIVO SELECTION OF K13 POLYMORPHISMS AFTER ARTEMETHER LUMEFANTRINE TREATMENT IN UGANDA. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017. 95. 5. 503-503
Edward H. Ntege, Nobuko Arisue, Daisuke Ito, Tomoyuki Hasegawa, Nirianne M. Q. Palacpac, Thomas G. Egwang, Toshihiro Horii, Eizo Takashima, Takafumi Tsuboi. IDENTIFICATION OF PFRIPR, AN RH5-INTERACTING PROTEIN, AS A HIGHLY CONSERVED BLOOD-STAGE MALARIA VACCINE CANDIDATE AGAINST PLASMODIUM FALCIPARUM. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017. 95. 5. 518-519
Bernard N. Kanoi, Eizo Takashima, Masayuki Morita, Edward H. Ntege, Betty Balikagala, Nirianne M. Q. Palacpac, Adoke Yeka, Thomas G. Egwang, Toshihiro Horii, Takafumi Tsuboi. ANTIBODY PROFILES TO WHEAT GERM CELL-FREE SYSTEM SYNTHESIZED PLASMODIUM FALCIPARUM PROTEINS CORRELATE WITH PROTECTION FROM SYMPTOMATIC MALARIA IN UGANDA. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017. 95. 5. 518-518
Jyotheeswara Edula Reddy, Takahiro Tougan, Toshihiro Horii. Localisation control of phosphatidylserine on infected erythrocyte membrane by malaria parasite. 2017
