HIDEAKI TSUGE

ツゲヒデアキ | HIDEAKI TSUGE

Affiliation and department：
Homepage URL (1)： http://www.cc.kyoto-su.ac.jp/~tsuge/tsugelab/index.html

Research field (4)： Medical biochemistry , Bacteriology , Structural biochemistry , Biophysics

Research keywords (8)：細菌、毒素、ウィルスの細胞侵入機構 , カテプシン阻害剤 , ディフィシル菌二成分毒素CDT , ウェルシュ菌イオタ毒素 , クライオ電子顕微鏡単粒子解析 , X線結晶構造解析 , タンパク質膜透過機構 , ADPリボシル化

Research theme for competitive and other funds (23)：

2024 - 2027 Role of encapsulin and DyP from cellulose high-producing bacateria
2024 - 2027 Toxin membrane translocation system approached by liposome single particle analysis
2021 - 2024 Dynamic Structural Analysis of Protein Translocation Across Membrane by Cryo-EM
2018 - 2021 Structural and Functional Study of Binary Toxin Translocon by Cryo-EM and X-ray Crystallography
2015 - 2018 Rho GTPase Recognition Mechanism of ADP-ribosylating C3 exoenzyme

2014 - 2017 Rational design of DyP type peroxidase based on the topology

2014 - 2016 Structure-activity relationship of carcinogenic factor, Tip-alpha, from Helicobacter pylori

2013 - 2015 複合体構造解析による細菌毒素の標的結合タンパク質認識機構の解明

2012 - 2014 Colloidal crystallization of protein molecules

2011 - 2013 複合体構造解析によるADPリボシル化毒素の標的タンパク質認識機構の解明

2010 - 2012 Characterization of the catalytic mechanism of DyP which is a representative novel peroxidase family.

2009 - 2011 Structural and functional basis of the complex of mono-ADP-ribosylating toxin and substrate protein

2008 - ビタミンB関連酵素の構造と機能研究

2007 - 2008 Structural and cell biological study of sphingolipid metabolic enzyme

2005 - 2006 Structural basis of the neutral sphingomyelinase to understand the lipid raft

2004 - 2006 Structural analysis of endonuclease-DNA interaction and alteration of substrate specificity

2004 - 2005 Molecular biological and structural analysis of toxic and enzymatic activities in Clostridium perfringens alpha-toxin

2003 - 2005 Dynamic structure of intermedilysin : Analysis of membrane binding region

2000 - 2000 リソゾーム由来の新カスパーゼ3活性化酵素と肝癌におけるこの欠如

1999 - 1999 蛋白立体構造に基づく6種カテプシン分別阻害剤開発とそれによる新生理機能の解明

1998 - 1998 ビタミンB_6による抗原プロセッシンダ酵素カテプシンBの阻害と免疫応答抑制

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Papers (105)：

Akihiro Kawamoto, Tomohito Yamada, Toru Yoshida, Yusui Sato, Takayuki Kato, Hideaki Tsuge. Cryo-EM structures of the translocational binary toxin complex CDTa-bound CDTb-pore from Clostridioides difficile. Nature Communications. 2022. 13. 1. 6119-6119
Toru Yoshida, Hideaki Tsuge. Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases. Toxins. 2021. 13. 1. 40-40
Tomohito Yamada, Hideaki Tsuge. Preparation of Clostridium perfringens binary iota-toxin pore complex for structural analysis using cryo-EM. Methods in enzymology. 2021. 649. 125-148
Hideaki Tsuge. A myelin sheath protein forming its lattice. Journal of Biological Chemistry. 2020. 295. 26. 8706-8707
Tomohito Yamada, Toru Yoshida, Akihiro Kawamoto, Kaoru Mitsuoka, Kenji Iwasaki, Hideaki Tsuge. Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex. Nature Structural & Molecular Biology. 2020. 27. 3. 288-296

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MISC (11)：

吉田徹, 津下英明. ADPリボシル化酵素がタンパク質やDNAを特異的に修飾する仕組み. 生化学. 2021. 93. 6. 862-866
M. Nagahama, M. Oda, H. Tsuge, K. Kobayashi. Enteric toxins of Clostridium perfringens: Beta-toxin, tpeL, epsilon-toxin and iota-toxin. Molecular Medical Microbiology (Second edition). 2015. 2. 997-1013
Modification reaction mechanism based on the complex structure of enzyme-substrate protein at pre- and post-reaction states : The reaction mechanism of iota toxin from Clostridium perfringens. 2014. 27. 5. 233-240
Hideaki Tsuge, Toshiharu Tsurumura, Hiroko Utsunomiya, Daisuke Kise, Takashi Kuzuhara, Tatsuro Watanabe, Hirota Fujiki, Masami Suganuma. Structural basis for the helicobacter pylori-carcinogenic TNF(-inducing protein. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2011. 67. C475-C475
渡邉達郎, 津下英明, 藤井温子, 高橋淳, 藤木博太, 菅沼雅美. Helicobacter pyloriの遺伝子を用いた研究:病原因子から分子疫学まで Helicobacter pyloriのTipαによるヌクレオリンを介した発がん促進機構. Helicobacter Research. 2010. 14. 4

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Lectures and oral presentations (57)：

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Education (2)：

Professional career (1)：

Work history (8)：

2018/04 - 現在 Kyoto Sangyo University
2016/04 - 現在 Kyoto Sangyo University Institute for Protein Dynamics
2010/04 - 現在 Kyoto Sangyo University Faculty of Life Sciences, Department of Bioresource and Environmental Sciences
2002/04 - 2010/03 徳島文理大学健康科学研究所兼人間生活学部(旧家政学部) 教授
2003/04 - 2009/03 The University of Tokushima

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Committee career (9)：

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Awards (1)：

Association Membership(s) (9)：

American Society for Biochemistry and Molecular Biology , 日本細菌学会 , 日本蛋白質科学会 , 日本生物物理学会 , 日本生化学会 , 日本結晶学会 , 日本ビタミン学会 , 毒素シンポジウム , 日本分子生物学会

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