Rchr
J-GLOBAL ID：200901009532752634
Update date: Oct. 31, 2024
Kono Hidetoshi
コウノ ヒデトシ | Kono Hidetoshi
Affiliation and department：
Job title：
Group Leader
Research field (5)：
Biophysics
, Systems genomics
, Genomics
, Molecular biology
, Biological, health, and medical informatics
Research keywords (1)：
protein-DNA; nucleosome; protein design; DNA-binding protein; molecular modeling
Research theme for competitive and other funds (19)：
- 2018 - 2023 ヌクレオソーム高次構造とダイナミクスの解析によるクロマチン潜在能の解明
- 2015 - 2018 International research network for chromatin structure, dynamics, and function
- 2013 - 2018 Chromatin dynamics analysis using computer simulation
- 2013 - 2018 Chromatin structure, dynamics, and function
- 2014 - 2017 Improvement of sequence specificity of DNA-binding protein using computational and experimental approaches
- 2012 - 2017 Elucidation of information-processing mechanisms during transcription cycle using computational and information sciences
- 2011 - 2013 ヌクレオソーム構造の自由エネルギープロファイル解析
- 2009 - 2010 シミュレーション計算によるヌクレオソーム構造形成の自由エネルギー地形解析
- 2009 - 2010 DNA配列に特異的に結合するタンパク質分子設計
- 2008 - 2010 Regulation of Gene Transcription Inferred From Transcription Factor Binding and Nucleosome Positioning
- 2007 - 2008 中性子散乱実験と分子動力学計算による蛋白質-DNA認識機構における水の挙動解析
- 2004 - 2004 転写因子のターゲット部位予側にもとづく遺伝子の機能及び相互作用推定
- 2003 - 2004 蛋白質の機能部位推定及びSNPによる機能変化の予側
- 2003 - 2003 転写因子のターゲット部位予側からのゲノム機能推定
- 1998 - 1998 DNA結合蛋白質の機能性cavityと立体構造安定性
- hydration around DNA/protein
- de novo design of proteins
- DNA-binding protein
- protein-DNA recognition
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Papers (151)：
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Masahiko Taguchi, Shun Sakuraba, Justin Chan, Hidetoshi Kono. Unveiling the Photoactivation Mechanism of BLUF Photoreceptor Protein through Hybrid Quantum Mechanics/Molecular Mechanics Free-Energy Calculation. ACS Physical Chemistry Au. 2024
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Akiko Fujimura, Hisashi Ishida, Tamiko Nozaki, Shuhei Terada, Yuto Azumaya, Tadashi Ishiguro, Yugo R Kamimura, Tomoya Kujirai, Hitoshi Kurumizaka, Hidetoshi Kono, et al. Designer Adaptor Proteins for Functional Conversion of Peptides to Small-Molecule Ligands toward In-Cell Catalytic Protein Modification. ACS central science. 2023. 9. 11. 2115-2128
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Hisashi Ishida, Atsushi Matsumoto, Hiroki Tanaka, Aya Okuda, Ken Morishima, Paul A Wade, Hitoshi Kurumizaka, Masaaki Sugiyama, Hidetoshi Kono. Structural and Dynamical Changes of Nucleosome upon GATA3 Binding. Journal of molecular biology. 2023. 168308-168308
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Junichi Higo, Kota Kasahara, Gert-Jan Bekker, Benson Ma, Shun Sakuraba, Shinji Iida, Narutoshi Kamiya, Ikuo Fukuda, Hidetoshi Kono, Yoshifumi Fukunishi, et al. Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR and a middle sized flexible molecule. Scientific Reports. 2022. 12. 1
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Justin Chan, Amarjeet Kumar, Hidetoshi Kono. RNAPII driven post-translational modifications of nucleosomal histones. Trends in Genetics. 2022
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MISC (31)：
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柚木康弘, 松本淳, 守島健, MARTEL Anne, PORCAR Lionel, 佐藤信浩, 與語理那, 與語理那, 與語理那, 富永大輝, et al. The Advantage of Small-angle Neutron Scattering Revealed through Analyzing the Overall Structure of a Fully Assembled Complex in Circadian Clock. 波紋. 2022. 32. 4
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Hidetoshi Kono, Hisashi Ishida. Nucleosome unwrapping and unstacking. Current Opinion in Structural Biology. 2020. 64. 119-125
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藤巻秀, 五十嵐龍治, 高草木洋一, 安達基泰, 横谷明徳, 玉田太郎, 河野秀俊, 鹿園直哉, 今岡達彦, 赤松憲, et al. 最先端の研究開発 量子科学技術研究開発機構 第4回「量子生命科学」の発進. ΑΤΟΜΟΣ. 2019. 61. 6. 477-481
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Zhenhai Li, Jinzen Ikebe, Shun Sakuraba, Hidetoshi Kono. Distinct Roles of H3 and H2A Tails in Linker DNA Dynamics. BIOPHYSICAL JOURNAL. 2017. 112. 3. 373A-373A
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Hisashi Ishida, Hidetoshi Kono. The Free-Energy Landscape of the di-Nucleosome: A Critical Role of the H4 Tails for the Nucleosome-Nucleosome Conformation. BIOPHYSICAL JOURNAL. 2017. 112. 3. 216A-216A
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Awards (2)：
- 2013/09 - 日本生物物理学会 第2回BIOPHYSICS論文賞
- 2002 - Oxford Univ. Press Bioinformatics Prise
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