Nishikata Ichiro

ニシカタイチロウ | Nishikata Ichiro

Research field (3)： Hematology and oncology , Immunology , Applied molecular and cellular biology

Research keywords (4)： Prostate Cancer , Exosome , Enzyme Immunoassay , ATLL

Research theme for competitive and other funds (14)：

2013 - 2016 Analysis of ATL leukemogenesis through breakage of defense mechanism of HTLV-1 infection
2013 - 2015 Pathologic analysis of Adult T-cell leukemia/lymphoma (ATL) usung TSLC1/CAV1, novel secreting proteins related to exosome
2009 - 2011 Molecular analysis of leukemogenesis of adult-T cell leukemia by genomic abnormalities
2009 - 2009 超高感度マルチ発光 ELISA 法応用した翻訳後修飾 SUMO 化多重同時評価システムの構築
2008 - 2009 Evi1遺伝子群による細胞接着を介した白血病幹細胞維持機構の解明

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Papers (25)：

Nakahata S, Syahrul C, Nakatake A, Sakamoto K, Yoshihama M, Nishikata I, Ukai Y, Matsuura T, Kameda T, Shide K, et al. Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma. Haematologica. 2020. 105. 2. 532-542
Sarkar B, Nishikata I, co, Nakahata S, Ichikawa T, Shiraga T, Saha H. R, Fujii M, Tanaka Y, Shimoda K, et al. Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB. Scientific Reports. 2019. 9. 1. Article number:3491(1)-Article number:3491(14)
サルカル・ビードン, 西片一郎, 中畑新吾, 市川朝永, 藤井雅寛, 伊波英克, 森下和広. 成人T細胞白血病においてp47発現低下によるNF-κB活性化はCADM1の高発現を誘導する. 日本癌学会総会記事. 2017. 76回. P-1068
Sugie S, Mukai S, Tsukino H, Toda Y, Yamauchi T, Nishikata I, Kuroda Y, Morishita K, Kamoto T. Increased plasma caveolin-1 levels are associated with progression of prostate cancer among Japanese men. Anticancer Research. 2013. 33. 5. 1893-1898
Nishikata I, Nakahata S, Saito Y, Kaneda K, Ichihara E, Yamakawa N, Morishita K. Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation. Oncogene. 2011. 30. 40. 4194-4207

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MISC (7)：

白血病化に関係する新規zinc finger protein MEL1の単離と機能解析. 第23回日本分子生物学会年会講演要旨集. 2000. 341
Isolation and characterization of a novel zinc finger protein, MEL1, which is associated with leukemogenesis. 2000. 341
K Hashinaka, Nishikata, I, S Hashida, A Adachi, S Oka, E Ishikawa. Preparations of recombinant HIV-1 p66 antigen to improve the specificity of immune complex transfer enzyme immunoassay of antibody IgG to HIV-1 reverse transcriptase. JOURNAL OF CLINICAL LABORATORY ANALYSIS. 2000. 14. 4. 169-179
石川栄治, 西片一朗, 橋田誠一. 体液中の微量のニコチン及びコチニンの定量法開発に関する研究-酵素免疫測定法による検討-. 日本喫煙科学財団研究年報. 1994. 836-843
Development of methods for the detection of nicotine and cotinine at low concentration in body fluids -application of enzyme immunoassay-. Smoking Research Foundation Annual Reserach Report. 1994. 866

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Lectures and oral presentations (18)：

Down-regulation of p47 induces high expression of CADM1 via the NF -kB pathway in adult T-cell leukemia/lymphoma.
(2019)
新規腫瘍マーカー候補としての前立腺がん特異的エクソソームの解析
(第57回日本臨床化学会年次学術集会 2017)
カベオリン1(CAV1)含有エクソソームは前立腺がんの新規腫瘍マーカー候補である
(第63回日本臨床検査医学会学術集会 2016)
Promoteosomal degradation of p47 by HTLV-1 Tax with prpmoter methylation enhannced CADM1 expression in ATL cells
(The 74th Annual Meeting of the Japanese Cancer Association 2015)
血中CADM1/TSLC1測定によるATL診断法の開発
(第1回HTLV-1学会総会 2014)

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Professional career (1)：

Work history (4)：

2015/04 - 現在 Kyushu University of Health and Welfare School of Medical Life Sciences Department of Medical Life Sciences
2007/04 - 2015/03 University of Miyazaki Faculty of Medicine School of Medicine
2003/10 - 2007/03 University of Miyazaki Faculty of Medicine School of Medicine
1993/04 - 2003/09 宮崎医科大学生化学第一講座助手

Association Membership(s) (5)：

日本臨床化学会 , 日本分子生物学会 , 日本生化学会 , 日本血液学会 , 日本癌学会

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