MARUYAMA TAKASHI

Homepage URL (1)： https://app.jove.com/methods-collections/1067/current-methods-in-intestinal-homeostasis-research

Research field (2)： Allergies and connective tissue disease , Immunology

Research keywords (3)： IκB-ζ , Gene rergulation , Immunology

Research theme for competitive and other funds (12)：

2018 - 2023 Association between pathogenic Th17 in periodontal disease and rheumatoid arthritis onsets.
2016 - 2019 Biological regulation by Galpha12/13-mediated lipid mediator function
2015 - 2017 シェーグレン症候群を引き起こす自己応答性T細胞の探索
2014 - 2016 Molecular mechanisms of Nuclear IkappaB family proteins control immune maturation.
2016 - プロポリス成分による自己免疫疾患の治療と予防効果の検証

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Papers (48)：

Jian Gu, Xiaozhang Xu, Xiangyu Li, Lei Yue, Xiaowen Zhu, Qiuyang Chen, Ji Gao, Maruyama Takashi, Wenhu Zhao, Bo Zhao, et al. Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation. Oncogene. 2024
Naoya Taki, Atsushi Kimura, Yasuyuki Shiraishi, Takashi Maruyama, Tsukasa Ohmori, Katsushi Takeshita. Conditional deletion of IκBζ in hematopoietic cells promotes functional recovery after spinal cord injury in mice. J Orthop Sci. 2024. S0949-2658(24)00088-5
Takashi MaruYama, Hirofumi Miyazaki, Taishi Komori, Shion Osana, Hiroyuki Shibata, Yuji Owada, Shuhei Kobayashi. Curcumin analog GO-Y030 inhibits tumor metastasis and glycolysis. The Journal of Biochemistry. 2023. 174. 6. 511-518
MaruYama T, Miyazaki H, Lim YJ, Gu J, Ishikawa M, Yoshida T, Chen W, Owada Y, Shibata H. Pyrolyzed Deketene Curcumin Controls Regulatory T Cell Generation and Gastric Cancer Metabolism Cooperate With 2-Deoxy-D-Glucose. Frontiers in Immunology (T Cell Biology). 2023. 14. 1049713
Tomohiko Murakami, Yoshifumi Takahata, Kenji Hata, Kosuke Ebina, Katsutoshi Hirose, Lerdluck Ruengsinpinya, Yuri Nakaminami, Yuki Etani, Sachi Kobayashi, Takashi Maruyama, et al. Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. Science Signaling. 2022. 15. 758. eabl5304

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MISC (9)：

丸山貴司, 宮崎啓史, 大和田祐二. 関節リウマチにおける慢性炎症の制御. BIO Clinica 2024年 2月号膠原病診療と分子標的薬 update 第39巻第2号. 2024. 160-162
丸山貴司. 転写因子IκB-ζを介した関節リウマチの慢性化. 膠原病(別冊 BIO Clinica 慢性炎症と疾患通巻31号第12巻第2巻). 2023. 81-83
Takashi MaruYama, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Shibata. Mono-Carbonyl Curcumin Analogs for Cancer Therapy. Biological and Pharmaceutical Bulletin. 2023. 46. 6. 756-763
MaruYama T, Chen W, Shibata H. TGF-β and Cancer Immunotherapy. Biol. Pharm. Bull 【Featured Article】. 2022. 45. 2. 155-161
Takashi MaruYama. The nuclear I kappa B family of proteins controls gene regulation and immune homeostasis. INTERNATIONAL IMMUNOPHARMACOLOGY. 2015. 28. 2. 836-840

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Patents (1)：

Books (1)：

IkappaB (pp.2600-2604)
Encyclopedia of Signaling Molecules, 2nd Edition (Springer) 2016

Lectures and oral presentations (41)：

糖代謝とTh17細胞 (幕張メッセ)
(APPW2025 (Symposium) 2025)
クルクミンアナログGO-Y022を介した炎症制御機構の解明(T-12, 一般口頭発表)
(2024年度日本生化学会関東支部例会(東京) 2024)
高病原性Th17細胞の実態解明 (口頭発表)
(第32回東京免疫フォーラム(東京大学医科学研究所1号棟) 2024)
クルクミンアナログを用いた炎症制御機構(2OamE-09)(口頭発表)
(第129回日本解剖学会総会(沖縄なはーと) 2024)
British Journal of Pharmacology (Reviewer Certificate)

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Professional career (2)：

博士(薬学)甲第192号接触性皮膚炎モデルの感作過程におけるフタル酸エステルのアジュバント作用とTRP受容体を介した神経刺激作用の関係2007年3月23日 (静岡県立大学)
修士(理学)PCRを用いたウシ乳汁中細菌の迅速同定法の確立および乳房炎診断への応用生命修第87号・2004年3月20日

Work history (16)：

2022/04 - 2025/03 千葉大学薬学研究科客員准教授
2024/04 - 東北大学未踏スケールデータアナリティクスセンター客員研究員
2021/10 - 2024/03 東北大学医学系研究科非常勤講師
2020/01 - 2023/12 National Institute of Health (United States of America): Staff Scientist (non-tenure)
2019/07 - 2020/03 Tohoku University Graduate School of Medicine (Japan); Visiting Researcher

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Committee career (4)：

2021/02 - 現在 Frontiers in Immunology (T cell Biology) Associate Editor
2023/01 - 2023/06 IRP Recruiter Academy (NIH, NIH Virtual Scientific Recruitment Summit)
2020/06 - 2021/02 Frontiers in Immunology (T cell Biology) Review Editor
2017/07 - 2020/01 Akita Igaku (Akita University, Schoolf of Medicine, Japan) Board Member

Awards (11)：

2024/03 - 東京免疫フォーラム東京免疫フォーラム研究奨励賞(2024.03.26)
2018/05 - Encouraging Research Award from Japanese Biochemical Society (Tohoku Branch), Japan
2017/11 - Akita Wakasugi Science and Technology Encouragement Award (Japan)
2016/06 - Novo Nordisk International Travel Bursary for the 16th ICI (International Congress of Immunology)
2015/07 - The Federation of Immunological Societies of Asia-Oceania (FIMSA) 6th Congress in Singapore (Travel Fellowship)

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