Saito Hideyuki

2013 - 2016 Establishment of hepatocyte model from induced pluripotent stem (iPS) cells for exploring uremic toxin production inhibitors

2013 - 2016 硫酸抱合型尿毒症物質の肝合成阻害を機軸とする腎保護・尿毒症治療薬のシーズ創出

2013 - 2015 尿毒症物質産生阻害薬探索のためのヒト人工多能性幹(iPS)細胞由来肝細胞の構築

2013 - 2014 尿毒症物質の肝産生阻害を機軸とする高尿毒素血症治療薬のシーズ創出

2012 - 2013 硫酸抱合型尿毒症物質の肝産生阻害を機序とする腎障害治療薬物の効果検証

2009 - 2011 Novel strategy for development of suppressive drugs for kidney disease based on inhibition of metabolic production of uremic toxins

2009 - 2011 Development of personalized medicine for cancer chemotherapy according to a variety of sensitivity and pharmacokinetics

2007 - 2008 Development of an individualized therapy for establishing the optimal dosage by analysis of pharmacological gene

2005 - 2008 Strategy for protection of kidney injury based on functioal relation betwee renal specific stress response mechanisms and xenobiotic detoxication systems

2007 - 腎不全・尿毒症の病態進展因子の解明を基盤とした治療薬探索

2007 - Exploration of therabeutic drugs for renal diseases and uremia

2005 - 2006 Development of dosage individualization of anti-tumor drugs based on therapeutic drug monitoring and pharmacokinetic-related gene expression

2002 - 2004 Molecular Biological Studies on Relationships between Changes in Renal Tubular Transporter Gene Expressions and Deterioration of Drug Excretory Functions in Renal Diseases

2002 - 2003 薬物トランスポータの発現量変動評価系の構築-薬物体内動態制御薬の開発へ向けて

2001 - 2003 Evaluation of drug interaction and interindividual differences of renal drug excretion based on the genetic polymorphism analysis

2000 - 2001 MOLECULAR ANALYSIS OF CORRELATION BEIWEEN ALTERATIONS IN XENOBIOTIC TRANSPORTER EXPRESSIONS AND ATTENUATED DRUG EXCRETION IN RENAL FAILURE

2000 - 2000 薬物トランスポータの分子認識能に基づく薬物分子設計

1999 - 2000 Molecular diversity of organic ion transporters and their roles in the renal drug excretion

1999 - 1999 薬物トランスポータ分子認識を利用した薬物動態制御システムの構築

1997 - 1999 Development of novel systems for evaluation and prediction of drug inteactions based on the reconstruction of drug excretion systems in vitro.

1997 - 1998 ペプチドトランスポータ遺伝子導入安定発現系の確立に基づく薬物認識機構の分子的解明

1997 - 1997 薬剤性腎障害発現におけるアポトーシスの役割に関する研究

1996 - 1997 Molucular analysis of tissue distribution and structure-function relationship of transporters responsible for the regulation of drug transport

1996 - 1996 プロトン駆動型ペプチド輸送体の臓器分布特性と基算認識機構に関する分子生物学的解析

1995 - 1996 Kietic analysis and evaluation of drug absorption and excretion using cultured cells.

1995 - 1995 PCR法及び外来遺伝子発現系による薬物トランスポータ群の構造・機能解析

1994 - 1995 Molecular and Cell Biological Analyzes of Structure and Function of Drug Transporters in the Intestine and Kidney Proximal Tubule

1993 - 1993 小腸及び腎尿細管上皮細胞における薬物輸送体の分子生物学的研究

1992 - 1992 小腸及び腎尿細管におけるプロトン共役薬物輸送担体の発現と調節

1992 - 1992 小腸及び腎尿細管上皮細胞における薬物輸送担体の構造と機能に関する研究

1992 - 1992 アフリカツメガエル卵母細胞による外来遺伝子発現系を用いた薬物輸送担体の構造解析

1991 - 1992 The Use of Cultured Cells for Alternatives to Animal Experiments in Drag Absorption and Secretion

1990 - 1991 Structure and Function of Drug Transporters in the Intestinal and Renal Epithelial Cells

1989 - 1990 In Vitro New Evaluation Method for the Drug Absorption and Secretion Using Membrane Vesicles