Rchr
J-GLOBAL ID：200901008919498977
Update date: Jan. 30, 2024
Aiba Tetsuya
アイバ テツヤ | Aiba Tetsuya
Affiliation and department：
Job title：
Associate Professor
Research field (3)：
Pharmaceuticals - chemistry and drug development
, Pharmacology
, Clinical pharmacy
Research keywords (8)：
速度論
, 投与設計
, 薬物代謝
, バイオアベイラビリティ
, 薬物動態
, 消化管吸収
, Bioavailability
, Clinical Pharmacokinetics
Research theme for competitive and other funds (13)：
- 2019 - 2023 Dosage individualization of antianxiety and sedative medication based on modified synaptic function of cerebral GABAergic neurons with peripheral organs failure
- 2019 - 2022 Elucidation of liver mitochondrial failure and autoinflammation with RNA-epigenetics caused by nutrient stress
- 2015 - 2019 Mechanism underlying potentiated pharmacological effects of sedatives with renal failure
- 2012 - 2015 Evaluation of focal availabilities of drugs by monitoring of dynamic diffusion and clearance processes of unbound drug concentrations
- 2012 - 2015 Dose optimization of the central nervous system acting compound considering its altered pharmacokinetics and pharmacodynamics in patients with acute renal failure
- 2009 - 2011 Application of microdialysis techniques to evaluation system for local pharmacokinetics of topically delivered drugs guaranteeing regionally confined drug action
- 2009 - 2011 Understanding mechanisms underlying an increased sensitivity of central nervous system to therapeutic compounds with decreased renal function for dose optimization and individualizing treatment
- 2007 - 2008 Evaluation system for local pharmacokinetics of topically delivered drugs guaranteeing regionally confined drug action
- 2006 - 2007 Mechanisms responsible for interindividual variability of bioavailability of therapeutic compounds in patients with acute renal failure and related homeostasis perturbation
- 2005 - 2006 Mechanism of the pharmacokinetic variability and race difference of β-blockers
- 2003 - 2004 Mechanisms of The Increased Bioavailability of Drugs During Renal Failure
- 2001 - 2002 Interplay between in tasting and liver for the first-pass metabolism of orally administered drugs
- 1999 - 2000 Analysis of barrier function of intestinal drug-metabolizing enzymes and transporters
Show all
Papers (88)：
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Keiichiro Suzuki, Kazuya Matsumoto, Misa Takenaka, Tetsuya Aiba. Altered Pharmacological Efficacy of Phenobarbital with the Treatment of 7,8-Dihydroxyflavone, an Agonist of Tropomyosin Receptor Kinase B, in Rats. Biological and Pharmaceutical Bulletin. 2023. 46. 1. 86-94
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Kojina M, Suzuki K, Nishiwaki A, Aiba T. Acute peripheral inflammation increases plasma concentration of hypoglycemic agent nateglinide with decreased hepatic drug-metabolizing activity in rats. Biological and Pharmaceutical Bulletin. 2021. 44. 1. 96-102
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Doi M, Kajikawa N, Aiba T. Effects of dexamethasone to reverse decreased hepatic midazolam metabolism in rats with acute renal failure. Xenobiotica. 2020. 50. 5. 506-514
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Atsuyoshi Okada, Keiichiro Suzuki, Keisuke Hara, Moeko Kojina, Tetsuya Aiba. In Vivo Study on Mechanism Underlying Increased Pharmacological Effects of Phenobarbital in Rats with Glycerol-Induced Acute Renal Failure. Biological and Pharmaceutical Bulletin. 2019. 42. 3. 501-506
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Yuki Hori, Yasumasa Shimizu, Tetsuya Aiba. Altered hepatic drug-metabolizing activity in rats suffering from hypoxemia with experimentally induced acute lung impairment. Xenobiotica. 2018. 48. 6. 576-583
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MISC (12)：
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森 泰裕, 小川 敦, 高橋 舞, 森山 総一郎, 上原 麻未, 中山 祥江, 合葉 哲也, 黒崎 勇二. P-0931 L-HPC含水ゲルシートの湿潤療法用被覆型外用基剤としての製剤的特性(一般演題 ポスター発表,褥そう対策,Enjoy Pharmacists' Lifestyles). 日本医療薬学会年会講演要旨集. 2011. 21. 337-337
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高畑 友紀子, 堀内 瑞樹, 森山 総一郎, 合葉 哲也, 黒崎 勇二. P-0839 腹腔内-全身循環血間の薬物移行動態に及ぼす脂肪乳剤の影響 : 腹腔内投与時の移行動態(一般演題 ポスター発表,薬物病態(基礎),Enjoy Pharmacists' Lifestyles). 日本医療薬学会年会講演要旨集. 2011. 21. 321-321
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福永航也, 合葉哲也, 齋藤弥代子, 武藤眞, 渡辺直之, 内田恵子, 奥野征一, 小林孝之, 折戸謙介. てんかん症例犬のゾニサミド血中濃度に影響を与える体重,犬種および併用薬の有無に関する検討. 日本獣医学会学術集会講演要旨集. 2011. 152nd
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舛田 あゆみ, 後藤 祐子, 合葉 哲也, 黒崎 勇二. P1-250 キトサンによるアシクロビルの消化管吸収促進に関する検討(一般演題 ポスター発表,薬物動態・TDM・投与設計,臨床から学び臨床へと還元する医療薬学). 日本医療薬学会年会講演要旨集. 2010. 20. 328-328
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合葉 哲也, 田中 亮裕, 大塚 尚, 川崎 博己, 黒崎 勇二, 井上 智喜, 末丸 克矢, 荒木 博陽. P2-271 アルベカシンの血中濃度モニタリングにおける腎機能マーカーシスタチンCの有用性評価(一般演題 ポスター発表,薬物動態(臨床、TDM),医療薬学の創る未来 科学と臨床の融合). 日本医療薬学会年会講演要旨集. 2009. 19. 432-432
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Books (1)：
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個別化医療を目指した臨床薬物動態学1-基礎編(共著)
廣川書店 2016 ISBN:9784567484909
Lectures and oral presentations (161)：
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ラット肝薬物代謝酵素CYP3A2のユビキチン分解に関する基礎的検討
(日本薬学会第143年会 2023)
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神経栄養因子受容体TrkBを介する抗てんかん薬レベチラセタムのin vivo作用増強
(日本薬学会 第143年会 2023)
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Altered hypoglycemic property of nateglinide in rats under acute inflammatory conditions
(2022)
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A pharmacodynamic factor potentiating the cerebral pharmacological activity of phenobarbital in rats
(2022)
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炎症病態に伴う血糖降下薬ナテグリニドの薬効変動の解析
(日本薬学会 第140年会 2020)
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Education (4)：
- - 1991 Kyoto University
- - 1991 Kyoto University Graduate School, Division of Pharmaceutical Sciences
- - 1987 Kyoto University Faculty of Pharmaceutical Sciences
- - 1987 Kyoto University Faculty of Pharmaceutical Science
Professional career (1)：
Work history (2)：
- 2005 - - 岡山大学医歯薬学総合研究科 准教授
- 2005 - - Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
Association Membership(s) (3)：
米国薬学会(American Association of Pramoceutical Scientists)
, 日本薬物動態学会
, 日本薬学会
