Shimoyama Yu

Research field (2)： Immunology , Bacteriology

Research keywords (5)：プロテアーゼ , 細菌学 , 免疫学 , Cell-proliferation , Inflammation

Research theme for competitive and other funds (22)：

2022 - 2026 癌関連口腔レンサ球菌由来抗原の感染発癌における病原性の解明
2022 - 2025 がん微小環境における腫瘍免疫破綻因子としての口腔細菌ジペプチダーゼ
2022 - 2025 在宅看護でのオーラルリテラシーを向上させる新たな口腔衛生教育ツール開発
2021 - 2024 口腔マイコプラズマのヒト口腔粘膜上皮ゲノム変異因子としての可能性
2020 - 2024 低体重出生に関わる苦味受容体を介した歯周病原細菌の影響

2020 - 2024 間葉系幹細胞由来ペプチドを利用した炎症抑制と組織再生の両立を実現する治療法の確立

2019 - 2022 Identification of cysteine peptidases that assure complete dipeptide production in periodontopathic bacteria

2019 - 2022 Novel modulating mechanisms of homeostasis by oral bacterial exopeptidases

2018 - 2021 The growth mechanism of Porphyromonas gingivalis, a member of periodontpathic bacteria, via incorporation of dipeptides.

2017 - 2020 The involvement of aberrant AID expression in human gingival epithelial cells with Streptococcus anginosus antigen on the mechanisms of oral cancer.

2016 - 2020 Establishment of cell therapy for periodontitis accompanied by tissue regeneration utilizing anti-inflammatory peptide secreted by mesenchymal stem cells

2016 - 2019 Relations of periodontal diseases to systemic diseases and involvement of degradation of bioactive peptides by oral bacterial peptidases

2015 - 2018 Infection control with secretory leukocyte protease inhibitor (SLPI) via the inhibitory effect on the invasion of periodontopathic bacteria across gingival epithelial barrier

2015 - 2018 Exopeptidases from periodontopathic bacteria as risk factors of type-2 diabetes mellitus

2014 - 2017 Preoperative Oral Care Reduces The Bacterial Adhesion To Endotracheal Tubes

2013 - 2016 The analysis of induction of aberrant AID expression and mutagenesis in TP53 in human gingival epithelial cells with carcinogenic bacteria

2012 - 2015 Infection control with SLPI via the inhibitory effect on the proteases of Porphyromonas gingivalis

2010 - 2012 The identification of cell surface antigen of oral streptococcus for development of vaccine for oral cancer

2010 - 2012 Study on the Glu-specific protease superfamily mediating dissociation of cell-cell adhesion

2009 - 2011 Inhibition of P. gingivalis infection by the SLPI from gingival epithelial cells

2007 - 2008 Identification of phosphorylated proteins in murine B cells in relation to the LPS-induced proliferative response

2003 - 2006 Porphyromonas Gingiralis LPS induced Bcell activation

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Papers (47)：

Mizuki Sekiya, Kazuya Ikeda, Ayaka Yonai, Taichi Ishikawa, Yu Shimoyama, Yoshitoyo Kodama, Minoru Sasaki, Mayumi Nakanishi-Matsui. F-type proton-pumping ATPase mediates acid tolerance in Streptococcus mutans. Journal of applied microbiology. 2023. 134. 4
Shu SATO, Minoru SASAKI, Yu SHIMOYAMA, Kenichi SATO, Taichi ISHIKAWA. Extracellular Tryptophanyl-tRNA Synthetase from Alveolar Epithelial Cells Infected with Staphylococcus aureu s and its Inflammatory Response. Dental Journal of Iwate Medical University. 2023. 48. 1. 1-10
Manami Nakasato-Suzuki, Yu Shimoyama, Yuko Ohara-Nemoto, Daisuke Sasaki, Takayuki K. Nemoto, Takashi Yaegashi. Exacerbation mechanism of type 2 diabetes mellitus by periodontopathic bacterial dipeptidyl-peptidases (DPPs). Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology). 2023. 65. 1. 1-8
Yu Shimoyama, Daisuke Sasaki, Yuko Ohara-Nemoto, Takayuki K Nemoto, Manami Nakasato, Minoru Sasaki, Taichi Ishikawa. Immunoelectron Microscopic Analysis of Dipeptidyl-Peptidases and Dipeptide Transporter Involved in Nutrient Acquisition in Porphyromonas gingivalis. Current microbiology. 2023. 80. 4. 106-106
Yuko Ohara Nemoto, Yu Shimoyama, Toshio Ono, Mohammad Tanvir Sarwar, Manami Nakasato, Minoru Sasaki, Takayuki K. Nemoto. Expanded substrate specificity supported by P1’ and P2’ residues enables bacterial dipeptidyl-peptidase 7 to degrade bioactive peptides. Journal of Biological Chemistry. 2022. 101585-101585

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MISC (25)：

石河太知, 下山佑, 古玉芳豊, 小笠原正人, 佐々木実. ヒト臍帯静脈内皮細胞におけるTAS2R発現に及ぼす細菌感染の影響(The effect of bacterial infection on the expression of TAS2R in human umbilical vein endothelial cells). 日本細菌学雑誌. 2019. 74. 1. 141-141
關谷瑞樹, 泉澤信太郎, 櫛桁安生, 芳賀雅人, 下山佑, 石河太知, 佐々木実, 佐々木由香, 岩本(木原)昌子, 中西(松井)真弓. プロトン輸送F-ATPase阻害剤によるStreptococcus mutansの耐酸性の低下. 日本生化学会大会(Web). 2018. 91st. ROMBUNNO.2P-145 (WEB ONLY)-145]
中里茉那美, 下山佑, 根本優子, 佐々木大輔, 根本孝幸, 佐々木実, 八重柏隆. 2型糖尿病のリスクファクターとしての歯周病原細菌DPP4. 岩手医科大学歯学雑誌. 2018. 43. 1. 48-60
關谷瑞樹, 泉澤信太郎, 櫛桁安生, 芳賀雅人, 下山佑, 佐々木実, 木村重信, 佐々木由香, 岩本(木原)昌子, 中西(松井)真弓. Streptococcus mutansの耐酸性におけるF-ATPaseの重要性. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.2P-0249 (WEB ONLY)-0249]
村上智彦, 下山佑, 野村太郎, 石河太知, 近藤尚知, 佐々木実. 義歯安定剤によるCandida albicans病原性の変化. Journal of Oral Biosciences Supplement. 2017. 2017. 499-499

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Professional career (1)：

歯学博士 (岩手医科大学)

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