Rchr
J-GLOBAL ID：200901009705949242   Update date: Aug. 26, 2024

UNNO Masaki

ウンノ マサキ | UNNO Masaki
Affiliation and department：
Ibaraki University Graduate School of Science and Engineering (Engineering) Department of Materials Science and Engineering

About Ibaraki University Graduate School of Science and Engineering (Engineering) Department of Materials Science and Engineering


Job title： Professor
Homepage URL  (1)： http://unno19.quantum.ibaraki.ac.jp/mysite1/index.html
Research field  (2)： Biochemistry ,  Structural biochemistry
Research keywords  (1)： Protein, Structure, Function, X-ray crystallography, Atomic level, Reaction mechanism, Drug design, Intermediate
Research theme for competitive and other funds  (28)：
  • 2023 - 2025 シアノバクテリア光センサーのプロトン化状態の解明に資する構造基盤
  • 2022 - 2023 生体必須の金属補因子「鉄硫黄クラスター」の生合成機序と無細胞構築系の確立
  • 2021 - 2022 水素原子が関与するタンパク質の機能発現機構の解明
  • 2021 - 2022 DNA 損傷修復に関わるタンパク質の立体構造と薬剤設計
  • 2021 - 2022 種々のタンパク質の立体構造とその機能の相関に関する精密解析
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Papers (70)：
  • 海野昌喜, 城塚達也, 杉島正一, 和田啓, 萩原義徳, 矢野直峰,Andreas Ostermann, 日下勝弘. ビリン還元酵素PcyAの二つの変異体の吸収スペクトルおよび反応の変化とプロトン化状態との相関. 波紋. 2023. 33. 4. 151-156
  • Furuya, T., *Nakane, D., Kitanishi, K., Katsuumi, N., Tsaturyan, A., et al. A novel hybrid protein composed of superoxide-dismutase-active Cu(II) complex and lysozyme. Scientific Reports. 2023. 13. 6892
  • Tatsuya Joutsuka, Ryota Nanasawa, Keisuke Igarashi, Kazuki Horie, Masakazu Sugishima, Yoshinori Hagiwara, Kei Wada, Keiichi Fukuyama, Naomine Yano, Seiji Mori, et al. Neutron crystallography and quantum chemical analysis of bilin reductase PcyA mutants reveal substrate and catalytic residue protonation states. J. Biol. Chem. 2022. 299. 1. 102763-102763
  • Mizuki Sawata, Hiroki Shima, Kazutaka Murayama, Toshitaka Matsui, Kazuhiko Igarashi, Kazumasa Funabashi, Kenji Ite, Kenji Kizawa, Hidenari Takahara, and Masaki Unno. Autocitrullination and Changes in the Activity of Peptidylarginine Deiminase 3 Induced by High Ca2+ Concentrations. ACS Omega. 2022. 7. 32. 28378-28387
  • Kitanishi, K.*, Shimonaka, M., and Unno, M. Characterization of a Cobalt-Substituted Globin-Coupled Oxygen Sensor Histidine Kinase from Anaeromyxobacter sp. Fw109-5: Insights into Catalytic Regulation by Its Heme Coordination Structure. ACS Omega. 2021. 6. 50. 34912-34919
ｍore...
MISC (71)：
  • Yuki FUJITA, Masakazu SUGISHIMA, Masaki UNNO. Neutron structural studies to elucidate the reaction mechanism of phytochromobilin synthase, HY2. 2024. 41
  • Masataka KOGA, Nozomi MINOWA, Saki KOMURO, Masayuki MORIKAWA, Yoshikazu HATTORI, Yoshiyuki TANAKA, Masaki UNNO. Trapping Reaction Intermediates of the DNA Oxidative Damage Repair Enzyme, hOGG1 and Their Structures. 2024. 41
  • M. Unno, T. Joutsuka, M. Sugishima, K. Wada, Y. Hagiwara, N. Yano, K. Kusaka, A. Ostermann. Neutron crystallography combined with QM/MM calculations of bilin reductase PcyA mutants reveal substrate and catalytic residue protonation states. Joint Annual Report 2023 of the MLZ and FRM II. 2024
  • Unno, M. Modes of PADing. Nature Chemical Biology. 2024
  • 海野昌喜. 酵素の動的立体構造解析を基盤とした酵素反応機構の解明. KEK放射光 Conceptional Design Reports ver. 1.1. 2017. 1. 1. 109-111
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Books (8)：
  • Structures and Functions of Peptidylarginine Deiminases,(Protein Deimination in Human Health and Disease 2)
    Springer 2017 ISBN:9783319582443
  • A Guide to Synchrotron Radiation Science
    Narosa 2016 ISBN:9788184873733
  • 日本の結晶学(II)ーその輝かしい発展ー
    日本結晶学会 2014 ISBN:9784990386115
  • Protein Deimination in Human Health and Disease
    Springer 2014 ISBN:9781461483175
  • Integrating Approach to Photofunctional Hybrid Materials for Energy and the Environment
    Nova Publishers 2013 ISBN:9781624176388
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Lectures and oral presentations  (264)：
  • PAD3 autocitrullination and the structure
    (EMBO Workshop Mechanisms of Citrullination Regulation in Health and Disease 2024)
  • DNA 修復酵素 hOGG1 の変異体を用いた酵素反応中間体の構造決定とその反応機構
    (第50回 生体分子科学討論会 2024)
  • Cotrol factor of the redox potential of [4Fe-4S] ferredoxin based on its structure and the density
    (2024)
  • hOGG1新規活性型変異体を用いた塩基修復反応メカニズムの解析
    (日本薬学会第144年会 2024)
  • フィトクロモビリン合成酵素 HY2の反応機構解明に向けた中性子構造生物学的研究
    (2023年度量子ビームサイエンスフェスタ 2024)
ｍore...
Education (2)：
  • 1998 - 2002 Osaka University Graduate School, Division of Natural Science Macromolecular Science
  • 1992 - 1996 Osaka University Faculty of Science Macromolecules
Professional career (1)：
  • Ph. D. (Osaka University)
Work history (5)：
  • 2013/04 - Professor, Graduate School of Science and Engineering, Ibarali University
  • 2009/05 - 2013/03 Associate Professor of Frontier Research Center for Applied Atomic Sciences, Ibaraki University
  • 2007/04 - 2009/04 Assistant Professor of Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
  • 2002/04 - 2007/03 Research Associate of Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
  • 1998/04 - 2001/03 JSPS Research Fellowship (DC1)
Committee career (13)：
  • 2023/11 - 2025/09 国立研究開発法人日本原子力研究開発機構,大学共同利用機関法人高エネルギー加速器研究機構 中性子課題審査分科会委員
  • 2023/10 - 2025/09 一般財団法人総合科学研究機構 利用研究課題審査委員会分科会委員
  • 2023/04 - 2025/03 日本結晶学会 評議員
  • 2022/04 - 2024/03 日本結晶学会 役員(庶務幹事)
  • 2021/04 - 2024/03 PF-UA PF-UA 機構外運営委員
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Awards (2)：
  • 2007/11 - 籏野奨学基金 多元研究奨励賞
  • 2005/11 - 日本生物物理学会 日本生物物理学会若手奨励賞
Association Membership(s) (4)：
The Biophysical Society of Japan ,  The Japanese Biochemical Society ,  Protein Science Society of Japan ,  The Crystallography Society of Japan
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