Research field (7)：
Neuroanatomy and physiology
, Nervous system function
, Neuroscience - general
, Neurosurgery
, Physiology
, Molecular biology
, Functional biochemistry
Research theme for competitive and other funds (35)：
2022 - 2025 A novel therapeutic strategy for ischemic stroke based on understanding how subsequently induced Npas4 expression potentiates protecting neurons from death
2019 - 2023 A novel therapeutic strategy for ischemic stroke based on reshaping neuronal circuits in an activity-dependent manner
2019 - 2022 A novel therapeutic strategy for ischemic stroke based on the activity-dependent transcription factor Npas4
2017 - 2019 Molecular mechanisms underlying functional recovery of cerebral neural circuits impaired by ischemic stroke
2016 - 2019 Molecular mechanisms underlying activity-dependent reorganization of neural circuits in the olfactory bulb on the basis of adult neurogenesis
2015 - 2018 A novel therapeutic strategy for ischemic stroke based on understanding adult neurogenesis
2015 - 2017 成体神経新生を利用した障害脳神経回路の機能的再建
2013 - 2016 Sensory-experience dependent development of olfactory bulb interneurons
2013 - 2016 Molecular mechanisms that regulate the sensory experience-dependent development of dendritic spines in newborn olfactory bulb interneurons
2012 - 2015 Role of complement regulatory factors in synapse pruning and in schizophrenia pathogeny
2012 - 2014 A novel molecular mechanism underlying the sense of oily odorants by olfaction
2011 - 2012 Activity dependent development of newborn olfactory bulb interneurons
2009 - 2011 Multilateral analysis of Neuregulin-1 function in schizophrenia patients.
2009 - 2010 マウス嗅覚系におけるCO2センサーの新規動作機構の解明
2008 - 2010 Generation, differentiation and integration of neural stem cells into neural circuits in the adult olfactory system
2005 - 2006 Molecular basis of odorant receptor genes expression and axonal projection of olfactory sensory neurons using zebrafish
2005 - 2005 嗅覚受容体多重遺伝子の発現制御機構からみた脊椎動物の進化
2004 - 2005 A Molecular Basis on Generation and Regenaration of the Olfactory Sensory Map
2004 - 2004 嗅球における匂い地図形成の分子基盤
2003 - 2004 嗅覚系における神経回路の形成と再生の分子機構
2003 - 2003 嗅球におけるトポグラフィックな匂い地図形成の分子基盤
2002 - 2003 Transgenic approach to clarify regulatory mechanisms of odorant receptor gene expression
2002 - 2002 嗅球に対する嗅神経細胞のトポグラフィックな軸索投射の分子機構
2001 - 2002 嗅覚系における神経回路の形成と再生の分子基盤
2001 - 2001 嗅覚受容体の発現に依存した嗅覚神経回路形成の分子機構
2000 - 2001 Transgenic approach to clarify regulatory mechanisms of odorant receptor gene expression
2000 - 2000 嗅覚系における神経回路形成の分子的基盤
2000 - 2000 嗅覚系における神経回路網形成の分子基盤
1999 - 2000 嗅覚系における神経回路形成の分子機構-嗅神経細胞の標的特異的な軸索投射-
1999 - 1999 嗅覚受容体多重遺伝子系の発現制御
1995 - 1999 Regulation and Molecular Mechanisms of Antigen Receptor Gene Rearrangements
1994 - 1994 匂いの受容体遺伝子の発現調節の機構・遺伝子再構成の可能性...
1994 - 1994 脊椎動物の嗅覚器官における神経回路の形成と再生の分子機構
1987 - 1988 Molecular assembly mechanism on pseudocrystalline surface layer of B. brevis 47
1986 - 1987 Efficient production of useful proteins by proteinproducing bacterium and its secretion vector
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Papers (47)：
Hiroo Takahashi, Tohru Yamamoto, Akio Tsuboi. Molecular mechanisms underlying activity-dependent ischemic tolerance in the brain. Neuroscience research. 2022
Hiroo Takahashi, Ryo Asahina, Masayuki Fujioka, Takeshi K Matsui, Shigeki Kato, Eiichiro Mori, Hiroyuki Hioki, Tohru Yamamoto, Kazuto Kobayashi, Akio Tsuboi. Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 32
Hiroo Takahashi, Sei-ichi Yoshihara, Yoichi Ogawa, Ryo Asahina, Tatsuro Kitano, Akio Tsuboi. A specific subtype of olfactory bulb interneurons is necessary for odor detection and odor-background segregation. CHEMICAL SENSES. 2016. 41. 9. E148-E148
Takaaki Sato, Reiko Kobayakawa, Ko Kobayakawa, Makoto Emura, Shigeyoshi Itohara, Miwako Kizumi, Hiroshi Hamana, Akio Tsuboi, Junzo Hirono. Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: Evidence for hierarchical odor coding. CHEMICAL SENSES. 2016. 41. 9. E139-E139
Seiichi Yoshihara, Akio Tsuboi. Transcription factor Npas4 regulates the development of dendritic spines in newborn olfactory bulb interneurons depending on sensory experience. Seikagaku. 2016. 88. 2. 220-224
Akio Tsuboi, Hitoshi Sakano. Odorant Receptor Gene Regulation. Handbook of Olfaction and Gustation: Third Edition. 2015. 123-132
Transmembrane protein 5T4 regulates dendrite arborization of olfactory bulb interneurons in an odor-evoked activity-dependent process.
(Neuroscience 2011, Pacifico Yokohama 2011)
Molecular mechanisms underlying formation of the odor map in the mouse brain.
(Neuroscience 2008, Tokyo International Forum 2008)
Professional career (1)：
農学博士 (名古屋大学)
Work history (10)：
2023/04 - 現在 Osaka University Graduate School of Pharmaceutical Sciences Invited Professor
2019/03 - 2023/03 Osaka University Graduate School of Frontier Biosciences
2006 - 2018 Nara Medical University Medical Faculty
1996 - 2006 The University of Tokyo Graduate School of Science
2000 - 2003 科学技術振興事業団・さきがけ研究21 研究員兼任
1993 - 1996 岡崎国立共同研究機構 基礎生物学研究所 助手
1993 - 1994 The University of Tokyo The Institute of Medical Science
1989 - 1993 米国DNAX分子細胞生物学研究所 博士研究員
1982 - 1991 Nagoya University School of Agricultural Sciences
