Rchr
J-GLOBAL ID：200901008093652087   Update date: Mar. 21, 2025

Fukai Shuya

フカイ シユウヤ | Fukai Shuya
Affiliation and department：
Kyoto University Department of Chemistry, Graduate School of Science

About Kyoto University Department of Chemistry, Graduate School of Science


Job title： Professor
Homepage URL  (2)： http://kuchem.kyoto-u.ac.jp/kozo/index.html ,  http://kuchem.kyoto-u.ac.jp/kozo/index_en.html
Research field  (1)： Structural biochemistry
Research keywords  (2)： 構造生物化学 ,  Structural biological chemistry
Research theme for competitive and other funds  (18)：
  • 2018 - 2023 Ubiquitin structural biology providing the molecular basis for chemo-technologies
  • 2018 - 2023 New frontier for ubiquitin biology driven by chemo-technologies
  • 2018 - 2022 Structural analysis of the epilepsy-related protein complex LGI1-ADAM22-PSD-95 and its regulatory factors
  • 2015 - 2018 BRCC36複合体によるK63結合型ユビキチン鎖特異的切断メカニズムの解明
  • 2012 - 2016 Structural basis for ubiquitin chain-mediated DNA damage responses
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Papers (88)：
  • Takayuki Yamaguchi, Kei Okatsu, Masato Kubota, Ayuka Mitsumori, Atsushi Yamagata, Yuko Fukata, Masaki Fukata, Mikihiro Shibata, Shuya Fukai. Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22. bioRxiv. 2025
  • Takafumi Furuhata, Bumkyu Choi, Taiki Uno, Ryota Shinohara, Yusuke Sato, Kei Okatsu, Shuya Fukai, Akimitsu Okamoto. Chemical Diversification of Enzymatically Assembled Polyubiquitin Chains to Decipher the Ubiquitin Codes Programmed on the Branch Structure. Journal of the American Chemical Society. 2024
  • Ryota Takeda, Erika Tsutsumi, Kei Okatsu, Shuya Fukai, Kazuki Takeda. Structural characterization of green fluorescent protein in the I-state. Scientific reports. 2024. 14. 1. 22832-22832
  • Erika Tsutsumi, Satomi Niwa, Ryota Takeda, Natsuki Sakamoto, Kei Okatsu, Shuya Fukai, Hideo Ago, Satoshi Nagao, Hiroshi Sekiguchi, Kazuki Takeda. Structure of a putative immature form of a Rieske-type iron-sulfur protein in complex with zinc chloride. Communications Chemistry. 2023. 6. 1. 190-190
  • Shoun Taguchi, Satomi Niwa, Hoang-Anh Dao, Yoshihiro Tanaka, Ryota Takeda, Shuya Fukai, Kazuya Hasegawa, Kazuki Takeda. Detailed analysis of distorted retinal and its interaction with surrounding residues in the K intermediate of bacteriorhodopsin. Communications Biology. 2023. 6. 1
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MISC (24)：
  • 古畑隆史, CHOI Bumkyu, 宇野大輝, 佐藤裕介, 佐藤裕介, 尾勝圭, 深井周也, 岡本晃充. Chemical diversification of C-terminal of proximal ubiquitin in the synthetic heterotypic polyubiquitin chain. 日本化学会春季年会講演予稿集(Web). 2024. 104th
  • 尾勝圭, 山野晃史, 松田憲之, 深井周也. RAB7Aシャペロンの基質特異性. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th
  • 尾勝圭, 山野晃史, 松田憲之, 深井周也. Structural basis for the recognition of RAB7A by RAB7A-chaperone. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
  • 山本隼士, 尾勝圭, 深井周也. Structural basis of the interaction between autophagy-related proteins SINTBAD and TBK1. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
  • 山口貴之, 三森愛結佳, 久保田将斗, 尾勝圭, 山形敦史, 深田優子, 深田優子, 深田正紀, 深田正紀, 深井周也. Cryo-EM analysis of epilepsy-related ligand-receptor complex LGI1-ADAM22. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
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Lectures and oral presentations  (35)：
  • Identification of Peptidic Inhibitors Targeting p97-hUfd1-hNpl4 Complex
    (日本薬学会年会要旨集(Web) 2022)
  • 炎症シグナルタンパク質TAB2のNZFドメインによるK6結合型ユビキチン鎖認識の構造基盤
    (日本蛋白質科学会年会プログラム・要旨集 2022)
  • ケモテクノロジーが拓くユビキチンニューフロンティア ヒトDUBアレイ技術を用いたUSP特異的阻害剤の開発
    (日本生化学会大会プログラム・講演要旨集 2020)
  • ユビキチンリガーゼUBE3Aは26Sプロテアソームの負の調節因子である
    (日本分子生物学会年会プログラム・要旨集(Web) 2020)
  • PINK1 activation by its unconventional localization to the outer mitochondrial membrane
    (日本分子生物学会年会プログラム・要旨集(Web) 2019)
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Education (2)：
  • - 2002 The University of Tokyo
  • - 1997 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
Professional career (1)：
  • Doctor of Science (The University of Tokyo)
Work history (7)：
  • 2020/03 - 現在 Kyoto University Department of Chemistry, Graduate School of Science Professor
  • 2018/04 - 2020/02 The University of Tokyo Institute for Quantitative Biosciences Associate Professor
  • 2016/12 - 2018/03 The University of Tokyo Institute of Molecular and Cellular Biosciences Associate Professor
  • 2007/05 - 2016/11 The University of Tokyo Organization for Synchrotron Radiation Research Associate Professor
  • 2006/04 - 2007/05 Tokyo Institute of Technology Center for Biological Resources and Informatics Associate Professor
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