Rchr

J-GLOBAL ID：200901007643789429 Update date: Mar. 05, 2024

Ohdan Hideki

オオダンヒデキ | Ohdan Hideki

Affiliation and department：
Job title： Professor
Other affiliations (2)：

Hiroshima University Vice President (Research and Development)
Science Council of Japan

Homepage URL (1)： https://home2ge.hiroshima-u.ac.jp/

Research field (3)： General surgery, pediatric surgery , Immunology , Digestive surgery

Research keywords (23)： Surgery , Liver transplantation , Natural Killer Therapy , Liver , Hepato-Biliary-Pancreatic Surgery , COVID-19 , Pancreas transplantation , Kidney transplantation , Small intestine transplantation , Immune tolerance , T cell , iPS cell , TAP , genome , B cell , Transplantation , Immunology , NK cell , human leukocyte antigen , TRAIL , ISM ODN , Macrophage , ABO incompatible

Research theme for competitive and other funds (34)：

2023 - 2028 切除不能な肝門部領域胆管癌に対する生体肝移植で治癒に至る分子生物学的特性の解明
2022 - 2025 Elucidation of the mechanism of cancer immune evasion by glycan-responsive B cells and development of regulatory methods
2020 - 2025 Multidimensional Analysis of operationally tolerance in living donor liver transplant patients
2021 - 2024 免疫抑制薬がSARS-CoV-2ゲノム複製とT細胞応答へ及ぼす影響の解明
2019 - 2022 Development of therapeutic methods for controlling novel cancer immune-evasion mechanisms by non-conventional B cells

2018 - 2021 Elucidation of novel rejection mechanism after HLA-matched transplantation using allogeneic iPS cells

2018 - 2021 Establishment of a therapeutic method to induce Treg through steroid receptor in organ transplantation.

2017 - 2020 Basic research for gastric organoids using microgravity environment

2018 - 2019 生体肝移植術後患者に対する受動立位と移植肝血行動態の関係の解明

2015 - 2018 Analysis of association between allo-immune response and FOXP3 polymorphism in organ transplantation

2015 - 2018 Development of a novel desensitization/immune-regulatory method by use of multi-potent suppressor B cells to induce immune-tolerance in allogeneic organ transplantation

2016 - 2018 多機能幹細胞を用いた自然免疫再構築による新規肝炎/肝癌治療法の開発

2015 - 2017 Establishment of a method for immunostimulation to compensate gene polymorphism-associated deterioration of NK cell function

2014 - 2017 Development of prevention method using liver sinusoidal endothelial cells for food allergy

2013 - 2017 Establishment of a novel mouse colon cancer disease model with different genome instability useful for subclass classification

2013 - 2016 A study for immunological feature of tumor endothelial cells (TEC) in immune evasion mechanism of tumor micro-environment and development of a novel anti-cancer therapy

2013 - 2015 Development of novel cell therapeutic strategy using unlicenced NK cells combined with molecular target medicine for liver cancer

2012 - 2015 Generation of TRAIL positive NK cells from hematopoietic stem cells / iPS cells in vitro for anti-HCC immunotherapy

2013 - 2015 多機能幹細胞を用いた自然免疫再構築による肝炎治療法の開発と臨床応用

2011 - 2014 The CD47-SIRPa signaling blockade accelerates macrophage phagocytic activity against cancer cells

2011 - 2012 Establishment of strategies to regulate antibody-mediated rejection on the basis of B cell differentiation biology

2010 - 2012 The new strategy of NK cell therapy with death receptors for the patients with chollangiocellular carcinoma or mixed liver cancer

2009 - 2010 肝移植後免疫クロストークから発想した増殖性NKT細胞による新規抗HCV療法の開発

2008 - 2010 Inhibition of xeno-antigen reactive T cells and B cells by regulation of CD47-SIRP signaling

2007 - 2010 GalT-knockout pig to monkey xenogeneic kidney and islet transplantation

2007 - 2008 活性化NK細胞移入療法によるC型ウイルス性肝炎の移植後再発防止法の開発

2006 - 2007 Elucidation of the mechanism on carbohydrate antigen recognition by B cells through CD1d mediated signaling and establishment of a method to regulate B cells responding to the carbohydrate antigens in ABO-incompatible transplantation and xe

2006 - 2007 Regulation of innate and adaptive immune responses in xenotransplantation by modulating CD47sirp α signaling

2006 - 2007 新たに同定した肝類洞内皮細胞のT細胞抑制機構を応用した移植免疫制御法の開発

2005 - 2006 近赤外生体分光測定による非侵襲的肝内トリグリセライド定量法の確立

2005 - 2006 骨髄由来再生内皮細胞を用いた臓器移植免疫寛容の誘導

2005 - 2006 ステロイド離脱療法を目指した無毒化エンドトキシンアナログによる免疫制御療法の確立

2004 - 2005 Development of synthetic immunotoxin that can enable ABC incompatible transplantation and xenotransplantation.

2004 - 2005 Elucidation of mechanisms for macrophage-mediated xenograft refection and a novel approach to prevent macrophage-mediated xenograft rejection by gene introduction of human CD47 to xenogenic cells

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Papers (878)：

Kouki Imaoka, Masahiro Ohira, Tomoaki Bekki, Koki Sato, Yuki Imaoka, Ryosuke Nakano, Takuya Yano, Hiroshi Sakai, Naoki Tanimine, Seiichi Shimizu, et al. Arteriosclerosis Decreases Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Expression on Liver Natural Killer Cells in Living Donor Liver Transplantation. Transplantation proceedings. 2023. 55. 4. 906-912
Ryuta Ide, Masahiro Ohira, Yuki Imaoka, Kouki Sato, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan. Impact of Abdominal Aortic Calcification on Chronic Kidney Disease After Liver Transplantation: A Retrospective Study. Transplantation proceedings. 2023. 55. 4. 956-960
Yuki Imaoka, Masahiro Ohira, Kouki Imaoka, Tomoaki Bekki, Ryosuke Nakano, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, et al. Surgery-related disseminated intravascular coagulation predicts postoperative complications. BMC surgery. 2023. 23. 1. 86-86
Kentaro Ide, Hiroshi Sakai, Ryosuke Nakano, Yuki Imaoka, Naoki Tanimine, Ryuta Ide, Naofumi Tsukiyama, Kosuke Ono, Tetsuya Mochizuki, Ryosuke Arata, et al. Effectiveness of Thermal Barrier Bag for Prolonged Vascular Anastomosis in Kidney Transplantation. Transplantation proceedings. 2023. 55. 4. 752-755
Takao Hisashi, Fudeyasu Kenichi, Tahara Hiroyuki, Ohira Masahiro, Shimizu Seiichi, Ohdan Hideki, Mikami Yukio. Evaluation of Liver Hemodynamics at Early Mobilization in a Patient after Living Liver Transplantation -A case report-. Journal of Physical Therapy Practice and Research. 2023. 33. 1. 42-46

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MISC (884)：

小坂正成, 河岡友和, 上平祐輔, 白根佑樹, 三浦崚一, 村上せらみ, 矢野成樹, 網岡慶, 鳴戸謙輔, 安藤雄和, et al. A patient with chronic hepatitis B who developed hepatocellular carcinoma with hypervascularity in 9 years of close follow-up. 肝臓. 2022. 63. 1
末廣洋介, 河岡友和, 相方浩, 内川慎介, 児玉健一郎, 難波麻衣子, 大屋一輝, 盛生慶, 中原隆志, 村上英介, et al. アルコール性肝障害を背景とした、肝細胞癌と細胆管細胞癌の重複肝癌の一例. 肝臓. 2021. 62. 5. 300-309
大段秀樹, 尾上隆司. 【肝類洞壁細胞研究における新知見】肝移植の免疫寛容と肝類洞内皮細胞. 肝胆膵. 2021. 82. 4. 601-609
赤羽慎太郎, 小林剛, 仙谷和弘, 藤木佑斗, 谷山大樹, 大上直秀, 田邊和照, 大段秀樹, 安井弥. 胃癌におけるClaspin発現と予後・生物学的役割について(Prognostic value of claspin and its biological role in gastric cancer). 日本胃癌学会総会記事. 2021. 93回. 259-259
原田健司, 坂本直也, 鵜飼翔一, ファム・クオックタング, 高島剛志, 丸山諒太, 本間りりの, 谷山大樹, 田邊和照, 大段秀樹, et al. オキサリプラチン耐性胃癌オルガノイドの樹立及びその機能的解析(Establishment and functional analysis of oxaliplatin resistant gastric cancer organoids). 日本胃癌学会総会記事. 2021. 93回. 267-267

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Patents (23)：

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Books (1)：

異種細胞および臓器移植におけるマクロファージ性拒絶機構の解明とその制御法の確立
広島大学病院 2006

Lectures and oral presentations (1)：

Molecular mechanisms of accommodation in ABO- and HLA-incompatible organ transplantation
(TTS Masterclass 2021 2021)

Education (2)：

1993 - 1997 Hiroshima University Graduate School of Medical Sciences
1982 - 1988 Hiroshima University School of medicine

Professional career (2)：

MD (Hiroshima University)
Ph.D. (Hiroshima University)

Work history (11)：

2019/04 - 現在 Hiroshima University Professor
2017/04 - 2019/03 Hiroshima University Professor
2012/04 - 2017/03 Hiroshima University Professor
2008/04 - 2012/03 Hiroshima University Professor
2007/04 - 2008/03 Hiroshima University Associate Professor

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Committee career (7)：

2022/07 - 現在 The Japanese Society of Gastroenterological Surgery Councilor
2022/06 - 現在 Japanese Society of Hepato-Biliary-Pancreatic Surgery Councilor
2017/06 - 現在 Japanese Liver Transplantation Society President
2012/03 - 現在 Japan Surgical Society Representative
2011/11 - 2023/11 The Japan Society for Transplantation Director

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Awards (6)：

2015/11 - Hiroshima University Distinguished Professor
2009/12 - Hiroshima Prefecture Certificate of gratitude from Hiroshima Prefecture Governor
2005/06 - 日本肝移植研究会平成17年(第23回)日本肝移植研究会優秀演題賞肝移植後免疫応答における肝類洞内皮細胞の役割
2004/06 - Alumni association Koujin of Department of Medicine at Hiroshima University The 7th Basic Medical Research Award
1996/06 - 広仁会 (第14回)平成7年度広島大学医学部広仁会賞肝臓移植における近赤外分光法を用いた一酸化窒素産生と組織酸素化の同時評価

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Association Membership(s) (13)：

日本再生医療学会 , 中国四国臨床臓器移植研究会 , THE TRANSPLANTATION SOCIETY , AMERICAN SOCIETY OF TRANSPLANTATION , JAPAN SURGICAL ASSOCIATION , JAPAN SOCEITY FOR PANCREAS AND ISLET TRANSPLANTATION , JAPANESE SOCEITY FOR CLINICAL RENAL TRANSPLANTATION , JAPANESE LIVER TRANSPLANTATION SOCIETY , JAPANESE SOCIETY OF HEPATO-BILIARY-PANCREATIC SURGERY , THE JAPANESE SOCIETY OF GASTROENTEROLOGICAL SURGERY , THE JAPAN SOCIETY FOR TRANSPLANTATION , JAPAN SURGICAL SOCIETY , 日本臓器保存生物医学会

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