Rchr
J-GLOBAL ID:200901006742252503
Update date: Nov. 06, 2024
Kurokawa Mineo
クロカワ ミネオ | Kurokawa Mineo
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://www.h.u-tokyo.ac.jp/hematology/
Research field (1):
Hematology and oncology
Research keywords (5):
hematopoietic stem cell transplantation
, hematological malignancy
, hematopoietic stem cell
, 白血病
, Leukemia
Research theme for competitive and other funds (43):
- 2022 - 2024 白血病の非ゲノム複製機構に着目した新規治療標的の探索
- 2021 - 2024 難治性白血病の制御機構解明に基づく革新的治療法の開発
- 2020 - 2022 Study for mechanisms of emergence of leukemia cell
- 2018 - 2021 Elucidation of pathogenesis and novel therapeutics for refractory leukemias
- 2016 - 2018 白血病幹細胞の維持におけるオートファジーの機能的役割の解明
- 2016 - 2017 detection of essential epigenetic marks for leukemogenesis
- 2015 - 2017 骨髄異形成症候群の造血抑制における、細胞競合の役割の解明
- 2010 - 2016 Control of cell fate decision in the cells differentiating to multiple pathways in a step-by-step fashion
- 2014 - 2015 Screening of factors regulating refractory leukemia using genome editting
- 2012 - 2015 Establishment of a platform for elucidation of molecular pathogenesis of leukemia and antileukemia therapy based on integrated pathway analysis
- 2013 - 2014 Elucidation of mechanisms of myelodysplastic syndrome progression by RNAi screening.
- 2011 - 2013 白血病幹細胞の維持機構の解明と治療標的の同定
- 2012 - 2012 Pathophysiological elucidation of refractory leukemias with the genetic analyses at the single-cell level
- 2007 - 2011 Elucidation of molecular pathogenesis and therapeutic targets for refractory hematological malignancies
- 2006 - 2007 AML1の機能不全による造血異常と白血病発症機構の解明
- 2005 - 2006 Comprehensive analysis of oncogenic transcriptional factor Evi-1.
- 2005 - 2005 造血幹細胞の可塑性の制御と再生医療への応用
- 2004 - 2005 Functional analysis of Blimp-1
- 2004 - 2004 造血系の構築および悪性化を制御するマスター遺伝子の同定
- 2003 - 2004 AML1による造血細胞の制御および悪性化機構の網羅的解析
- 2003 - 2003 ゲノムアレイCGHを用いた造血器腫瘍における染色体欠失・増幅領域の網羅的解析
- 2002 - 2003 幹細胞可塑性の分子メカニズムと再生医学研究
- 2002 - 2003 GENOM IC ANALYSIS OF (1;7) TRANSLOCATION AND del(7q) IN MYELODYSPLASTIC SYNDROME
- 2002 - 2003 Analysisof CIZ disrupted mice
- 2001 - 2003 白血病の分子機構解析とモデルマウスの作製
- 2001 - 2002 白血病原因遺伝子産物AML1の機能制御の分子機構
- 2001 - 2001 Evi-1による白血病発症における転写抑制因子の役割
- 2001 - 2001 造血細胞におけるNotchシグナル伝達に関わる分子の同定とその機能解析
- 2000 - 2001 Genomic analysis of recurrent unbalanced translocation t(1 ; 7)(q10 ; p10) in myelodysplastic syndrome
- 2000 - 2000 白血病原因遺伝子Evi-1による細胞増殖とアポトーシスの制御機構の解析
- 1999 - 2000 Analyses of Maltipotential Functions of a Novel Signaling Molecule, Cas
- 1999 - 2000 Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210^<bcr/abl>
- 1999 - 2000 Notch in hematopoiesis
- 1999 - 1999 モデルマウスを用いたPh1陽性白血病の病態の解析と治療への応用
- 1999 - 1999 ノックアウト細胞を用いた細胞骨格形成、細胞がん化におけるCasの役割
- 1994 - 1999 造血器腫瘍の遺伝子診断法の開発と実用化
- 1996 - 1997 造血器腫瘍の予後に関する遺伝子診断法の開発
- 1996 - 1997 Analysis of transcription factor abnormality in the progression of preleukemic state.
- 1996 - 1997 Functional regulation by phosphorylation of transcription factor AML1 which is involved in leukemogenesis
- 1996 - 1996 アデノウイルスを使ったEGF受容体遺伝子導入による造血幹細胞の増幅
- 1995 - 1996 Functional analysis of AML1 gene in normal hematopoietic cells and leukemia cells
- 白血病発症の分子機構
- Molecular mechanisms for leukemogenesis
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Papers (100):
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Masanori Toho, Megumi Yasunaga, Yasutaka Masuda, Arika Shimura, Yosuke Masamoto, Kensyo Sumi, Kyosuke Muramatsu, Masahiko Tsujita, Shuichiro Mitsuchi, Reo Yoshioka, et al. Adult T-cell leukemia-lymphoma with neurolymphomatosis successfully controlled by valemetostat: a case report and review of literature. Leukemia & lymphoma. 2024. 1-5
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Akira Honda, Yasutaka Masuda, Yu Oyama, Kensuke Matsuda, Hideaki Mizuno, Akiko M Saito, Yoshio Katayama, Norio Komatsu, Kazuhiro Toyama, Mineo Kurokawa. Prognostic factors of idiopathic hypereosinophilic syndrome: A nationwide survey in Japan. British journal of haematology. 2024
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Yosuke Masamoto, Akira Honda, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Mineo Kurokawa. Long-term remission after upfront autologous hematopoietic stem cell transplant for CD5+ diffuse large-B cell lymphoma. Journal of chemotherapy (Florence, Italy). 2024. 1-9
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Yosuke Masamoto, Mineo Kurokawa. A key to engineering natural killer cells to attack acute myeloid leukemia. Haematologica. 2024. 109. 4. 1032-1034
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Yasutaka Masuda, Sho Yamazaki, Akira Honda, Yosuke Masamoto, Mineo Kurokawa. Isolated massive pleural effusion as a manifestation of chronic graft versus host disease successfully treated with corticosteroid. Annals of hematology. 2024. 103. 4. 1403-1407
more...
MISC (20):
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大山 悠, 安永 愛, 本田 晃, 牧 宏彰, 正本 庸介, 小林 竜也, 若林 義賢, 奥川 周, 森屋 恭爾, 黒川 峰夫. 同種造血幹細胞移植後に生じたAchromobacter xylosoxidansによる蜂窩織炎. 臨床血液. 2021. 62. 6. 672-672
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戸田 郷太郎, 添田 光太郎, 荒川 直子, 升田 紫, 小林 直樹, 生島 芳子, 粟澤 元晴, 正本 庸介, 諏訪内 浩紹, 泉田 欣彦, et al. 食後のインスリン・LPSシグナルによるマクロファージのIL-10発現を介した糖新生抑制メカニズム. 糖尿病. 2021. 64. Suppl.1. YIA-2)
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Kensuke Takaoka, Masahito Kawazu, Junji Koya, Akihide Yoshimi, Yosuke Masamoto, MD PhD, Hiroaki Maki, Takashi Toya, Takashi Kobayashi, Yasuhito Nannya, et al. Human Germline HLTF E259K Mutation Identified in Familial MDS Patients Accumulates DNA Damage through Impaired PCNA Polyubiquitination. 2017. 130. 4238
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Ayato Tsukamoto, Yumiko Yoshiki, Sho Yamazaki, Keiki Kumano, Fumihiko Nakamura, Mineo Kurokawa. The significance of free light chain measurements in the diagnosis of myelomatous pleural effusion. Annals of Hematology. 2014. 93. 3. 507-508
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松川敬志, 山本知孝, 熊野恵城, 市川幹, 高橋祐二, 石浦浩之, 三井純, 田中真生, 後藤順, 黒川峰夫, et al. 思春期/成人大脳型副腎白質ジストロフィーに対する造血幹細胞移植の臨床的効果の検討. 日本神経学会学術大会プログラム・抄録集. 2013. 53. 12. 1519-1519
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Education (4):
- - 1995 The University of Tokyo
- - 1995 The University of Tokyo Graduate School, Division of Medical Sciences
- - 1990 The University of Tokyo Faculty of Medicine School of Medicine
- - 1990 The University of Tokyo Faculty of Medicine
Professional career (1):
- (BLANK) (The University of Tokyo)
Work history (11):
- 2008 - 現在 The University of Tokyo Faculty of Medicine University Hospital, Department of Cell and Gene Therapy
- 2005 - 現在 The University of Tokyo Heamatology and Oncology, Faculty of Medicine University Hospital
- 2019/04 - 2021/03 The University of Tokyo Graduate School of Medicine
- 2017/04 - 2019/03 The University of Tokyo Faculty of Medicine University Hospital
- 2017/04 - 2019/03 The University of Tokyo Faculty of Medicine University Hospital
- 2017/04 - 2019/03 The University of Tokyo Faculty of Medicine University Hospital
- 2017/04 - 2019/03 The University of Tokyo Faculty of Medicine University Hospital
- 2014/04 - 2019/03 The University of Tokyo Faculty of Medicine University Hospital
- 2013/04 - 2014/03 The University of Tokyo Faculty of Medicine University Hospital
- 2004 - 2005 東京大学医学部付属病院 血液・腫瘍内科 講師
- 1999 - 2003 東京大学医学部付属病院 血液・腫瘍内科 助手
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Committee career (9):
Awards (6):
- 2021/11 - 日本医師会優功賞
- 2011 - 日本癌学会Mauvernay賞
- 2000 - 東京都医師会研究賞
- 2000 - 日本医師会医学研究助成費
- 1999 - 日本癌学会奨励賞
- 1997 - 日本血液学会奨励賞
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Association Membership(s) (15):
日本臨床分子医学会
, American Society of Hematology
, 日本骨髄腫学会
, 日本炎症再生学会
, がん分子標的治療研究会
, American Society for Biochemistry and Molecular Biology
, 日本造血細胞移植学会
, 日本臨床腫瘍学会
, 日本免疫学会
, 米国血液学会
, 日本生化学会
, 日本分子生物学会
, 日本内科学会
, 日本癌学会
, 日本血液学会
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