Research theme for competitive and other funds (39)：
2022 - 2027 Identification of self-derived molecules recognized by immune sensors
2022 - 2027 Self-referential immune perception
2020 - 2023 全ての患者に適応可能な代謝産物を標的とする革新的がん免疫療法の開発
2020 - 2023 レクチン受容体を介する自己認識の生物学的意義と分子基盤
2019 - 2022 Exploration of Self-Assembling Bioactive Small Molecules
2017 - 2020 Molecular basis for the evasion of host immunity by mycobacteria
2015 - 2019 Establishment of international research community on cell death
2014 - 2019 Identification of endogenous glycolipids that activate immune responses via lectin receptors
2014 - 2019 Homeostatic regulation by various type of cell death
2015 - 2018 Molecular mechanism of adipose tissue inflammation through Mincle and cell-cell interactions
2015 - 2018 Development of a new therapy through the clarification of innate immune receptor for PAMPs in children with vasculitis
2015 - 2018 Roles of receptors for damage-associated molecular patterns on neuropathic pain
2015 - 2018 Regulation of innate immune response to mycobacteria through the recognition of immunoregulating cell wall lipids by ITAM-coupled receptors
2014 - 2017 Retinal regeneration due to regulation of natural immunity
2014 - 2017 Regulation of immune responses via C-type lectin receptor family that recognize mycobacteria
2014 - 2015 Analyses on the heterodimer formation between different C-type lectin receptors
2012 - 2015 Roles of a newly identified pattern-recognition receptor family which activate innate immunity in development of neuropathic pain.
2012 - 2015 Role for novel innate immune receptors for pulmonary pathogens
2013 - 2014 Molecular mechanism of tissue fibrosis and develpment of revolutionary anti-fibrotic therapy
2009 - 2013 レクチン受容体による生体の危機管理機構の解明
2011 - 2012 Role of a novel pathogen sensor in the pathophysiology of acute renal failure
2010 - 2011 Mincleによる内因性リガンド認識とその破綻に伴う炎症性疾患の解明
2010 - 2011 レクチン受容体を介する自己・非自己認識機構とその意義の解明
2008 - 2009 プレT細胞受容体を介するT細胞分化機構の解析
2006 - 2007 プレTCRを介するリガンド非依存的シグナルの分子機構
2004 - 2005 抑制性アダプターGab2によるTCRシグナル制御のinvivoにおける役割
2002 - 2003 Scaffold分子Gab2によるTCRシグナル抑制機構の解析
2001 - 2002 Regulatory mechanism of T cell development by pre-T cell specific transcription factors
2001 - 2001 プロモータートラップを用いたT細胞活性化に伴って誘導される遺伝子の検索
2001 - 2001 トランスジェニックマウスを用いたHIV特異的キラーT細胞の認識と機能の解析
2000 - 2001 スーパー抗原に特異的なT細胞活性化シグナルの解析
2000 - 2001 Development of a new approach for immunosuppression on the basis of expression regulation of CTLA-4
2000 - 2000 プロモータートラップを用いたT細胞活性化に伴って誘導される遺伝子の検索
2000 - 2000 トランスジェニックマウスを用いたHIV特異的キラーT細胞の認識と機能の解析
1999 - 2000 Elucidation of mechanism of NK cell activation
1998 - 2000 Signal transduction regulating the differentiation and the function of T cells
1999 - 1999 トランスジェニックマウスを用いたHIV特異的キラーT細胞の認識と機能解析
1997 - 1999 抗腫瘍免疫におけるT細胞活性化の抑制
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Papers (234)：
Yuki Hosono, Noriyuki Tomiyasu, Hayato Kasai, Eri Ishikawa, Masatomo Takahashi, Akihiro Imamura, Hideharu Ishida, Federica Compostella, Hiroshi Kida, Atsushi Kumanogoh, et al. Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells. The Journal of experimental medicine. 2025. 222. 2
Yuki Sakai, Minori Asa, Mika Hirose, Wakana Kusuhara, Nagatoshi Fujiwara, Hiroto Tamashima, Takahiro Ikazaki, Shiori Oka, Kota Kuraba, Kentaro Tanaka, et al. A conserved human CD4+ T cell subset recognizing the mycobacterial adjuvant, trehalose monomycolate. The Journal of clinical investigation. 2024
Yukiko Takeuchi, Eri Ishikawa, Takashi Sato, Masaharu Shinkai, Yoshimasa Takahashi, Xiuyuan Lu, Sho Yamasaki. Analysis of antigen specificity of Treg cell clonotypes expanded upon SARS-CoV-2 infection. International Immunology. 2024
Ayana Iijima, Kenshiro Matsuda, Sho Yamasaki, Kazuko Shibuya, Akira Shibuya. Clec12b Alleviates Mite-Induced Dermatitis by Regulating P2RX7-Mediated Mast Cell Activation in Mice. Allergy. 2024
Ryosuke Takasaki, Emi Ito, Masamichi Nagae, Yuki Takahashi, Takuro Matsuoka, Wakana Yasue, Norihito Arichi, Hiroaki Ohno, Sho Yamasaki, Shinsuke Inuki. Development of Ribityllumazine Analogue as Mucosal-Associated Invariant T Cell Ligands. Journal of the American Chemical Society. 2024
- 1993 Kyoto University Graduate School, Division of Agricultural Science
- 1991 Kyoto University Faculty of Agriculture
Professional career (1)：
ph.D.
Work history (8)：
2017/04 - 現在 Osaka University WPI Immunology Frontier Research Center
2017/02 - 現在 Osaka University Research Institute for Microbial Diseases
2014/04 - 現在 Chiba University Research Center for Pathogenic Fungi and Microbial Toxicoses
2009/04 - Kyushu University Medical Institute of Bioregulation
2004/04 - 理化学研究所 横浜研究所 上級研究員
1999/04 - 千葉大学医学研究院 遺伝子制御学 助手
1993/04 - 三菱化学総合研究所 研究員
1993 - Mitsubishi Chemical, 1999 Chiba University Graduate School of Medicine, 2004 RIKEN
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Committee career (5)：
- 現在 日本免疫学会 理事
- 現在 マクロファージ分子細胞生物学研究会 幹事
- 現在 日本免疫学会 評議員
- 現在 日本Cell Death学会 評議員
- 2020/08 日本インターフェロン・サイトカイン学会 推薦幹事
Awards (7)：
2022/11 - 公益財団法人 野口英世記念会 第65回野口英世記念医学賞
2021/03 - The Chemo-Sero-Therapeutic Research Institute The 2nd "Toyoichi Otawara Award"
2018 - Japanese Society for Immunology 21st JSI Award
2016 - Kurozumi Medical Foundation 52th The Saburo Kojima Memorial Award
2016 - The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (MEXT) Prizes for Science and Technology
2011 - The Japan Society for the Promotion of Science (JSPS) 7th JSPS PRIZE
2007 - Japanese Society for Immunology JSI Young Investigator Award
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Association Membership(s) (10)：
THE JAPANESE SOCIETY OF INFLAMMATION AND REGENERATION
, 日本インターフェロン・サイトカイン学会
, THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH
, THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS
, 日本Cell Death学会
, JAPANESE SOCIETY FOR BACTERIOLOGY
, THE JAPANESE BIOCHEMICAL SOCIETY
, 日本農芸化学会
, 日本癌学会
, 日本免疫学会
