2017 - 2021 Search for uremia suppressive therapeutics based on investigation on role of sulfate-conjugated uremic solutes in development and pregoression of kidney injury
2016 - 2020 硫酸抱合型尿毒症物質の産生阻害による腎障害治療薬の探索
2013 - 2017 Development of renoprotective and uremia therapeutic drug seeds based on inhibition of hepatic production of sulfate-conjugated uremic solutes
2013 - 2016 Establishment of hepatocyte model from induced pluripotent stem (iPS) cells for exploring uremic toxin production inhibitors
2009 - 2011 Novel strategy for development of suppressive drugs for kidney disease based on inhibition of metabolic production of uremic toxins
2009 - 2011 Development of personalized medicine for cancer chemotherapy according to a variety of sensitivity and pharmacokinetics
2007 - 2008 Development of an individualized therapy for establishing the optimal dosage by analysis of pharmacological gene
2005 - 2008 Strategy for protection of kidney injury based on functioal relation betwee renal specific stress response mechanisms and xenobiotic detoxication systems
2007 - 腎不全・尿毒症の病態進展因子の解明を基盤とした治療薬探索
2007 - Exploration of therabeutic drugs for renal diseases and uremia
2005 - 2006 Development of dosage individualization of anti-tumor drugs based on therapeutic drug monitoring and pharmacokinetic-related gene expression
2002 - 2004 Molecular Biological Studies on Relationships between Changes in Renal Tubular Transporter Gene Expressions and Deterioration of Drug Excretory Functions in Renal Diseases
2001 - 2003 Evaluation of drug interaction and interindividual differences of renal drug excretion based on the genetic polymorphism analysis
2000 - 2001 MOLECULAR ANALYSIS OF CORRELATION BEIWEEN ALTERATIONS IN XENOBIOTIC TRANSPORTER EXPRESSIONS AND ATTENUATED DRUG EXCRETION IN RENAL FAILURE
2000 - 2000 薬物トランスポータの分子認識能に基づく薬物分子設計
1999 - 2000 Molecular diversity of organic ion transporters and their roles in the renal drug excretion
1999 - 1999 薬物トランスポータ分子認識を利用した薬物動態制御システムの構築
1997 - 1999 Development of novel systems for evaluation and prediction of drug inteactions based on the reconstruction of drug excretion systems in vitro.
1996 - 1997 Molucular analysis of tissue distribution and structure-function relationship of transporters responsible for the regulation of drug transport
1991 - 1992 The Use of Cultured Cells for Alternatives to Animal Experiments in Drag Absorption and Secretion
1990 - 1991 Structure and Function of Drug Transporters in the Intestinal and Renal Epithelial Cells
1989 - 1990 In Vitro New Evaluation Method for the Drug Absorption and Secretion Using Membrane Vesicles
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Papers (249)：
Kazutaka Oda, Kazuaki Matsumoto, Kensuke Shoji, Akari Shigemi, Hideki Kawamura, Yoshiko Takahashi, Tomomi Katanoda, Yumi Hashiguchi, Hirofumi Jono, Hideyuki Saito, et al. Validation and development of population pharmacokinetic model of vancomycin using a real-world database from a nationwide free web application. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2024
Kazutaka Oda, Hirofumi Jono, Hidenobu Kamohara, Hideyuki Saito. Population Pharmacokinetic Modeling of Unbound Meropenem in Patients Undergoing Continuous Renal Replacement Therapy: An Observational Cohort Study. Therapeutic drug monitoring. 2024
Kazutaka Oda, Tomoyuki Yamada, Kazuaki Matsumoto, Yuki Hanai, Takashi Ueda, Masaru Samura, Akari Shigemi, Hirofumi Jono, Hideyuki Saito, Toshimi Kimura. Model-informed precision dosing of vancomycin for rapid achievement of target area under the concentration-time curve: A simulation study. Clinical and translational science. 2023. 16. 11. 2265-2275
Ayumi Kanemaru, Yuki Ito, Michiko Yamaoka, Yuki Shirakawa, Kou Yonemaru, Shunsuke Miyake, Misaki Ando, Masako Ota, Takeshi Masuda, Akitake Mukasa, et al. Wnt/β-catenin signaling is a novel therapeutic target for tumor suppressor CYLD-silenced glioblastoma cells. Oncology Reports. 2023. 50. 5
Kazutaka Oda, Ayami Yamaguchi, Naoya Matsumoto, Hirotomo Nakata, Yusuke Higuchi, Kisato Nosaka, Hirofumi Jono, Hideyuki Saito. Dose Individualization of Cefepime for Febrile Neutropenia in Patients With Lymphoma or Multiple Myeloma: Implications for Therapeutic Drug Monitoring. Therapeutic drug monitoring. 2023
HOU Huixian, HORIKAWA Mai, NARITA Yuki, JONO Hirofumi, SAITO Hideyuki. Unilateral ureteral obstruction (UUO)-induced renal fibrosis is attenuated by suppression of indoxyl sulfate (IS) accumulation in sulfotransferase (Sult) 1a1-deficient mice. 日本腎臓学会誌(Web). 2023. 65. 3
新垣ひとみ, 桑野明香里, 平井ちか, 西郷智香, 金丸歩美, 林光博, 齋藤秀之, 齋藤秀之, 成田勇樹, 成田勇樹, et al. Novel drug therapy targeting NF-kB signal for triple-negative breast cancer patients with loss of CYLD expression. 日本薬学会年会要旨集(Web). 2023. 143rd
松山果穂, 三宅俊介, 三宅俊介, 下村祐美, 金丸歩美, 西郷智香, 成田勇樹, 成田勇樹, 本岡大社, 岩越裕, et al. Clinical significance and development of novel therapies for advanced ovarian cancer with loss of tumor suppressor gene CYLD expression. 日本薬学会年会要旨集(Web). 2023. 143rd
日本緩和医療薬学会
, 日本臨床薬理学会
, THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN
, 国際TDM学会
, 日本TDM学会
, JAPANESE SOCIETY OF NEPHROLOGY
, THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
, JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, 米国腎臓学会
, American Association of Pharmaceutical Scientists
