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J-GLOBAL ID：200901005606477988   Update date: Nov. 18, 2024

Kato Atsushi

カトウ アツシ | Kato Atsushi
Affiliation and department：
University of Toyama Hospital, Department of Pharmacy

About University of Toyama Hospital, Department of Pharmacy


Homepage URL  (2)： https://u-toyama.elsevierpure.com/ja/persons/atsushi-kato ,  https://u-toyama.elsevierpure.com/en/persons/atsushi-kato
Research field  (4)： Pharmaceuticals - chemistry and drug development ,  Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Functional biochemistry
Research keywords  (23)： glycosidase inhibitors ,  機能性食品 ,  漢方薬 ,  chaperone ,  糖鎖プロセシング ,  和漢医薬学 ,  glycoprotein biosynthesis ,  N-linked oligossacharide ,  Pharmacological chaperone ,  小胞体品質管理機構 ,  folding disease ,  Gaucher disease ,  lysosome disease ,  glycosidase ,  sugar-mimic alkaloid ,  医療薬剤学 ,  天然物化学 ,  糖質生化学 ,  azasugar ,  iminosugar ,  Phytochemistry ,  Biochemistry ,  glycobiology
Research theme for competitive and other funds  (24)：
  • 2021 - 2024 変異酵素の構造安定化に基づく機能性シャペロン化合物の創製とポンペ病治療への応用
  • 2017 - 2020 テイ-サックス病治療に最適な高親和性シャペロン化合物の創製
  • 2016 - 2019 角質層内セラミドの増加作用を有する合成カエデタンニンの低コスト大量生産技術の開発
  • 2015 - 2018 結核菌細胞壁の構築阻害を特徴とする新規イミノ糖型治療薬のデザイン合成研究
  • 2014 - 2017 変異酵素の構造安定化剤として機能するイミノ糖型シャペロンの設計と合成
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Papers (207)：
  • Feng-Teng Gao, Ming Zhang, Yuna Shimadate, Atsushi Kato, Yi-Xian Li, Yue-Mei Jia, Chu-Yi Yu. Enantiomeric C-6 fluorinated swainsonine derivatives as highly selective and potent inhibitors of α-mannosidase and α-L-rhamnosidase: Design, synthesis and structure-activity relationship study. European Journal of Medicinal Chemistry. 2025. 282. 117031-117031
  • Feng-Teng Gao, Qing-Kun Wu, Ming Zhang, Yuna Shimadate, Gong Qian, Ying-Ying Song, Atsushi Kato, Yi-Xian Li, Yue-Mei Jia, George W.J. Fleet, et al. Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives. European Journal of Medicinal Chemistry. 2024. 275. 116570-116570
  • Yuna Shimadate, Saki Oshima, Naoto Kasamatsu, Suzuka Yamamoto, Atsumi Taguchi, Robert J. Nash, George W.J. Fleet, Takuya Okada, Naoki Toyooka, Atsushi Kato. Synthesis of 8-epi-L-swainsonine, related C6 alkylated derivatives and their α-L-rhamnosidase inhibition. Tetrahedron Letters. 2024
  • Sujit Manmode, Nazar Hussain, Oscar Javier Gamboa Marin, Atsushi Kato, José Ignacio Veytia-Bucheli, Stéphane P. Vincent, Charles Gauthier. Thioarylation of 6-Amino-2,3,6-trideoxy-d-manno-oct-2-ulosonic Acid (IminoKdo): Access to 3,6-Disubstituted Picolinates and Mechanistic Insights. Chemistry - A European Journal. 2024. 30. 12. e202303904
  • Jérôme Désiré, Zakaria Debbah, David Gueyrard, Jérôme Marrot, Yves Blériot, Atsushi Kato. Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors. Carbohydrate Research. 2023. 532. 108903-108903
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MISC (30)：
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Patents (19)：
  • セラミド調整剤
  • セラミド含量増加剤
  • 1,5-アンヒドロ-D-グルシトールの製造方法
  • インドール誘導体および血糖降下剤
  • 1,5-D-アンヒドログルシトール含有コラーゲン産生促進剤
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Books (2)：
  • Calystegine alkaloids in the potatoes and other food plants : Symposium Series No. 745/Natural and Synthetic Toxins: Biological Implications
    ACS, Washington 1999
  • Calystegine alkaloids in the potatoes and other food plants : Symposium Series No. 745/Natural and Synthetic Toxins: Biological Implications
    ACS, Washington 1999
Lectures and oral presentations  (19)：
  • Protective effects of dietary 1,5-Anhydro-D-glucitol in diabetes and metabolic syndrome.
    (2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) 2015)
  • Catalytic asymmetric syntheses and biological evaluations of α-1-C-substituted L-iminofuranose derivatives as α-glucosidase inhibitor.
    (2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) 2015)
  • In silico study on the interaction of high affinity ligand calystegine B2 with β-glucocerebrosidase.
    (2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) 2015)
  • Rare sugars as potential inducers of the rhamnose operon: Biotechnology and chemistry in the production of 6-deoxy-hexoses and related monosaccharides.
    (2015)
  • Synthesis and interactions of rhamnose iminosugar mimics with the rhamnose operon, rhamnosidases, and rhamnose isomerase.
    (2015)
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Professional career (1)：
  • Ph.D
Committee career (3)：
  • 2008 - 2010 日本病院薬剤師会 地域編集委員
  • 2007 - 和漢医薬学会 評議員
  • 2007 - Medical and Pharmaceutical Society for WAKAN-YAKU Member of the Board of Councilors
Awards (8)：
  • 2014 - 日本東洋医学会北陸支部奨励賞
  • 2012 - Tetrahedron: Asymmetry: Top-25 Most Cited Articles 2010-2011 Award (Elsevier)
  • 2009 - The Journal of Agricultural and Food Chemistry: Most active reviewers 2008-2009 Award (American Chemical Society)
  • 2009 - Bioorganic & Medicinal Chemistry: Most Cited Paper 2006-2009 Award (Elsevier)
  • 2009 - The Journal of Agricultural and Food Chemistry: Most active reviewers 2008-2009 Award (The American Chemical Society)
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Association Membership(s) (11)：
日本医療薬学会 ,  日本東洋医学会 ,  和漢医薬学会 ,  日本病院薬剤師会 ,  日本糖質学会 ,  日本薬学会 ,  Japanese Society of Pharmaceutical Health Care and Sciences ,  Medical and Pharmaceutical Society for WAKAN-YAKU ,  Japanese Society oh Hospital Pharmacists ,  The Japanese Society of Carbohydrate Research ,  The Pharmaceutical Society of Japan
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