Rchr
J-GLOBAL ID：200901007605888928
Update date: Jun. 25, 2024
Takashi Kojima
コジマ タカシ | Takashi Kojima
Affiliation and department：
Job title：
Professor
Research field (1)：
Cell biology
Research keywords (3)：
Cell Science
, 細胞生物学
, 実験病理学
Research theme for competitive and other funds (29)：
- 2021 - 2024 唾液腺免疫性疾患における腺機能障害に対する基礎的研究
- 2019 - 2022 Analyses of malignant mechanisms via abnormality of novel multifunctional tricellular junction molecules in cancer cells
- 2018 - 2022 膵管内乳頭粘液性腫瘍の新規マウスモデルで発見された病態分子の臨床応用的機能解明
- 2018 - 2021 The mechanisms of salivary gland fibrosis in IgG4-related disease
- 2017 - 2019 Characterization of distal airway stem-like cells expressing N-terminally truncated p63 and thyroid transcription factor-1 in the human lung
- 2016 - 2019 The role of ASPP2/LSR/AMOT/Merlin/YAP-protein complex at tricellular contacts of normal and cancer cells
- 2015 - 2018 A novel tricellular tight junction molecule LSR in diagnosis and therapy for cancer
- 2014 - 2017 Research of the inhibitory factors by regulation of epithelial cell polarity and organogenesis signaling in pharyngeal cancer invasion/metastasis
- 2012 - 2015 Patho-physiology of the tight junction-mainly focusing on human normal epithelial cells.
- 2012 - 2014 Therapeutic approach using analysis of type III IFN SNPs in upper respiratory disease
- 2011 - 2014 Interaction between mucosal epithelium and immune system in human nasal mucosa.
- 2011 - 2013 The basic study of molecular targeted therapy via pancreatic duct tight junctions by using a novel culture system of human pancreatic duct epithelial cells
- 2010 - 2012 Clinical and Basic Researches of Hepatic Stem Cells onLiver Regeneration as Defense Mechanism.
- 2008 - 2010 Regulation of human nasal mucosal barrier by tight junctions via innate immunity
- 2008 - 2009 The role of dendritic cell-activating factor TSLP in allergic rhinitis
- 2007 - 2009 Analysis of relationship in immune barrier function between human nasal epithelial cell and dendritic cell.
- 2007 - 2009 Basic research objected to establish the highly qualified assessment of hepatic reserve function by utilizing new molecular marker localized in liver
- 2007 - 2009 Pathobiology of the tight junction : from cell biology of paracellular pathway to bed-side
- 2005 - 2007 Biological barrier and human diseases
- 2005 - 2006 Regulation of bile canalicular barrier by a novel tight junction protein claudin-2 during cholestasis
- 2002 - 2004 Molecular pathophysiology of the biological barrier regulation of molecular passage through paracellular spaces.
- 2001 - 2002 The role of gap and tight junctions during liver regeneration
- 2001 - 2001 ギャップ結合による肝がん発生の抑制メカニズム
- 2000 - 2001 Research for the in vitro reconstruction of a hepatic tissue and for the treatment of hepatic failure by hepatic tissue transplantation
- 2000 - 2000 ギャップ結合による肝がん発生の抑制メカニズム
- 1999 - 2000 Cell biological study of glutamate receptor and gap jujunction in delyed neuronal death
- 1996 - 1997 肝細胞の増殖および分化におけるgap junctionの発現調節機構の解明
- 耳鼻科領域におけるギャップおよびタイト結合と疾患
- 肝細胞におけるギャップおよびタイト結合蛋白の発現調節機構の解析
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Papers (105)：
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Arisa Kura, Kimihito Saito, Takumi Konno, Takayuki Kohno, Hiroshi Shimada, Tadahi Okada, Soshi Nishida, Daichi Ishii, Motoki Matsuura, Tsuyoshi Saito, et al. The roles of tight junction protein cingulin in human endometrioid endometrial cancer. Tissue barriers. 2024. 2361976-2361976
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Daichi Ishii, Yuma Shindo, Wataru Arai, Takumi Konno, Takayuki Kohno, Kazuya Honda, Masahiro Miyajima, Atsushi Watanabe, Takashi Kojima. The Roles and Regulatory Mechanisms of Tight Junction Protein Cingulin and Transcription Factor Forkhead Box Protein O1 in Human Lung Adenocarcinoma A549 Cells and Normal Lung Epithelial Cells. International journal of molecular sciences. 2024. 25. 3
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Takumi Konno, Takayuki Kohno, Shin Kikuchi, Arisa Kura, Kimihito Saito, Tadahi Okada, Hiroshi Shimada, Yuya Yamazaki, Tomoki Sugiyama, Motoki Matsuura, et al. The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line. Tissue barriers. 2024. 2304443-2304443
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Wataru Arai, Takumi Konno, Takayuki Kohno, Yuki Kodera, Mitsuhiro Tsujiwaki, Yuma Shindo, Hirofumi Chiba, Masahiro Miyajima, Yuji Sakuma, Atsushi Watanabe, et al. Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells. Oncotarget. 2023. 14. 261-275
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Takayuki Kohno, Takashi Kojima. Atypical Macropinocytosis Contributes to Malignant Progression: A Review of Recent Evidence in Endometrioid Endometrial Cancer Cells. Cancers. 2022. 14. 20
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MISC (168)：
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石井 大智, 進藤 悠真, 新井 航, 金野 匠, 幸野 貴之, 宮島 正博, 小島 隆, 渡辺 敦. 肺腺癌におけるタイト結合分子cingulinおよび転写因子FOXO1の役割. 肺癌. 2022. 62. 6. 635-635
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進藤 悠真, 新井 航, 金野 匠, 幸野 貴之, 宮島 正博, 小島 隆, 渡辺 敦. 正常ヒト肺上皮細胞におけるTGF-βとHDAC阻害剤のタイト結合分子および上皮バリアへの影響. 日本呼吸器外科学会雑誌. 2021. 35. 3. RO18-3
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嶋田 浩志, 岡田 匡氷, 金野 匠, 幸野 貴之, 松浦 基樹, 郷久 晴朗, 岩崎 雅宏, 小島 隆, 齋藤 豪. タイト結合分子Cluadin-2をターゲットにした子宮内膜癌治療のin vitroにおける検討. 日本婦人科腫瘍学会雑誌. 2021. 39. 1. 285-285
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郷久 晴朗, 嶋田 浩志, 岩崎 雅宏, 染谷 真行, 金野 匠, 菊池 真, 幸野 貴之, 玉手 雅人, 松浦 基樹, 小島 隆, et al. タイト結合による子宮内膜の悪性化制御機序. 北日本産科婦人科学会総会・学術講演会プログラム・抄録集. 2019. 67回. 36-36
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郷久 晴朗, 嶋田 浩志, 岩崎 雅宏, 秋元 太志, 西村 庸子, 玉手 雅人, 寺田 倫子, 松浦 基樹, 金野 匠, 幸野 貴之, et al. 子宮内膜悪性化におけるタイト結合分子claudin-2の関与. 日本婦人科腫瘍学会雑誌. 2019. 37. 3. 497-497
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Education (2)：
- 1983 - 1985 Gifu University
- 1979 - 1983 Gifu University
Professional career (1)：
- Doctor of Medical Science
Awards (3)：
- 2005 - 秋山財団 一般助成
- 2005 - 日本臨床分子形態学会論文賞
- 2004 - 日本臨床電子顕微鏡学会奨励賞
Association Membership(s) (5)：
日本分子生物学会
, 日本臨床分子形態学会
, 米国細胞生物学会
, 日本細胞生物学会
, 日本癌学会
