Kagawa Wataru

カガワワタル | Kagawa Wataru

Affiliation and department：
Job title：教授
Homepage URL (1)： https://kenkyu.hino.meisei-u.ac.jp/kagawalab

Research field (3)： Functional biochemistry , Molecular biology , Structural biochemistry

Research keywords (6)： nucleosome , chromatin , DNA repair , homologous recombination , X-ray crystallography , protein-nucleic acid complexes

Research theme for competitive and other funds (17)：

2023 - 2028 クロマチンにおけるDNA修復機構の構造基盤の解明
2023 - 2027 DNA修復特性を用いたがん治療耐性に対する制御機構の解明
2022 - 2025 Roles of liquid-liquid phase separation in DNA double-strand break repair
2020 - 2023 クロマチン上で起こる転写と共役した二重鎖切断修復の分子機構の解明
2019 - 2022 Mechanistic studies of double-strand break repair at repeated sequences in the genome

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Papers (71)：

Takeshi Yasuda, Nakako Nakajima, Tomoo Ogi, Tomoko Yanaka, Izumi Tanaka, Takaya Gotoh, Wataru Kagawa, Kaoru Sugasawa, Katsushi Tajima. Heavy water inhibits DNA double-strand break repairs and disturbs cellular transcription, presumably via quantum-level mechanisms of kinetic isotope effects on hydrolytic enzyme reactions. PLOS ONE. 2024
Takeshi Yasuda, Nakako Nakajima, Tomoko Yanaka, Takaya Gotoh, Wataru Kagawa, Kaoru Sugasawa, Katsushi Tajima. Cell viability is dominated by quantum effects. 2023
Ken Osumi, Tomoya Kujirai, Haruhiko Ehara, Mitsuo Ogasawara, Chiaki Kinoshita, Mika Saotome, Wataru Kagawa, Shun-ichi Sekine, Yoshimasa Takizawa, Hitoshi Kurumizaka. Structural basis of damaged nucleotide recognition by transcribing RNA polymerase II in the nucleosome. Journal of Molecular Biology. 2023. 168130-168130
Ryohei Tsuchiya, Mika Saotome, Chiaki Kinoshita, Kazuki Kamoi, Wataru Kagawa. Biochemical characterization of the RNA-binding and RNA-DNA strand exchange activities of the human RAD52 protein. The Journal of Biochemistry. 2023
Chiaki Kinoshita, Yoshimasa Takizawa, Mika Saotome, Shun Ogino, Hitoshi Kurumizaka, Wataru Kagawa. The cryo-EM structure of full-length RAD52 protein contains an undecameric ring. FEBS Open Bio. 2023. 13. 3. 408-418

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MISC (19)：

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Lectures and oral presentations (90)：

C-terminal Tail of Histone H2AX Reduces Intra-nucleosome Array Interaction
(International Symposium on the Physicochemical Field for Genetic Activities 2011)
The Crystal Structure of Centromere Specific Nucleosome
(International Symposium on the Physicochemical Field for Genetic Activities 2011)
Roles of the N-terminal and C-terminal domains of the Rad52 protein in homologous recombinational repair
(International Symposium on the Physicochemical Field for Genetic Activities 2011)
セントロメア特異的なCENP-Aヌクレオソームの生化学的解析
(第27回染色体ワークショップ 2010)
相同DNA組換えにおける2種の相同DNA対合蛋白質の役割分担
(第27回染色体ワークショップ 2010)

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Education (2)：

1998 - 2003 The University of Tokyo Graduate School of Science Dept. of Biochemistry and Biophysics
- 1997 Wayne State University College of Liberal Arts and Sciences

Professional career (1)：

Work history (7)：

2019/04 - 現在 Meisei University School of Science and Engineering Professor
2012/04 - 2019/03 Meisei University School of Science and Engineering Associate Professor
2010/04 - 2012/03 Waseda University Faculty of Science and Engineering Assistant Professor
2009/04 - 2010/03 Waseda University Faculty of Science and Engineering Research Scientist
2007/04 - 2009/03 RIKEN Systems and Structural Biology Center Research Scientist

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Association Membership(s) (3)：

THE JAPANESE BIOCHEMICAL SOCIETY , PROTEIN SCIENCE SOCIETY OF JAPAN , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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