Toshihiro Mitaka

2017 - 2019 In vitro reconstruction of hepatic tissue

2016 - 2019 The lineage plasticity fo mature hepatocytes during liver injury and regeneration

2016 - 2019 Tissue engineering for vascularization based on flow regulation

2014 - 2017 Translational research of the regenerative treatment of using human hepatic stem cells which were frozen by super-freezing program

2014 - 2017 Hepatic stem cells transplantation activates the growth of intrinsic hepatic progenitor cells in recipient rat livers.

2014 - 2016 Research for the establishment of human hepatocytic progenitor cells

2013 - 2016 Development of Tissue Engineering for Vascularization based on regulation of interstitial flow

2013 - 2016 Fundamental Researches for the Application of Human Small Hepatocytes in Clinical Treatment

2012 - 2014 Establishment of cell transplantation therapy for hepatic failure by hepatic stem/progenitor cells and/or hepatic organoids

2012 - 2013 Development of the liver lobule-type culture device

2011 - 2013 Roles of Lutheran in tumor cell adhesion and migration

2011 - 2013 A clinical and basic research for developing human small hepatocyte bank using super-cooling program and generating mass hybrid mouse.

2010 - 2012 Clinical and Basic Researches of Hepatic Stem Cells onLiver Regeneration as Defense Mechanism.

2009 - 2011 Basic research for the production of human hepatocytes and the transplantation of hepatic tissues

2008 - 2010 Development of hybrit mouse with humanized liver using superfreezing preserved human small hepatocytes.

2008 - 2010 Primary culture of hepatocytes on synthetic peptides mimicking the functions of laminin-111

2007 - 2009 Basic research objected to establish the highly qualified assessment of hepatic reserve function by utilizing new molecular marker localized in liver

2005 - 2007 Research for the formation of hepatic organoids by using human hepatic progenitor cells and the model of artificial liver device incorporated with human hepatic organoids

2005 - 2007 Role of laminin alpha5 and its receptors in fibrotic liver and hepatocellular carcinoma

2003 - 2005 Research of the mechanism of non-obstructive cholestasis in severe infection and of the treatment for hepatic insufficiency

2003 - 2004 再生毛細胆管の収縮を生み出す小型肝細胞収縮の同期機構のバイオメカニクス

2002 - 2004 Identification of specific surface proteins in small hepatocytes and reconstruction of hepatic organoids ex vivo.

2001 - 2004 Basic research of the treatment for hepatic failure by hepatocyte transplantation

2002 - 2003 Isolation and characterization of human hepatic stem/progenitor cells and reconstruction of liver tissue

2002 - 2002 肝・胆・膵系ステムセル・バイオロジーと臓器再生医療への展開

2000 - 2002 Study of analysis of bile stasis using the extracorporeal hepatic tissue model and of the effect of cell transplantation on hepatic failure

2000 - 2001 Basic research for the treatments of hepatic diseases by hepatic tissue transplantation

2000 - 2001 Development of bio-artificial liver by the mass transfer in the small hepatocytes

2000 - 2001 Research for the in vitro reconstruction of a hepatic tissue and for the treatment of hepatic failure by hepatic tissue transplantation

1998 - 2000 Research for the in vitro reconstruction of hepatic tissues: an application for an artificial liver.

1999 - 1999 肝・胆・膵系幹細胞の発生・分化・再生の分子機構

1997 - 1999 Changes of bile canalicular contraction and of specific receptors on hepatocyte membrane during cholestasis in peri-operation.

1996 - 1997 Research for the in vitro reconstruction of hepatic tissues : an application for an artificial liver.

1996 - 1996 新たにクローン化したCAKβおよびEfsの細胞接着、分化増殖、癌化における役割

1994 - 1994 肝細胞増殖に関与する各種増殖因子の作用機序の解析

1993 - 1993 肝細胞増殖に関与する各種増殖因子の作用機序の解析

1992 - 1992 ラット肝細胞の増殖及び分化の機序の解析

1991 - 1991 成熟ラット肝細胞のstem cellの同定とその分化

肝前駆細胞移植

人工肝臓研究

肝幹(前駆)細胞の増殖・分化機序の解明

In vitro肝組織形成