Rchr
J-GLOBAL ID:200901007562513135   Update date: Aug. 16, 2024

Kobayashi Toshiyuki

コバヤシ トシユキ | Kobayashi Toshiyuki
Affiliation and department:
Research field  (3): Experimental pathology ,  Molecular biology ,  Laboratory animal science
Research keywords  (4): Tuberous Sclerosis ,  腫瘍抑制遺伝子 ,  動物モデル ,  Genetics
Research theme for competitive and other funds  (28):
  • 2022 - 2025 極長鎖脂肪酸をターゲットとした新規抗癌治療戦略
  • 2021 - 2024 Mechanism elucidation for influences of the Parkinson disease after appendectomy
  • 2019 - 2022 Anticancer treatment targeted fot VLCFA
  • 2016 - 2020 Devolopment for highly sensitive and quantitative methods with a facile, fast and low-cost protocol.
  • 2017 - 2020 結節性硬化症遺伝子変異が惹起する代謝変動とエピゲノム制御異常の解明
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Papers (101):
  • Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Ikeda. Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex. 2022
  • Hiroko Sugiura, Tadayuki Shimada, Keiko Moriya-Ito, Jun-Ichi Goto, Hiroki Fujiwara, Rie Ishii, Hiroshi Shitara, Choji Taya, Satoshi Fujii, Toshiyuki Kobayashi, et al. A Farnesyltransferase Inhibitor Restores Cognitive Deficits in Tsc2+/- Mice through Inhibition of Rheb1. The Journal of Neuroscience. 2022. 42. 12. 2598-2612
  • 折田 創, 李 賢哲, 小林 敏之, 中岡 博史, 吉本 雄太郎, 山内 卓, 加治 早苗, 岡 伸一, 綿田 裕孝, 福永 哲. 糖尿病症例における内臓脂肪と皮下脂肪の組成の違いについて. 日本消化器外科学会総会. 2021. 76回. P270-7
  • Tatsuhiro Sato, Satomi Mukai, Haruna Ikeda, Emi Mishiro-Sato, Ken Akao, Toshiyuki Kobayashi, Okio Hino, Wataru Shimono, Yoshio Shibagaki, Seisuke Hattori, et al. Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation. Molecular Cancer Research. 2021. 19. 5. 921-931
  • 張 順, 伊志嶺 百々子, 小平 佳典, 折田 創, 小林 敏之, 樋野 興夫, 横溝 岳彦, 福永 哲, 李 賢哲. カルボキシルエステラーゼ2の消化器癌における発現調節機構の解明(The regulatory mechanisms of carboxylesterases 2 in gastrointestinal cancers). 日本薬学会年会要旨集. 2020. 140年会. 26L-am01
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MISC (135):
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Books (11):
  • 結節性硬化症の診断と治療最前線
    診断と治療社 2016
  • 細胞工学
    学研メディカル秀潤社 2013
  • Seriesモデル動物利用マニュアル:疾患モデルの作製と利用-がん
    エル・アイ・シー 2012
  • Annual Review 腎臓 2012
    中外医薬社 2012
  • Cancer: Cell Structure, Carcinogenesis and Genomic Instability
    Birkhäuser Verlag 2006
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Lectures and oral presentations  (1):
  • Exploring downstream pathways of Erc/Msln as therapeutic targets of TSC
    (International Tuberous Sclerosis Complex Research Conference 2018 2018)
Education (4):
  • - 1992 Nagoya University
  • - 1992 Nagoya University Graduate School, Division of Natural Science
  • - 1987 Niigata University Faculty of Science
  • - 1987 Niigata University Faculty of Science
Professional career (1):
  • Doctor(Science) (Nagoya University)
Work history (6):
  • 1996 - 2004 (財)癌研究会癌研究所実験病理部 研究員
  • 1996 - 2004 Associate, Dept. of Exp. Pathol., Cancer
  • 1993 - 1996 (財)癌研究会癌研究所実験病理部 嘱託研究員
  • 1993 - 1996 Attending Associate, Dept. of Exp. Pathol.,
  • Institute, Japanese
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Awards (1):
  • 1999 - 癌学会奨励賞
Association Membership(s) (8):
The Japanese Society Of Child Neurology ,  The Japanese Society of Tuberous Sclerosis Complex ,  THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER ,  The Japanese Society for Familial Tumors ,  日本癌学会 ,  日本分子生物学会 ,  The Molecular Biology Society of Japan ,  The Japanese Cancer Association
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