Rchr
J-GLOBAL ID：200901005964997640   Update date: Apr. 12, 2023

Hirose Akihiko

ヒロセ アキヒコ | Hirose Akihiko
Affiliation and department：
Chemicals Evaluation and Research Institute, Japan Chemical Assessment and Research Center

About Chemicals Evaluation and Research Institute, Japan Chemical Assessment and Research Center


Job title： Science Advisor
Homepage URL  (1)： https://www.cerij.or.jp/index.html
Research field  (11)： Healthcare management, medical sociology ,  Hygiene and public health (non-laboratory) ,  Hygiene and public health (laboratory) ,  Hygiene and public health (non-laboratory) ,  Hygiene and public health (laboratory) ,  Healthcare management, medical sociology ,  Pharmaceuticals - health and biochemistry ,  Nanobioscience ,  Nanomaterials ,  Environmental effects of chemicals ,  Environmental effects of radiation
Research keywords  (4)： 安全性評価 ,  毒性学 ,  Safety Risk Assessment ,  Toxicology
Research theme for competitive and other funds  (39)：
  • 2018 - 2020 cfDNAおよびエクソソームRNAをバイオマーカーとした医薬品の次世代毒性評価法の開発
  • 2018 - 2020 医薬品の安全性及び品質確保のための医薬品規制に係る国際調和の推進に関する研究
  • 2018 - 2020 血液中の核酸をバイオマーカーに用いた化学物質の高感度な有害性評価に資する研究
  • 2018 - 2020 インシリコ予測技術の高度化・実用化に基づく化学物質のヒト健康リスクの評価ストラテジーの開発
  • 2018 - 2020 ナノマテリアル曝露による慢性影響の効果的評価手法開発に関する研究
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Papers (167)：
  • Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Edward J. Perkins, Hiroshi Yokozaki, Hiroki Sasaki. Regulation of Epithelial-Mesenchymal Transition Pathway and Artificial Intelligence-Based Modeling for Pathway Activity Prediction. Onco. 2023. 3. 1. 13-25
  • Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi, et al. Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats. Particle and Fibre Toxicology. 2022. 19. 1
  • Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki. Molecular network analysis of RNA viral infection pathway in diffuse- and intestinal-type gastric cancer. Fundamental Toxicological Sciences. 2022. 9. 2. 37-46
  • Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki. Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer. Cancers. 2021. 13. 22. 5786-5786
  • Shihori Tanabe, Akihiko Hirose, Takashi Yamada. Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy. OECD Series on Adverse Outcome Pathways. 2021. 17
ｍore...
MISC (80)：
  • Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki. Molecular network profiling in mesenchymal stem cells, diffuse- and intestinal-type gastric cancer. CANCER SCIENCE. 2021. 112. 592-592
  • 石井 明子, 橋井 則貴, 松本 真理子, 香取 典子, 新井 進, 粟津 洋寿, 磯野 哲也, 井上 友美, 永座 明, 大山 幸仁, et al. シングルユースシステムを用いて製造されるバイオ医薬品の品質確保に関する提言. 日本PDA学術誌GMPとバリデーション. 2017. 19. 2. 15-29
  • 津田 洋幸, 徐 結苟, Alexander William T, Alexander David B, Abdelgied Mohamed Ahmed Mahmoud, El-Gazzar Ahmed Maher Mahmoud, 沼野 琢旬, 酒々井 眞澄, 二口 充, 深町 勝巳, et al. カーボンナノチューブの「剛性」と発がん性 アスベストとの比較 気管内噴霧投与法による各種のMWCNTの毒性と発がん性試験結果の比較. The Journal of Toxicological Sciences. 2017. 42. Suppl. S26-S26
  • H. Tsuda, D. B. Alexander, W. T. Alexander, M. Abd Elgied, A. Elgazzar, J. Xu, T. Numano, M. Suzui, M. Futakuchi, K. Fukamachi, et al. Development of a mechanism based short-term assay protocol to test carcinogenicity of multiple wall carbon nanotubes (MWNCTs) in the rat. TOXICOLOGY LETTERS. 2016. 259. S22-S22
  • A. Ono, H. Jinno, A. Hirose. Evaluation of the OECD QSAR toolbox in the screening of chemical sensitizer. TOXICOLOGY LETTERS. 2016. 259. S228-S228
ｍore...
Books (1)：
  • 「4.リスクアセスメント・リスクマネージメント」、[新版]トキシコロジー、
    朝倉書店 2009 ISBN:9784254340259
Education (4)：
  • - 1990 Tohoku University
  • - 1990 Tohoku University Graduate School, Division of Medicine
  • - 1984 Toyama Medical and Pharmaceutical University
  • - 1984 Toyama Medical and Pharmaceutical University Faculty of Pharmaceutical Science
Work history (8)：
  • 2022/06 - 現在 Chemicals Evaluation and Research Institute, Japan Chemical Assessment and Research Center Science Advisor
  • 2022/04 - 現在 National Institute of Health Sciences Division of Risk Assessment Visiting Researcher
  • 2015/04 - 2022/03 国立医薬品食品衛生研究所 安全性予測評価部 部長
  • 2008 - :国立医薬品食品衛生研究所総合評価研究室室長
  • 1996 - :国立医薬品食品衛生研究所総合評価研究室主任研究官
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Committee career (1)：
  • 2002 - The Japanese Society of Toxicology Councilor
Awards (1)：
  • 2021/07 - Japanese Society of Toxicology The JSOT Award
Association Membership(s) (4)：
Society of Toxicology ,  日本内分泌撹乱化学物質学会 ,  日本食品化学学会 ,  日本毒性学会
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