2018 - 2022 Identification of Parkinson's disease progression markers based on skeletal muscle-brain axis
2020 - 2022 Development of technology to keep transplanted cells healthy by elucidating α-synuclein propagation mechanisms in the cell transplantation therapy for Parkinson's disease
2018 - 2021 Identification of Parkinson disease-specific mitochondrial pathogenesis for disease-modifying therapy
2018 - 2021 Research on PD pathogenesis based on polyamine metabolism using multiomics analysis
2018 - 2021 Exploration of the process of exosome generation which reduce alpha synuclein accumulation and development of novel PD therapy
2018 - 2021 てんかん原因遺伝子の網羅的解析および心電図の診断有用性の検討
2017 - 2020 Elucidation of mechanism of sleep bruxism: a high-throughput assay to detect electrophysiological dysfunction using patient-specific iPSCs
2017 - 2020 Restoration of inner ear gap junction with iPS derived model cell and genome editing
2017 - 2020 神経疾患特異的iPS細胞を活用した病態解明と新規治療法の創出を目指した研究
2017 - 2020 ニーマン・ピック病C型の病態解明と革新的治療薬の開発に関する研究
2017 - 2020 ゾニサミドの抗パーキンソン病薬作用機構の解明
2017 - 2020 疾患iPS 細胞を用いた遺伝性・孤発性パーキンソン病の新規治療薬探索
2017 - 2019 疾患iPS細胞を用いた脳タンパク質老化モデルの構築と治療薬の開発
2016 - 2019 Development of novel cellular models for Parkinson's disease focusing on energy-homeostasis
2016 - 2019 iPSC-based disease modeling of sporadic Parkinson's disease
2015 - 2019 Brain Protein Aging and Dementia Control(International Research Activities Supporting Program)
2017 - 2019 疾患iPS細胞を用いた脳タンパク質老化モデルの構築と治療薬の開発
2017 - 2019 iPS細胞を用いた孤発性パーキンソン病の再分類と創薬
2015 - 2018 Development of anti-PD chemicals modulating autophagic activity based on lysosomal function
2014 - 2018 Development of disease-modifying drugs for sleep bruxism using iPS cell
2014 - 2018 Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene products
2012 - 2015 The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa
2011 - 2014 皮膚から直接誘導した神経幹細胞の移植治療効果と安全性の検討
2011 - 2013 Safety and effectiveness of neural stem cells directly induced from skin fibroblasts
2011 - 2012 Analysis of iPS cells from patients with 22q11.2 deletion and schizophrenia
2008 - 2011 腫瘍発生のリスクのない多能性幹細胞移植治療の開発の基礎的研究
2008 - 2010 Establishment of iPS cell transplantation that does not form teratomas
2002 - 2004 神経特異的RNA結合蛋白質による正常神経発生および腫瘍発生の制御機構の解明
2002 - 2003 The Role of RNA Binding Protein Hu in pathophysiology of the paraneoplastic neurologic disorders (PND's)
2002 - 2003 神経特異的RNA結合蛋白質による正常神経発生および腫瘍発生の制御機構の解明
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Papers (126)：
Daisuke Arai, Mikako Takahashi-Shibata, Takao Ukaji, Harumi Tsutsumi, Shori Tajima, Shin-Ya Nishio, Kei-Ichi Ishikawa, Wado Akamatsu, Fumihiko Matsumoto, Katsuhisa Ikeda, et al. Generation of an induced pluripotent stem cell line from a late-onset, progressive high frequency hearing loss patient due to mutation in CDH23. Stem cell research. 2024. 79. 103471-103471
Xing Liu, Kei-Ichi Ishikawa, Nobutaka Hattori, Wado Akamatsu. Generation of one induced pluripotent stem cell line JUCGRMi004-A from a Charcot-Marie-Tooth disease type 1A (CMT1A) patient with PMP22 duplication. Stem cell research. 2024. 77. 103401-103401
Kei-Ichi Ishikawa, Ayami Okuzumi, Hiroyo Yoshino, Nobutaka Hattori, Wado Akamatsu. Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson's disease with PARK2 mutation. Stem cell research. 2024. 76. 103323-103323
Kei-Ichi Ishikawa, Takahiro Shiga, Manabu Funayama, Nobutaka Hattori, Wado Akamatsu. Generation of a control iPS cell line (JUCGRMi006-A) with no abnormalities in Parkinson's disease-related genes. Stem cell research. 2024. 74. 103270-103270
Kei-Ichi Ishikawa, Takahiro Shiga, Manabu Funayama, Nobutaka Hattori, Wado Akamatsu. Generation of a control iPS cell line (JUCGRMi005-A) with no abnormalities in Parkinson's disease-related genes. Stem cell research. 2024. 74. 103271-103271
Increased excitability of human iPSC-derived neurons in HTR2A variant-related sleep bruxism.
(Stem cell research 2022)
In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells
(Scientific Reports 2021)
Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons
(Neurochemistry International 2021)
Generation of two iPSC lines from siblings of a homozygous patient with hearing loss and a heterozygous carrier with normal hearing carrying p.G45E/Y136X mutation in GJB2.
(Stem cell research 2021)
international society for stem cell research
, THE JAPAN NEUROSCIENCE SOCIETY
, JAPAN PEDIATRIC SOCIETY
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
