Rchr
J-GLOBAL ID：200901007303692129   Update date: Mar. 06, 2024

Tanimoto Keiji

タニモト ケイジ | Tanimoto Keiji
Affiliation and department：
Hiroshima University Research Institute for Radiation Biology and Medicine

About Hiroshima University Research Institute for Radiation Biology and Medicine


Research field  (2)： Surgical dentistry ,  Medical biochemistry
Research keywords  (6)： Pharmacogenetics ,  individualized therapy ,  hypoxia ,  Transcription ,  HIF-1 ,  transcription
Research theme for competitive and other funds  (14)：
  • 2021 - 2024 HIF-DEC下流のクリティカル遺伝子を標的としたがん治療分子標的治療法の開発
  • 2018 - 2021 Development of a molecular targeting anti-cancer therapy against hypoxia inducible DEC transcription factors
  • 2017 - 2019 Novel therapeutic and preventive strategy of resveratrol treatment in triple negative breast cancer cells
  • 2015 - 2017 Functions of a novel hypoxia-inducible reprogramming factor GLIS1 in cancer cells
  • 2015 - 口腔扁平上皮癌の悪性度を規定する転写因子DEC-Twist分子制御機構の解明
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Papers (105)：
  • Takako Sakamoto, Keiji Tanimoto, Hidetaka Eguchi, Shunta Sasaki, Kouki Tsuboi, Shin-ichi Hayashi, Sahoko Ichihara. Resveratrol exhibits diverse anti-cancer activities through epigenetic regulation of E-cadherin and p21 in triple-negative breast cancer cells. Breast Cancer. 2023
  • Nurina Febriyanti Ayuningtyas, Chanbora Chea, Toshinori Ando, Karina Erda Saninggar, Keiji Tanimoto, Toshihiro Inubushi, Nako Maishi, Kyoko Hida, Masanobu Shindoh, Mutsumi Miyauchi, Takashi Takata. Bovine lactoferrin inhibits tumor angiogenesis through NF-KB pathway inhibition by binding to TRAF6. Pharmaceutics. 2023. 15. 1. 165-165
  • Takahiro Fukazawa, Keiji Tanimoto, Emi Yamaoka, Masato Kojima, Masami Kanawa, Nobuyuki Hirohashi, Eiso Hiyama. Oncogenic Role of ADAM32 in Hepatoblastoma: A Potential Molecular Target for Therapy. Cancers. 2022. 14. 19
  • Maryami Yuliana Kosim, Takahiro Fukazawa, Mutsumi Miyauchi, Nobuyuki Hirohashi, Keiji Tanimoto. p53 status modifies cytotoxic activity of lactoferrin under hypoxic conditions. Frontiers in Pharmacology. 2022. 13. 988335-988335
  • Shimabukuro, Kiichi, Fukazawa, Takahiro, Kanai, Akinori, Kawai, Hidehiko, Mekata, Kengo, Hirohashi, Nobuyuki, Kakimoto, Naoya, Tanimoto, Keiji. Low-Dose-Rate Irradiation Suppresses the Expression of Cell Cycle-Related Genes, Resulting in Modification of Sensitivity to Anti-Cancer Drugs. CELLS. 2022. 11. 3
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MISC (28)：
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Lectures and oral presentations  (5)：
  • Significance of up-regulation of the hypoxia-inducible EFEMP2 in cancer cells
    (2021)
  • Resveratrol enhances hypoxia-induced p53 protein stabilization resulting in increase of apoptosis in breast cancer cells
    (2021)
  • Significance of low-dose-rate irradiation in anti-cancer therap
    (2021)
  • 低線量率放射線および低酸素刺激により変動する遺伝子群
    (第45回中国放射線影響研究会 2020)
  • The effects of low-dose irradiation on the hypoxic cells.
    (The 4th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science 2020)
Education (2)：
  • 1994 - 1998 Hiroshima University Graduate School, Division of Dental Research Graduate School, Division of Dental Research
  • 1988 - 1994 Hiroshima University Faculty of Dentistry
Work history (7)：
  • 2020/04 - 現在 Hiroshima University Research Institute for Radiation Biology and Medicine Associate Professor
  • 2017/02 - 2020/03 Hiroshima University Research Institute for Radiation Biology and Medicine
  • 2007/04 - 2017/03 Hiroshima University Research Institute for Radiation Biology and Medicine Assistant Professor
  • 2001/04/01 - 2007/03/31 Hiroshima University Research Institute for Radiation Biology and Medicine Research Associate
  • 2000/01/01 - 2001/03/31 Japan Society for the Promotion of Science research fellow
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Association Membership(s) (10)：
The Japanese Pharmacological Society ,  日本癌治療学会 ,  日本癌学会 ,  日本歯科基礎医学会 ,  日本口腔外科学会 ,  日本分子生物学会 ,  放射線影響学会 ,  がん分子標的治療学会 ,  がんとハイポキシア研究会 ,  American Association for Cancer Research
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